TOP2A and PRKCB

Number of citations of the paper that reports this interaction (PMID 12569090)
9

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro, in vivo)

		TOP2A	PRKCB
Gene Name		topoisomerase (DNA) II alpha 170kDa	protein kinase C, beta
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Condensed Chromosome Nucleus Nucleoplasm Nucleolus Centriole Nucleoid DNA Topoisomerase Complex (ATP-hydrolyzing) Viral Integration Complex Protein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding DNA Binding Chromatin Binding DNA Topoisomerase Type II (ATP-hydrolyzing) Activity Protein Kinase C Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Drug Binding DNA Binding, Bending Enzyme Binding Protein Homodimerization Activity Histone Deacetylase Binding Ubiquitin Binding Poly(A) RNA Binding Protein Heterodimerization Activity	Chromatin Binding Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Kinase C Binding Calcium Channel Regulator Activity Protein Binding ATP Binding Zinc Ion Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T6 Specific) Histone Binding Androgen Receptor Binding
	Biological Process	Mitotic Cell Cycle Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Hematopoietic Progenitor Cell Differentiation DNA Topological Change DNA Ligation DNA Unwinding Involved In DNA Replication Mitotic Recombination Cellular Response To DNA Damage Stimulus Chromosome Segregation Apoptotic Chromosome Condensation Embryonic Cleavage Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Mitotic DNA Integrity Checkpoint Positive Regulation Of Viral Genome Replication Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription From RNA Polymerase II Promoter	Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Apoptotic Process Mitotic Nuclear Envelope Disassembly Signal Transduction Synaptic Transmission Blood Coagulation Negative Regulation Of Glucose Transport Platelet Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Histone H3-T6 Phosphorylation Intracellular Signal Transduction B Cell Activation Lipoprotein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Angiogenesis Negative Regulation Of Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Carbohydrate Stimulus
Pathways		G0 and Early G1 Mitotic G1-G1/S phases Cell Cycle, Mitotic	Signaling by the B Cell Receptor (BCR) Trafficking of GluR2-containing AMPA receptors Signaling by GPCR Mitotic Prophase Nuclear Envelope Breakdown Signaling by Wnt VEGFA-VEGFR2 Pathway M Phase Downstream signaling events of B Cell Receptor (BCR) VEGFR2 mediated cell proliferation Response to elevated platelet cytosolic Ca2+ G alpha (z) signalling events Disinhibition of SNARE formation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Depolymerisation of the Nuclear Lamina Trafficking of AMPA receptors Cell Cycle, Mitotic beta-catenin independent WNT signaling GPCR downstream signaling Signaling by VEGF Activation of NF-kappaB in B cells WNT5A-dependent internalization of FZD4 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Platelet activation, signaling and aggregation PCP/CE pathway Adaptive Immune System Transmission across Chemical Synapses
Drugs		Moxifloxacin Amsacrine Dexrazoxane Valrubicin Teniposide Epirubicin Enoxacin Pefloxacin Ciprofloxacin Trovafloxacin Daunorubicin Etoposide Lomefloxacin Doxorubicin Norfloxacin Levofloxacin Ofloxacin Idarubicin Podofilox Mitoxantrone Sparfloxacin Genistein Fleroxacin Lucanthone	Vitamin E O-Phosphoethanolamine Ellagic Acid
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		22 interactors: BRCA1 CDK1 COPS5 CSNK2A1 DFFB DHX9 HDAC1 HDAC2 JUN MAPK1 PIN1 PRKCA PRKCB PRKCG RB1 SRPK1 SUMO1 SUMO4 TOP2B TP53 XPO1 YWHAE	83 interactors: ADRBK1 AFAP1 ANXA2 ANXA7 BMPR2 BTK CARD11 CASR CD5 CHAT CHUK CISH CSF2RB CYTH2 DAB2 DVL2 EGFR EIF4E EIF6 EP300 EPB41 GABRB2 GABRG2 GAP43 GCNT1 GJA1 GNA12 GNA13 GNB2L1 GRIN1 GRIN2B GRIN2D GRM5 GSK3A GSK3B H1F0 HABP4 HIST1H1A HIST1H1B HIST1H3A HSPA4 IBTK IFNAR2 IKBKB IKBKG ITGB2 ITGB7 KIT LMNB1 LST1 MAPK6 MARCKS MBP MKI67 NCF1 NRGN NUMB PA2G4 PDLIM5 PDLIM7 PDPK1 PEBP1 PPP1CA PPP2CB PPP2R4 PTPN11 RASGRP3 RB1 RGS2 RIPK4 RRAD SDC2 SPTAN1 STXBP1 SYT6 TERF1 TIAM1 TINF2 TOP2A TRIM41 VTN YWHAG ZMYND8
Entrez ID		7153	5579
HPRD ID		00536	01499
Ensembl ID		ENSG00000131747	ENSG00000166501
Uniprot IDs		P11388	P05771
PDB IDs		1LWZ 1ZXM 1ZXN 4FM9	2I0E
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Cell Cycle Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Response To Growth Factor Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Apoptotic Process Regulation Of Signaling Programmed Cell Death Chromosome Organization Mitotic Cell Cycle Regulation Of Protein Metabolic Process Cell Death Death Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Organelle Organization Response To Wounding Rhythmic Process Response To Stress Innate Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Organelle Organization Cell Cycle Checkpoint Negative Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Negative Regulation Of Programmed Cell Death Signal Transduction Cellular Protein Modification Process Blood Coagulation Nucleobase-containing Compound Metabolic Process Immune Response Nucleus Organization Hemostasis Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Mitotic Cell Cycle Process Negative Regulation Of Cell Death Peptidyl-threonine Phosphorylation Developmental Process Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	Regulation Of Cellular Component Organization Regulation Of Signaling Developmental Process Regulation Of Cellular Process Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Anatomical Structure Development Programmed Cell Death Multicellular Organismal Development Signaling Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Death Death Cell Communication Apoptotic Process Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Anatomical Structure Morphogenesis Response To Stimulus Response To External Stimulus Regulation Of Signal Transduction Response To Organic Substance Intracellular Signal Transduction Regulation Of Protein Phosphorylation Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Morphogenesis Response To Fibroblast Growth Factor System Development Innate Immune Response Response To Stress Fc Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Immune System Process Fibroblast Growth Factor Receptor Signaling Pathway Cellular Process Generation Of Neurons Regulation Of Kinase Activity Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Regulation Of Metabolic Process Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?		adjacent adr adriamycin allelic antineoplastic chimeric chromatin close decondensed description disruption fibers fish fluorescence fusion hybridization juxtaposition metaphase murine proximity rara rearrangement resistant separate situ topoisomerase transcript truncated	axin2 axonogenesis cntn1 coding dendritogenesis interplay inverse maintaining maturing microrna micrornas mrnas ncam1 negr1 neurite neurotrophin nrxn1 ontology orchestrated pruning represented respective rnas sh2b3 synaptogenesis temporally tightly transcriptome verification
Tagcloud (Difference) ?		adjacent adr adriamycin allelic antineoplastic chimeric chromatin close decondensed description disruption fibers fish fluorescence fusion hybridization juxtaposition metaphase murine proximity rara rearrangement resistant separate situ topoisomerase transcript truncated	axin2 axonogenesis cntn1 coding dendritogenesis interplay inverse maintaining maturing microrna micrornas mrnas ncam1 negr1 neurite neurotrophin nrxn1 ontology orchestrated pruning represented respective rnas sh2b3 synaptogenesis temporally tightly transcriptome verification
Tagcloud (Intersection) ?