UBE2D1 and CTNNB1

Number of citations of the paper that reports this interaction (PMID 18851830)
118

Data Source:
BioGRID (pull down)

		UBE2D1	CTNNB1
Gene Name		ubiquitin-conjugating enzyme E2D 1	catenin (cadherin-associated protein), beta 1, 88kDa
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Cytosol Protein Complex	Spindle Pole Nucleus Nucleoplasm Transcription Factor Complex Nuclear Euchromatin Cytoplasm Centrosome Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Cell-cell Adherens Junction Fascia Adherens Tight Junction Focal Adhesion Cell Cortex Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Lamellipodium Cell Junction Beta-catenin Destruction Complex Microvillus Membrane Protein-DNA Complex Scrib-APC-beta-catenin Complex Dendritic Shaft Apical Part Of Cell Synapse Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Beta-catenin-TCF7L2 Complex Cell Periphery
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin Conjugating Enzyme Activity	RNA Polymerase II Activating Transcription Factor Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Signal Transducer Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Enzyme Binding Kinase Binding Protein Phosphatase Binding Estrogen Receptor Binding Protein Complex Binding Ionotropic Glutamate Receptor Binding Nuclear Hormone Receptor Binding Transcription Regulatory Region DNA Binding Ion Channel Binding Alpha-catenin Binding Cadherin Binding SMAD Binding Androgen Receptor Binding Nitric-oxide Synthase Binding I-SMAD Binding R-SMAD Binding Repressing Transcription Factor Binding Euchromatin Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Polyubiquitination Mitotic Cell Cycle Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression BMP Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K48-linked Ubiquitination Cellular Response To Hypoxia	Negative Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Axis Specification Patterning Of Blood Vessels Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Cell Fate Specification Endodermal Cell Fate Commitment Neuron Migration Epithelial To Mesenchymal Transition Neural Plate Development Liver Development Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Lens Morphogenesis In Camera-type Eye Regulation Of Secondary Heart Field Cardioblast Proliferation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transcription, DNA-templated Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Adhesion Cell-matrix Adhesion Ectoderm Development Glial Cell Fate Determination Midgut Development Negative Regulation Of Cell Proliferation Anterior/posterior Axis Specification Dorsal/ventral Axis Specification Proximal/distal Pattern Formation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Schwann Cell Proliferation Wnt Signaling Pathway Single Organismal Cell-cell Adhesion Stem Cell Maintenance Layer Formation In Cerebral Cortex Central Nervous System Vasculogenesis Osteoclast Differentiation Androgen Receptor Signaling Pathway Male Genitalia Development Regulation Of Centriole-centriole Cohesion Pancreas Development Hair Follicle Morphogenesis Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Type I Interferon Production T Cell Differentiation In Thymus Negative Regulation Of Protein Sumoylation Response To Cytokine Adherens Junction Assembly Protein Localization To Cell Surface Embryonic Heart Tube Development Genitalia Morphogenesis Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Embryonic Skeletal Limb Joint Morphogenesis Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Response To Drug Regulation Of Cell Fate Specification Muscle Cell Differentiation Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Innate Immune Response Myoblast Differentiation Bone Resorption Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Mitotic Cell Cycle, Embryonic Response To Cadmium Ion Regulation Of Fibroblast Proliferation Cell Maturation Synaptic Vesicle Transport Thymus Development Oocyte Development Embryonic Foregut Morphogenesis Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Oligodendrocyte Differentiation Synapse Organization Smooth Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Protein Heterooligomerization Positive Regulation Of Histone H3-K4 Methylation Oviduct Development Canonical Wnt Signaling