UBE2E2 and TRIM32

Number of citations of the paper that reports this interaction (PMID 21143188)
10

Data Source:
BioGRID (two hybrid, two hybrid)

		UBE2E2	TRIM32
Gene Name		ubiquitin-conjugating enzyme E2E 2	tripartite motif containing 32
Image
Gene Ontology Annotations	Cellular Component		Nucleus Cytoplasm Cytosol Striated Muscle Myosin Thick Filament
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Myosin Binding Tat Protein Binding Translation Initiation Factor Binding Ubiquitin Binding Protein Self-association Ubiquitin Protein Ligase Activity
	Biological Process	Cellular Response To DNA Damage Stimulus ISG15-protein Conjugation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Protein Polyubiquitination Response To UV Protein Ubiquitination Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Response To Tumor Necrosis Factor Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cell Motility
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Regulation of innate immune responses to cytosolic DNA Cytosolic sensors of pathogen-associated DNA Class I MHC mediated antigen processing & presentation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		61 interactors: APP ARIH1 ARIH2 ARRDC3 BARD1 BRCA1 CHFR CUL3 CUL9 DAZAP2 DTX3 DTX3L DZIP3 FAM9B FHL1 IPO11 ISG15 MARCH3 MDM2 MID1 MID2 MKRN3 MUL1 NFE2L2 PCGF2 PRAM1 RING1 RLIM RNF10 RNF103 RNF11 RNF111 RNF114 RNF125 RNF14 RNF166 RNF185 RNF19A RNF2 RNF25 RNF4 RNF5 RNF8 SRPK1 SRPK2 STUB1 TRIM2 TRIM23 TRIM27 TRIM28 TRIM31 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBOX5 XIAP ZNRF1	36 interactors: ABI2 ATXN1 CLIP4 DTNBP1 GLIS2 IRAK1 KCTD9 MID2 MYCN PDE9A PIAS3 PIAS4 PTCD2 PTPN11 RABAC1 RNF208 RNF41 SCGB1A1 SDCBP SYT6 TMEM173 TOP1 TRIM23 TRIM27 TRIM5 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2U UBQLN1 UBQLN4 VPS11 XIAP
Entrez ID		7325	22954
HPRD ID		06779	03797
Ensembl ID			ENSG00000119401
Uniprot IDs		Q96LR5	Q13049
PDB IDs		1Y6L	2CT2
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Metabolic Process Negative Regulation Of Viral Process Protein Autoubiquitination Catabolic Process Regulation Of Viral Process Proteolysis Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Viral Release From Host Cell Metabolic Process Histone Ubiquitination Negative Regulation Of Cellular Metabolic Process Histone H2A Ubiquitination Innate Immune Response Negative Regulation Of Viral Release From Host Cell Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Proteasomal Protein Catabolic Process Negative Regulation Of Viral Transcription Response To Stress Regulation Of Protein Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response Regulation Of Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Cellular Response To Stress Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Defense Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Protein K48-linked Ubiquitination Regulation Of Innate Immune Response Cellular Protein Modification Process Activation Of Innate Immune Response Protein K63-linked Ubiquitination Positive Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Metabolic Process Cellular Response To Oxygen Levels Cellular Protein Metabolic Process Regulation Of Immune System Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response Innate Immune Response-activating Signal Transduction Negative Regulation Of Viral Release From Host Cell TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Response To Stimulus Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Viral Release From Host Cell Protein K11-linked Ubiquitination Response To Stress Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor Signaling Pathway Regulation Of Gene Expression Proteasomal Protein Catabolic Process Protein Metabolic Process ISG15-protein Conjugation Immune Response-regulating Signaling Pathway Immune Response Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Defense Response Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Stimulus Cellular Protein Catabolic Process Regulation Of RNA Metabolic Process
Tagcloud ?		3p24 amino assigned bond cdna conjugating drosophila e1 encoding enzyme extension fluorescence formed hybridization identity kb product shares similarity thioester transcribed transcript ubc ubcd2 ubch6 ubch8 ubcm2 ubiquitin	arrest binds e3 element ensure impairing interacts largely ligase maintaining modifications negatively oncogenic overexpressed p53 preventing promotes proper regulator responsive senescence stress tightly transcriptionally translational tumorigenesis turn ubiquitin ubiquitination
Tagcloud (Difference) ?		3p24 amino assigned bond cdna conjugating drosophila e1 encoding enzyme extension fluorescence formed hybridization identity kb product shares similarity thioester transcribed transcript ubc ubcd2 ubch6 ubch8 ubcm2	arrest binds e3 element ensure impairing interacts largely ligase maintaining modifications negatively oncogenic overexpressed p53 preventing promotes proper regulator responsive senescence stress tightly transcriptionally translational tumorigenesis turn ubiquitination
Tagcloud (Intersection) ?		ubiquitin