NR2C2 and NR2C2AP

Number of citations of the paper that reports this interaction (PMID 12486131)
6

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		NR2C2	NR2C2AP
Gene Name		nuclear receptor subfamily 2, group C, member 2	nuclear receptor 2C2-associated protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Spermatogenesis Nervous System Development Gene Expression Cerebellum Development Cell Differentiation Positive Regulation Of Embryonic Development Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Behavior Meiotic Cell Cycle	Transcription Initiation From RNA Polymerase II Promoter Gene Expression
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS		Alcohol and nictotine co-dependence ( 22488850)
Protein-Protein Interactions		21 interactors: AR CD2AP CDC37 CHUK ESR1 FKBP5 HDAC4 HNF4A HSP90AA1 HSP90AB1 IKBKB ITSN2 JAZF1 KDM1A NR2C1 NR2C2AP PEBP1 RXRB TAB1 TAB2 TRAF2	4 interactors: NR2C2 REL SLC16A3 TCF4
Entrez ID		7182	126382
HPRD ID		03253	16376
Ensembl ID			ENSG00000184162
Uniprot IDs		F2YGU2 P49116 Q6PHZ7	B4DW92 Q86WQ0
PDB IDs		3P0U
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Innate Immune Response I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor 4 Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Toll-like Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Hormone-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 5 Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Signaling Toll-like Receptor 2 Signaling Pathway Response To Organic Substance Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Regulation Of Immune Response Regulation Of Metabolic Process MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Immune Response Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway	Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process DNA-templated Transcription, Initiation Maintenance Of DNA Repeat Elements Positive Regulation Of Transcription, DNA-templated Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Embryonic Genitalia Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Myoblast Fate Commitment Lactate Transmembrane Transport Plasma Membrane Lactate Transport Lactate Transport Secretory Granule Localization Regulation Of Transcription From RNA Polymerase II Promoter Hindgut Morphogenesis Insulin Metabolic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Hindgut Development Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Glycoprotein Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Gluconeogenesis Regulation Of Triglyceride Biosynthetic Process Genitalia Morphogenesis Transcription, DNA-templated Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway RNA Biosynthetic Process Response To Organic Substance Embryonic Digestive Tract Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Embryonic Development Regulation Of Protein Export From Nucleus Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Glucose Metabolic Process Regulation Of Triglyceride Metabolic Process Regulation Of Hormone Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Brain Development Face Morphogenesis Negative Regulation Of Organ Growth
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