TSHR and RABAC1

Number of citations of the paper that reports this interaction (PMID 14604818)
3

Data Source:
HPRD (two hybrid)

		TSHR	RABAC1
Gene Name		thyroid stimulating hormone receptor	Rab acceptor 1 (prenylated)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Golgi Apparatus Plasma Membrane Synaptic Vesicle Membrane Integral Component Of Membrane Cell Junction
	Molecular Function	Thyroid-stimulating Hormone Receptor Activity Protein Binding	Protein Binding Protein C-terminus Binding Identical Protein Binding Proline-rich Region Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell-cell Signaling Positive Regulation Of Cell Proliferation Thyroid-stimulating Hormone Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Thyrotropin Alfa
Diseases
GWAS		Graves' disease ( 21841780) Hair morphology ( 19896111) Optic disc size (rim) ( 20395239) Visceral fat ( 22589738)
Protein-Protein Interactions		24 interactors: ADRB2 CALR CANX FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HSPA5 JAK1 JAK2 LHCGR PIK3R1 RABAC1 SCRIB STAT3 TSHB UBC	63 interactors: ADCK3 CMTM3 CREB3 DUSP12 FAM160A2 FXR2 GDI1 HRAS HRG LNX1 MAD2L1 MCF2L MIEF2 NAT14 NDRG4 NIF3L1 NR3C2 NUDT18 PBX3 PLEKHF2 PLK1 RAB17 RAB1A RAB22A RAB33A RAB3A RAB4A RAB4B RAB5A RAB5B RAB5C RAB6A RAB7A RAP1A RASD2 REEP5 RGS2 RHEB RHOA RIC8A RIMS2 RIN3 RPS20 RRAS2 SGK1 SNCA SNX1 SNX10 SNX11 SNX15 SPG21 SYT16 TNIP1 TRIM32 TSHR TUBB2A TXN2 VAMP2 VIM VTA1 WDYHV1 WIPI2 ZFYVE21
Entrez ID		7253	10567
HPRD ID		04537	05375
Ensembl ID		ENSG00000165409	ENSG00000105404
Uniprot IDs		F5GYU5 P16473	Q9UI14
PDB IDs		1XUM 2XWT 3G04
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Platelet Activation Blood Coagulation Hemostasis Wound Healing Response To Wounding Regulation Of Body Fluid Levels Signaling Cell Communication Response To Stress Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell Activation Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Response To Stimulus Regulation Of Adenylate Cyclase Activity Developmental Process Regulation Of Cyclase Activity Cellular Response To Stimulus Regulation Of CAMP Biosynthetic Process Dopamine Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of CAMP Metabolic Process Response To Organic Substance Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Localization Anatomical Structure Development Establishment Of Localization In Cell Regulation Of Signaling Regulation Of Cell Migration Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Motility Growth Hormone Receptor Signaling Pathway Response To Hormone Cellular Response To Growth Hormone Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Cell Differentiation Multicellular Organismal Development Activation Of Adenylate Cyclase Activity Response To Cytokine Regulation Of Cellular Process Cellular Response To Organic Substance	Ras Protein Signal Transduction Rab Protein Signal Transduction Small GTPase Mediated Signal Transduction Establishment Of Protein Localization Protein Transport Protein Localization Cellular Protein Localization Cellular Localization Intracellular Protein Transport Regulation Of Cellular Component Organization Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Establishment Of Localization In Cell Intracellular Transport Intracellular Signal Transduction Endosomal Transport Regulation Of Exocytosis Transport Cellular Response To Stimulus Cell Communication Regulation Of Endocytosis Endocytosis Regulation Of Locomotion Vesicle Organization Endosome Organization Response To Stimulus Regulation Of Synaptic Vesicle Transport Regulation Of Cell Projection Organization Signaling Signal Transduction Cytoplasmic Transport Establishment Of Vesicle Localization Regulation Of Neuronal Synaptic Plasticity Vesicle Localization Regulation Of Organelle Organization Regulation Of Cell Migration Positive Regulation Of Metabolic Process Early Endosome To Late Endosome Transport Regulation Of Neurotransmitter Secretion Regulation Of Cell Motility Regulation Of Signaling Regulation Of Cellular Localization Regulation Of Cellular Component Movement Regulation Of Cellular Process Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Transport Synaptic Vesicle Recycling Endomembrane System Organization
Tagcloud ?		adenomas autonomous autonomy characterised constitutive disseminated evaluates f fdg focal focally gain goiters head hypermetabolism invoked iodine metabolism neck nodules pet radioiodine served simultaneous ten thyroid thyrotropin toxic twenty
Tagcloud (Difference) ?		adenomas autonomous autonomy characterised constitutive disseminated evaluates f fdg focal focally gain goiters head hypermetabolism invoked iodine metabolism neck nodules pet radioiodine served simultaneous ten thyroid thyrotropin toxic twenty
Tagcloud (Intersection) ?