C1QA and C1R

Number of citations of the paper that reports this interaction (PMID 10878362)
11

Data Source:
HPRD (in vitro)

		C1QA	C1R
Gene Name		complement component 1, q subcomponent, A chain	complement component 1, r subcomponent
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Extracellular Vesicular Exosome	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Serine-type Peptidase Activity
	Biological Process	Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Innate Immune Response	Proteolysis Immune Response Complement Activation Complement Activation, Classical Pathway Innate Immune Response
Pathways		Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System	Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HRG PIAS2 PPP1CA PPP1CC PTX3 SGTA SLC25A47 UBQLN1 UBQLN2	7 interactors: C1QA C1QB C1S CSNK2A1 EP300 PCK1 SERPING1
Entrez ID		712	715
HPRD ID		00393	01954
Ensembl ID		ENSG00000173372
Uniprot IDs		P02745	P00736
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV	1APQ 1GPZ 1MD7 1MD8 2QY0
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Defense Response Protein Metabolic Process Positive Regulation Of Immune Response Immune System Process Innate Immune Response Response To Stress Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Response Regulation Of Immune System Process Acute-phase Response Response To Stimulus Regulation Of Protein Metabolic Process Dermatan Sulfate Biosynthetic Process Opsonization Regulation Of Acute Inflammatory Response Acute Inflammatory Response Negative Regulation Of Signal Transduction Negative Regulation Of Glycoprotein Metabolic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Negative Regulation Of Signaling Extracellular Matrix Disassembly Negative Regulation Of Viral Entry Into Host Cell Proteoglycan Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Metabolic Process Regulation Of Viral Entry Into Host Cell Triglyceride Catabolic Process Chondroitin Sulfate Biosynthetic Process Entrainment Of Circadian Clock By Photoperiod Wound Healing Chondroitin Sulfate Proteoglycan Biosynthetic Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process	Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Innate Immune Response Immune Response Defense Response Positive Regulation Of Immune Response Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Immune System Process Regulation Of Immune System Process Histone H2B Acetylation Glycerol Biosynthetic Process From Pyruvate Internal Protein Amino Acid Acetylation Negative Regulation Of Complement Activation, Lectin Pathway Response To Stimulus Protein Acetylation N-terminal Peptidyl-lysine Acetylation Glycerol Biosynthetic Process Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Regulation Of Tubulin Deacetylation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Positive Regulation By Host Of Viral Transcription Rhythmic Process N-terminal Protein Amino Acid Acetylation Negative Regulation Of Complement Activation Negative Regulation Of Proteolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Protein Processing Oxaloacetate Metabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Androgen Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification
Tagcloud ?		abeta affect allele alzheimer appps1 burden conferred copies copy deposition developing il1a influences intrem2 marked microglia microglial month morphological nos2 old pathology phagocytic plaque thought towards trem2 trends variant	a2 allogeneic autologous candidates cold ctl ctls demonstrating encoded epitopes gastric her2 hla ic50 immunodominance immunotherapy implicate lymphocyte lysed naturally neu processed recognized repetitive restricted sensitize sw626 tal transfected
Tagcloud (Difference) ?		abeta affect allele alzheimer appps1 burden conferred copies copy deposition developing il1a influences intrem2 marked microglia microglial month morphological nos2 old pathology phagocytic plaque thought towards trem2 trends variant	a2 allogeneic autologous candidates cold ctl ctls demonstrating encoded epitopes gastric her2 hla ic50 immunodominance immunotherapy implicate lymphocyte lysed naturally neu processed recognized repetitive restricted sensitize sw626 tal transfected
Tagcloud (Intersection) ?