UBE2V1 and BIRC2

Number of citations of the paper that reports this interaction (PMID 18570872)
166

Data Source:
BioGRID (pull down)

		UBE2V1	BIRC2
Gene Name		ubiquitin-conjugating enzyme E2 variant 1	baculoviral IAP repeat containing 2
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Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex UBC13-UEV1A Complex Protein Complex Extracellular Vesicular Exosome	XY Body Nucleus Cytoplasm Cytosol Spindle Microtubule Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein N-terminus Binding
	Biological Process	Protein Polyubiquitination Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of DNA Repair Postreplication Repair Regulation Of Transcription, DNA-templated Cell Differentiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Error-free Postreplication DNA Repair Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination	Protein Polyubiquitination Response To Hypoxia Placenta Development Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Surface Receptor Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Regulation Of Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Innate Immune Response Response To Ethanol Regulation Of Cell Differentiation Regulation Of Inflammatory Response Protein Heterooligomerization Response To CAMP Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Mitotic Spindle Assembly Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Class I MHC mediated antigen processing & presentation Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex Innate Immune System TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Adaptive Immune System	Apoptotic cleavage of cellular proteins IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Apoptotic execution phase MyD88-independent cascade Activated TLR4 signalling Toll-Like Receptors Cascades Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Programmed Cell Death Innate Immune System
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		36 interactors: ARIH2 BIRC2 BIRC3 BIRC8 CHFR DTX3 DZIP3 FAM168A KITLG MID1 MKRN3 PARK2 PELI1 PELI3 RNF10 RNF111 RNF14 RNF144A RNF185 RNF2 RNF5 RNF8 STUB1 SUMO4 TRAF2 TRAF3IP2 TRAF6 TRIM39 TRIM5 TRIM8 UBC UBE2N UBOX5 UBQLN1 XIAP ZNRF1	58 interactors: BIRC5 BIRC7 BOLA1 CASP2 CASP3 CASP7 CASP9 CBLC CD40 DIABLO DZIP3 EAF2 EXOSC5 FBXO7 GAS1 GCC1 GFAP GSPT1 HSP90B1 HTRA2 IKBKE IKBKG JUP LTBR MAGEA11 MAP3K2 MAP3K3 NMB OTUB1 PACS2 PCSK9 PPM1K RAC1 RAF1 RHOA RIPK1 RIPK2 RIPK3 RIPK4 RNF181 TRADD TRAF1 TRAF2 TRIM34 TSG101 TSGA10 UBB UBC UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2J1 UBE2Q2 UBE2S UBE2V1 UBE2W WDYHV1
Entrez ID		7335	329
HPRD ID		04294	03419
Ensembl ID		ENSG00000244687	ENSG00000110330
Uniprot IDs		Q13404	Q13490
PDB IDs		2A4D 2C2V 2HLW	1QBH 2L9M 3D9T 3D9U 3M1D 3MUP 3OZ1 3T6P 3UW4 4EB9 4HY4 4HY5 4LGE 4LGU
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Cellular Protein Modification Process Protein K63-linked Ubiquitination Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Protein K48-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Protein Autoubiquitination Activation Of Innate Immune Response Protein Catabolic Process Regulation Of Innate Immune Response Ubiquitin-dependent Protein Catabolic Process Regulation Of Signaling Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Cellular Protein Catabolic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Intracellular Signal Transduction Cellular Macromolecule Catabolic Process Cellular Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Innate Immune Response Immune Response Regulation Of Protein Metabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Catabolic Process Positive Regulation Of Protein Metabolic Process Defense Response Response To Stress	Programmed Cell Death Cell Death Death Apoptotic Process Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Activation Of Innate Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Innate Immune Response Protein Ubiquitination Cellular Response To Stress Regulation Of Cell Death Protein Modification By Small Protein Conjugation Positive Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Protein Processing Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Death Protein Catabolic Process Cellular Macromolecule Catabolic Process Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Transferase Activity Response To Stress Cellular Protein Catabolic Process Cellular Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Cellular Protein Metabolic Process
Tagcloud ?		activate autophosphorylation catalyse chains conjugated conjugating deubiquitination disassembly emanating ikk il1r lys map3k7 map3k7ip2 phosphorylates polyubiquitin polyubiquitinated polyubiquitination reconstituting tab2 tak1 toll traf6 ubc13 ubch5c ube2d3 ube2n uev1a unanchored	2b arrest baculoviral c4 caspases cdk2 ciap1 consumer deacetylases dependently du ester hdacs immortalized lncap maa malformation methoxyacetic named p63 p73 pharmaceutical phthalates prns prostatic rwpe spermatocyte suppresses turning
Tagcloud (Difference) ?		activate autophosphorylation catalyse chains conjugated conjugating deubiquitination disassembly emanating ikk il1r lys map3k7 map3k7ip2 phosphorylates polyubiquitin polyubiquitinated polyubiquitination reconstituting tab2 tak1 toll traf6 ubc13 ubch5c ube2d3 ube2n uev1a unanchored	2b arrest baculoviral c4 caspases cdk2 ciap1 consumer deacetylases dependently du ester hdacs immortalized lncap maa malformation methoxyacetic named p63 p73 pharmaceutical phthalates prns prostatic rwpe spermatocyte suppresses turning
Tagcloud (Intersection) ?