Pathway Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Lung Cell Differentiation Lung-associated Mesenchyme Development Lung Induction Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Hair Follicle Placode Formation Mesenchymal Cell Proliferation Involved In Lung Development Endothelial Tube Morphogenesis Fungiform Papilla Formation Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Sympathetic Ganglion Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Mechanical Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Indole-3-methanol Renal Vesicle Formation Renal Inner Medulla Development Renal Outer Medulla Development Nephron Tubule Formation Regulation Of Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Calcium Ion Import Negative Regulation Of Neuron Death Cellular Response To Insulin-like Growth Factor Stimulus Regulation Of Protein Localization To Cell Surface Positive Regulation Of Determination Of Dorsal Identity Positive Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer Phosphorylation of the APC/C Negative regulators of RIG-I/MDA5 signaling Cellular Senescence SMAD2/3 MH2 Domain Mutants in Cancer APC/C:Cdc20 mediated degradation of Securin Downregulation of SMAD2/3:SMAD4 transcriptional activity Signaling by BMP Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer TRIF-mediated TLR3/TLR4 signaling Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Loss of Function of SMAD4 in Cancer Senescence-Associated Secretory Phenotype (SASP) TGFBR1 KD Mutants in Cancer APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System Cellular response to hypoxia APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Regulation of Hypoxia-inducible Factor (HIF) by oxygen Separation of Sister Chromatids Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Inactivation of APC/C via direct inhibition of the APC/C complex Mitotic Anaphase TGFBR1 LBD Mutants in Cancer M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Activated TLR4 signalling Class I MHC mediated antigen processing & presentation Innate Immune System Loss of Function of SMAD2/3 in Cancer IKK complex recruitment mediated by RIP1 TGFBR2 Kinase Domain Mutants in Cancer MyD88-independent cascade Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Regulation of mitotic cell cycle Cell Cycle Checkpoints SMAD4 MH2 Domain Mutants in Cancer	APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt binding of TCF/LEF:CTNNB1 to target gene promoters deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation S33 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN Innate Immune System truncations of AMER1 destabilize the destruction complex CDO in myogenesis misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Cytosolic sensors of pathogen-associated DNA formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes beta-catenin independent WNT signaling deletions in the AMER1 gene destabilize the destruction complex Ca2+ pathway Myogenesis AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs			Urea
Diseases
GWAS		Brain imaging ( 20100581) Crohn's disease ( 21102463)	Bone mineral density ( 22504420) Bone mineral density (hip) ( 19801982)
Protein-Protein Interactions		193 interactors: AMFR ANAPC11 ANXA1 ANXA7 AREL1 ARIH1 ARIH2 ASB2 ASB4 ASB9 BARD1 BFAR BIRC2 BIRC3 BIRC6 BIRC7 BIRC8 BRCA1 BRCC3 BRE BRMS1 C7orf25 CADPS2 CBL CBLC CDK7 CDKN1A CHFR CNOT4 CREBBP CRYAB CTNNB1 CUL2 CUL3 DDX58 DTL DTX1 DTX2 DTX3 DTX3L DZIP3 EP300 EPS15 F12 FAF2 FBXO2 FBXW7 FOS FZR1 GADD45A GSK3B HDAC6 HERC3 HERC5 HIF1A HSD17B10 HUWE1 KAT2B KDM2B KLHL13 KLHL2 KLHL9 LRSAM1 MAP3K1 MARCH1 MARCH2 MARCH4 MARCH5 MARCH7 MARCH8 MDM2 MDM4 MGRN1 MIB1 MID1 MID2 MKNK1 MKRN2 MKRN3 MUL1 MYLIP NBN NEDD4 NEDD4L NEURL1 NFKBIA NHLRC1 NR1H2 OTUB1 PELI1 PJA2 POLL POLM RABGEF1 RAD23A RBX1 RELA RFFL RFWD2 RFWD3 RING1 RLIM RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF125 RNF126 RNF128 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF182 RNF185 RNF2 RNF25 RNF26 RNF31 RNF38 RNF4 RNF43 RNF5 RNF6 RNF7 RNF8 SH3RF1 SIAH1 SIAH2 SIRT6 SIVA1 SKP1 SMURF2 STAM2 STUB1 TAF1D TBL1X TNFAIP3 TNNT1 TOM1 TOPORS TP53 TRAF2 TRAF6 TRAF7 TRAIP TRIM10 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM31 TRIM32 TRIM35 TRIM37 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM55 TRIM63 TRIM7 