THRA and CUL1

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		THRA	CUL1
Gene Name		thyroid hormone receptor, alpha	cullin 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	Steroid Receptor RNA Activator RNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Thyroid Hormone Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Protein Complex Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Thyroid Hormone Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Cartilage Condensation Ossification Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Gene Expression Positive Regulation Of Myotube Differentiation Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Erythrocyte Differentiation Intracellular Receptor Signaling Pathway Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Cytoplasmic Sequestering Of Transcription Factor Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Negative Regulation Of DNA-templated Transcription, Initiation	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Monoubiquitination Cell Cycle Arrest Notch Signaling Pathway Circadian Rhythm Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Viral Process Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	Signaling by the B Cell Receptor (BCR) Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Cyclin E associated events during G1/S transition Signaling by Wnt Regulation of PLK1 Activity at G2/M Transition Downstream signaling events of B Cell Receptor (BCR) Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Degradation of beta-catenin by the destruction complex G1/S Transition AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 in Cancer Prolactin receptor signaling Mitotic G1-G1/S phases truncations of AMER1 destabilize the destruction complex Signaling by NOTCH phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase S Phase Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Signaling by Interleukins SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Interleukin-1 signaling Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G2-G2/M phases Constitutive Signaling by NOTCH1 PEST Domain Mutants Adaptive Immune System Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer APC truncation mutants have impaired AXIN binding G2/M Transition APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Signaling by NOTCH1 Class I MHC mediated antigen processing & presentation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FBXW7 Mutants and NOTCH1 in Cancer G1 Phase Cytokine Signaling in Immune system Cell Cycle, Mitotic NOTCH1 Intracellular Domain Regulates Transcription Cyclin D associated events in G1 Nuclear signaling by ERBB4 Activation of NF-kappaB in B cells SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Signaling by Hedgehog deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Degradation of GLI1 by the proteasome Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs		Liothyronine Levothyroxine Dextrothyroxine Liotrix 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid
Diseases
GWAS		White blood cell count ( 21738480)
Protein-Protein Interactions		56 interactors: AKAP13 AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CDK7 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A NCOA1 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SEPP1 SLC16A2 SRC SUV39H1 TBL1X TDG TRIM24 TRIP11 YWHAH YWHAQ ZBTB3	55 interactors: ARIH1 BTRC CAND1 CDC34 CDCA3 CDK9 CDKN1B CENPE CHEK1 CHUK CKS1B COMMD1 COPS2 COPS5 COPS6 COPS7A COPS8 DCUN1D4 E2F1 FBXO18 FBXO25 FBXW11 FBXW2 FBXW4 FBXW7 GLMN GPS1 HIPK2 NEDD8 NFKBIA NFKBIB NFKBIE NLK NR1D2 PARK2 PPP1CA PRPF40A PSMB4 PSMD4 PTTG1 RAC2 RANBP2 RBX1 RICTOR RNF7 SENP8 SKP1 SKP2 SMAD3 THRA TRIM21 UBE2E3 UBE2F UBE2M ZC3HC1
Entrez ID		7067	8454
HPRD ID		07185	04389
Ensembl ID		ENSG00000126351	ENSG00000055130
Uniprot IDs		P10827 Q6FH41	B3KTW0 Q13616
PDB IDs		1NAV 2H77 2H79 3HZF 3ILZ 3JZB	1LDJ 1LDK 1U6G 3RTR 3TDU 3TDZ 4F52
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Rhythmic Process Organ Development Multicellular Organismal Development Regulation Of Cellular Process Anatomical Structure Development Developmental Process Cellular Response To Organic Substance Signal Transduction Chromosome Organization Signaling System Development	Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Protein Ubiquitination Cellular Protein Metabolic Process Protein Deneddylation Protein Metabolic Process Cullin Deneddylation Cell Cycle Mitotic Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Protein Neddylation Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Proteolysis Involved In Cellular Protein Catabolic Process Proteasomal Protein Catabolic Process Cell Cycle Phase Transition Cellular Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Protein Polyubiquitination Cellular Response To Organic Substance Cellular Macromolecule Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Viral Process Cellular Response To Stimulus Response To Growth Factor Response To Organic Substance Cell Communication Protein Modification By Small Protein Removal Negative Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Regulation Of Signaling Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Regulation Of Protein Ubiquitination Signal Transduction
Tagcloud ?		accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate	autophagy box catalytic cdk checkpoint complexes cullin1 damage degradation downstream endocytosis f fbxl20 mediates mitotic phosphatidylinositol promote proteasomal provides ptdins3 ptdins3p regulate scf skp1 sorting transduction ubiquitination vacuolar vps34
Tagcloud (Difference) ?		accounts averages bimodality bxd bxh chr counted encode ganglion heritable hoxb idea inbred krt1 lod mapped neuregulin nnc1 opposed qtl qtls retina retinal striking subsidiary surprisingly thyroxine trait vertebrate	autophagy box catalytic cdk checkpoint complexes cullin1 damage degradation downstream endocytosis f fbxl20 mediates mitotic phosphatidylinositol promote proteasomal provides ptdins3 ptdins3p regulate scf skp1 sorting transduction ubiquitination vacuolar vps34
Tagcloud (Intersection) ?