SYK and CD3E

Number of citations of the paper that reports this interaction (PMID 7761456)
21

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		SYK	CD3E
Gene Name		spleen tyrosine kinase	CD3e molecule, epsilon (CD3-TCR complex)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane B Cell Receptor Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Early Phagosome T Cell Receptor Complex Protein Complex	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Integrin Binding Protein Binding ATP Binding Protein Kinase Binding	Transmembrane Signaling Receptor Activity Receptor Signaling Protein Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Receptor Signaling Complex Scaffold Activity T Cell Receptor Binding Protein Heterodimerization Activity
	Biological Process	Angiogenesis Lymph Vessel Development Adaptive Immune Response Macrophage Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response Serotonin Secretion By Platelet Protein Phosphorylation Inflammatory Response Leukocyte Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Activation Of JUN Kinase Activity Blood Coagulation Cell Proliferation Organ Morphogenesis Regulation Of Platelet Activation Viral Process Leukotriene Biosynthetic Process Platelet Activation Neutrophil Chemotaxis Regulation Of Superoxide Anion Generation Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Defense Response To Bacterium Transcription Factor Import Into Nucleus Positive Regulation Of Mast Cell Degranulation Regulation Of Neutrophil Degranulation Beta Selection Innate Immune Response Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Blood Vessel Morphogenesis Positive Regulation Of Cytokine Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Phagocytosis Positive Regulation Of Calcium-mediated Signaling B Cell Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of ERK1 And ERK2 Cascade Cellular Response To Molecule Of Fungal Origin Regulation Of Arachidonic Acid Secretion Regulation Of Platelet Aggregation	Positive Regulation Of T Cell Anergy Protein Complex Assembly Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Complex Assembly G-protein Coupled Receptor Signaling Pathway Response To Nutrient T Cell Costimulation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Apoptotic Process Negative Thymic T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Apoptotic Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) FCERI mediated MAPK activation Platelet Aggregation (Plug Formation) DAP12 signaling Regulation of signaling by CBL Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Regulation of actin dynamics for phagocytic cup formation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System DAP12 interactions Integrin alphaIIb beta3 signaling Cytokine Signaling in Immune system Role of LAT2/NTAL/LAB on calcium mobilization Signaling by Interleukins Fc epsilon receptor (FCERI) signaling GPVI-mediated activation cascade Interleukin-2 signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System	TCR signaling Downstream TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Costimulation by the CD28 family PD-1 signaling Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs		Staurosporine N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide Ellagic Acid	Muromonab
Diseases
GWAS		Multiple sclerosis ( 21833088) Prostate cancer (gene x gene interaction) ( 22219177) Type 2 diabetes ( 22456796) Vascular dementia ( 23480133)
Protein-Protein Interactions		98 interactors: APP BLNK BTK CALM1 CBL CBLB CD19 CD22 CD3E CD72 CD79A CD79B CRKL CSF2RB CSF3R CTTN DBNL DUSP3 EGFR EPOR ERBB2 ERBB3 ERBB4 FCER1G FCGR1A FCGR2A FCGR3A FCRL3 FGR FYN GAB2 GRB2 HCLS1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC6 HDAC9 HNRNPU IL15RA IL2RB ITGB2 JAK1 LAT LAX1 LCK LCP2 LYN MAP4K1 MAPK3 MAPT MS4A2 NEDD4 NFAM1 PAG1 PIK3AP1 PIK3R1 PIK3R2 PLCG1 PLCG2 POU2AF1 PRKCA PRKD1 PTK2 PTK2B PTPN6 PXN RASA1 RPS10 RPS6KA1 RPS6KB1 RPS6KB2 SELPLG SH2B2 SH2D2A SH3BP2 SHC1 SIT1 SLA SLC4A1 SNCA SRC STAT1 STAT3 STAT5A TERF1 TLR4 TNFRSF1A TRAF6 TUBA1A TUBA4A TYROBP UBASH3B UBB USP25 VAV1 VAV2	19 interactors: CD3D CD3EAP CD3G CD79B CSK LCK NCK1 NCK2 NCL PIK3R1 PTPN22 SHC1 SNTA1 SYK TOP2B TRAT1 TRB UNC119 ZAP70
Entrez ID		6850	916
HPRD ID		02514	08923
Ensembl ID		ENSG00000165025	ENSG00000198851
Uniprot IDs		A8K4G2 P43405	P07766
PDB IDs		1A81 1CSY 1CSZ 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS 3SRV 3TUB 3TUC 3TUD 3VF8 3VF9 4DFL 4DFN 4F4P 4FL1 4FL2 4FL3 4FYN 4FYO 4FZ6 4FZ7 4GFG	1A81 1SY6 1XIW 2ROL
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Immune Response Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Defense Response Fc Receptor Signaling Pathway Immune Response Signal Transduction Cellular Response To Organic Substance Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Communication Positive Regulation Of Immune Response Signaling Positive Regulation Of Immune System Process Cellular Response To Stimulus Cell Activation Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Neurotrophin Signaling Pathway Intracellular Signal Transduction Response To Stress Fc-epsilon Receptor Signaling Pathway Regulation Of Signal Transduction Response To Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Response To Stimulus ERBB Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Signaling Antigen Receptor-mediated Signaling Pathway Regulation Of Cell Activation Response To Wounding Blood Coagulation Hemostasis Wound Healing Regulation Of Body Fluid Levels Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Fibroblast Growth Factor Receptor Signaling Pathway Leukocyte Activation Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Platelet Activation Positive Regulation Of Intracellular Signal Transduction	Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune System Process Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Activation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Single Organismal Cell-cell Adhesion Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Innate Immune Response T Cell Costimulation Cell Migration Cell Motility Immune Response Regulation Of Cellular Amino Acid Metabolic Process Lymphocyte Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cellular Ketone Metabolic Process Signal Transduction Cell Adhesion T Cell Differentiation Locomotion Positive Regulation Of Signal Transduction
Tagcloud ?		belongs bind binds blotting coimmunoprecipitation contribution cytokine domains epo epor erythroid erythropoietin far homology individually interaction jak2 mediate paper participated propose recombinant regulates sh2 src tandem tyrosine tyrosines ut7	acp5 b220 calcitonin calcr cd11b cd2 cd31 cd45 cd5 ctsk dcstamp dentin dihydroxyvitamin dmp1 facs gfp gr1 haematopoietic lin mepe oscar osteocyte osteocytes resolve sclerostin sost tartrate ter119 tnfsf11
Tagcloud (Difference) ?		belongs bind binds blotting coimmunoprecipitation contribution cytokine domains epo epor erythroid erythropoietin far homology individually interaction jak2 mediate paper participated propose recombinant regulates sh2 src tandem tyrosine tyrosines ut7	acp5 b220 calcitonin calcr cd11b cd2 cd31 cd45 cd5 ctsk dcstamp dentin dihydroxyvitamin dmp1 facs gfp gr1 haematopoietic lin mepe oscar osteocyte osteocytes resolve sclerostin sost tartrate ter119 tnfsf11
Tagcloud (Intersection) ?