TRIM8 TRIP12 TSC22D1 UBA1 UBA6 UBASH3B UBC UBE3A UBE3C UBE4A UBOX5 UFM1 UHRF2 VHL XIAP ZNRF1 ZNRF2 ZNRF4	172 interactors: ACP1 AJAP1 AKT1 AMER1 APC APC2 APP AR ARHGAP32 ASH2L AXIN1 AXIN2 BCL3 BCL9 BCL9L BOC BRCA1 BTRC CA9 CARM1 CASP3 CASP8 CBL CBY1 CCND1 CDC27 CDC73 CDH1 CDH11 CDH15 CDH16 CDH2 CDH24 CDH3 CDH5 CDH7 CDH8 CDH9 CDK2 CDK5R1 CDK6 CDON CEBPA CHD8 CHUK CREBBP CSNK1A1 CSNK1D CSNK2A1 CSNK2B CTNNA1 CTNNA3 CTNNBIP1 CTNND2 DLG5 DSC3 DVL1 DVL3 EGFR ELAVL1 EP300 ERBB2 ERBB2IP ESR1 EZR FER FHIT FHL2 FLT1 FOXO1 FOXO4 FSCN1 FUS FYN GLIS2 GNA13 GRIK2 GRIN1 GRIN2D GSK3B HDAC6 HIF1A HIST1H1C HNF1A IGF2BP1 IKBKB IQGAP1 JADE1 KAT2A KAT2B KDR KMT2A KMT2D LATS2 LEF1 LEO1 MAGI1 MAGI2 MAPK8 MAPK9 MEN1 MET MITF MUC1 NCOA2 NDRG1 NEK2 NEURL2 NF2 NFKB1 NOTCH1 NR5A1 PECAM1 PICK1 PIK3R1 PIN1 PITX2 PKD1 PKP2 PLK1 PPM1A PSEN1 PSEN2 PTGS2 PTPN1 PTPN13 PTPN14 PTPN6 PTPRF PTPRJ PTPRK PTPRM PTPRU PTPRZ1 PYGO1 RAPGEF2 RBBP5 RBX1 RUVBL1 RUVBL2 RXRA SALL1 SIAH1 SKP1 SLC9A3R1 SMAD2 SMAD3 SMAD4 SMAD7 SMARCA4 SMARCA5 SOX1 SOX17 SPN SRC TAX1BP3 TBL1X TCF3 TCF4 TCF7L1 TCF7L2 TFAP2A TGFBR1 TGFBR2 TLE1 TRIP10 TRRAP UBE2B UBE2D1 UHRF2 USP9X ZFYVE9
Entrez ID		7321	1499
HPRD ID		04267	00286
Ensembl ID		ENSG00000072401	ENSG00000168036
Uniprot IDs		P51668	P35222
PDB IDs		2C4P 2YHO 3OJ4 3PTF 4AP4	1G3J 1JDH 1JPW 1LUJ 1P22 1QZ7 1T08 1TH1 2G57 2GL7 2Z6H 3DIW 3FQN 3FQR 3SL9 3SLA 3TX7 4DJS
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Catabolic Process Cellular Metabolic Process Cellular Macromolecule Catabolic Process Protein Autoubiquitination Proteolysis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Monoubiquitination Cellular Response To Stress Metabolic Process Regulation Of Protein Metabolic Process Response To Stress Protein K48-linked Ubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Proteasomal Protein Catabolic Process Programmed Cell Death Cell Death Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Ubiquitination Negative Regulation Of Viral Release From Host Cell Regulation Of Viral Release From Host Cell Cellular Process Protein K63-linked Ubiquitination Regulation Of Signal Transduction Regulation Of Metabolic Process Cellular Response To Stimulus Regulation Of Apoptotic Process Innate Immune Response Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Stimulus Regulation Of Signaling	Positive Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Gene Expression Signaling Cell Communication Signal Transduction Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Development Multicellular Organismal Development Regulation Of Metabolic Process Response To Stimulus Developmental Process Negative Regulation Of Signaling Wnt Signaling Pathway Anatomical Structure Morphogenesis Cell Differentiation Negative Regulation Of Signal Transduction System Development Regulation Of Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Organ Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Tissue Development Negative Regulation Of Cellular Metabolic Process Cell Development Regulation Of Wnt Signaling Pathway Regulation Of Cell Differentiation Regulation Of Cellular Process Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Epithelium Development Regulation Of RNA Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		accumulation apoptosis apoptotic arsenic cadmium conjugating degradation downregulation elevated enzymes family hand induce inorganic mercury p53 promote proteasomal proximal rat suppressed suppression tubular ubiquitin ubiquitination	acc acquires adrenal adrenocortical altering came centripetal compr cortex detail examining exome gland igf2 landscape medulla mutational opening perspectives physiol played prognostication progress steroidogenic subcapsular summarizes tracing zonation zones
Tagcloud (Difference) ?		accumulation apoptosis apoptotic arsenic cadmium conjugating degradation downregulation elevated enzymes family hand induce inorganic mercury p53 promote proteasomal proximal rat suppressed suppression tubular ubiquitin ubiquitination	acc acquires adrenal adrenocortical altering came centripetal compr cortex detail examining exome gland igf2 landscape medulla mutational opening perspectives physiol played prognostication progress steroidogenic subcapsular summarizes tracing zonation zones
Tagcloud (Intersection) ?