YWHAB and PDE3B

Number of citations of the paper that reports this interaction (PMID 12453887)
7

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		YWHAB	PDE3B
Gene Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta	phosphodiesterase 3B, cGMP-inhibited
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Transcriptional Repressor Complex Cytoplasmic Vesicle Membrane Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Endoplasmic Reticulum Golgi Apparatus Cytosol Membrane Integral Component Of Membrane Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Protein Complex Binding Histone Deacetylase Binding Phosphoserine Binding Phosphoprotein Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity CGMP-inhibited Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Protein Kinase B Binding Metal Ion Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Protein Targeting Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Negative Regulation Of Protein Dephosphorylation Hippo Signaling Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Innate Immune Response Negative Regulation Of Transcription, DNA-templated Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cytoplasmic Sequestering Of Protein Protein Heterooligomerization Membrane Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Angiogenesis CAMP Catabolic Process Negative Regulation Of Cell Adhesion Blood Coagulation Insulin Receptor Signaling Pathway Negative Regulation Of Angiogenesis Endocrine Pancreas Development Cellular Response To Insulin Stimulus Negative Regulation Of Cell Adhesion Mediated By Integrin Glucose Homeostasis Negative Regulation Of CAMP-mediated Signaling Regulation Of Insulin Secretion Negative Regulation Of Lipid Catabolic Process
Pathways		Signaling by GPCR Signaling by FGFR in disease Activation of BH3-only proteins MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Rap1 signalling Gastrin-CREB signalling pathway via PKC and MAPK SOS-mediated signalling SHC-mediated signalling Signaling by PDGF Regulation of mRNA stability by proteins that bind AU-rich elements DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Signalling to RAS Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Adaptive Immune System Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling Translocation of GLUT4 to the plasma membrane IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation RAF phosphorylates MEK Downstream signaling of activated FGFR Programmed Cell Death NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Intrinsic Pathway for Apoptosis Butyrate Response Factor 1 (BRF1) destabilizes mRNA Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer Tristetraprolin (TTP) destabilizes mRNA NGF signalling via TRKA from the plasma membrane SHC-related events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR ARMS-mediated activation Signaling by Hippo RAF activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	Signaling by GPCR Insulin receptor signalling cascade G alpha (s) signalling events IRS-mediated signalling IRS-related events PDE3B signalling cGMP effects IGF1R signaling cascade IRS-related events triggered by IGF1R GPCR downstream signaling IRS-mediated signalling Platelet homeostasis Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Nitric oxide stimulates guanylate cyclase PKB-mediated events PKB-mediated events PDE3B signalling PI3K Cascade PI3K Cascade Signaling by Insulin receptor
Drugs			(5r)-6-(4-{[2-(3-Iodobenzyl)-3-Oxocyclohex-1-En-1-Yl]Amino}Phenyl)-5-Methyl-4,5-Dihydropyridazin-3(2h)-One Hg9a-9, Nonanoyl-N-Hydroxyethylglucamide 3-ISOBUTYL-1-METHYLXANTHINE
Diseases
GWAS
Protein-Protein Interactions		137 interactors: ABL1 ADAM22 AKAP13 ALS2 APP ATP5A1 BAD BAX BCL2L11 BCR BID BRAF C1QBP CAMK2A CAMK2B CBL CDC25A CDC25B CDC25C CDK11B CDK14 CDKN1B CHAF1A CRTC2 CSNK2A1 DAPK1 DHX15 DYRK1A EDC3 EPB41 EPB41L1 EPB41L3 EXO1 FER FRMD6 GAPVD1 GEM HDAC5 HES1 HIST1H3A HSP90AB1 HSPA1A HSPA1B HSPA5 IGF1R IKBKB ING1 INSR IRS1 IRS2 ITGB1 ITGB4 KCNK15 KCNK3 KCNK9 KIAA0930 KIF1C KIF23 KIF5B KLC1 KRT18 LARP1 LYST MAP3K3 MAPK7 MAPT MARK2 MARK4 MDM4 MICALL1 MINK1 MLLT4 MLXIP MPRIP MST1R OSBPL3 PARD3 PARD6B PDCL2 PDE3B PI4KB PIK3R2 PIK3R4 PRKCD PRKCG PRKCZ PRPF6 PTPN3 RABGEF1 RACGAP1 RADIL RAF1 RAI14 RALGPS2 RASGRF1 RGS3 RGS7 RIN1 RIOK1 RMDN3 RNPS1 RPS6KA1 SAMSN1 SKP2 SLC4A7 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SNCA SNRNP200 SON SRC SRPK2 SRRM2 SRSF10 SRSF3 STK38 STK38L TESK1 TESK2 TH TJP2 TNFAIP3 TPD52L1 TSC1 TSC2 TUBB UBC UCP2 UCP3 WDR77 WEE1 YWHAE YWHAG ZFP36 ZFP36L1	5 interactors: AKT1 ANKRA2 PRKACA YWHAB YWHAQ
Entrez ID		7529	5140
HPRD ID		03184	03626
Ensembl ID		ENSG00000166913	ENSG00000152270
Uniprot IDs		P31946	A7E2E5 B7ZM37 Q13370
PDB IDs		2BQ0 2C23 4DNK	1SO2 1SOJ
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Cell Death Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Cell Communication Regulation Of Apoptotic Process Regulation Of Signal Transduction Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Response To Organic Substance Cellular Response To Stimulus Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Signaling Protein Phosphorylation Cell Cycle Response To Growth Factor Response To Stimulus Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Developmental Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Process Neurotrophin Signaling Pathway Innate Immune Response Intracellular Transport Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Death Cellular Response To Organonitrogen Compound Signal Transduction Cellular Response To Growth Factor Stimulus Phosphorylation Cellular Localization Cellular Response To Insulin Stimulus Anatomical Structure Development Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Immune System Process Regulation Of Metabolic Process	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Positive Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Regulation Of Intracellular Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Protein Localization Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Membrane Organization Apoptotic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Transport Positive Regulation Of Organelle Organization Protein Targeting Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Endothelial Cell Proliferation Response To Peptide Hormone Regulation Of Apoptotic Process Regulation Of Glucose Import Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Response To Peptide Positive Regulation Of Kinase Activity Regulation Of Cell Death Positive Regulation Of Epithelial Cell Migration Regulation Of Endothelial Cell Proliferation Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus
Tagcloud ?		3gamma actb atp1a1 atp1a2 atp1a3 belong confirms constituted gb glioblastoma highlights hsp90aa1 hspa8 icpl identity isolate lethal network outside peri pump quantification redundant researches trails trying tumoral ywhag ywhaz	amounts analogs camp cyclic decreases fact feedback glp glucagonlike hit igf immunoprecipitation inhibits insulin islets mediates nonhydrolyzable pancreatic parallel phosphodiesterase secretagogues secreted secreting secretion stimulate substrates t15 turn
Tagcloud (Difference) ?		3gamma actb atp1a1 atp1a2 atp1a3 belong confirms constituted gb glioblastoma highlights hsp90aa1 hspa8 icpl identity isolate lethal network outside peri pump quantification redundant researches trails trying tumoral ywhag ywhaz	amounts analogs camp cyclic decreases fact feedback glp glucagonlike hit igf immunoprecipitation inhibits insulin islets mediates nonhydrolyzable pancreatic parallel phosphodiesterase secretagogues secreted secreting secretion stimulate substrates t15 turn
Tagcloud (Intersection) ?