BRCA2 and DMC1

Number of citations of the paper that reports this interaction (PMID 17541404)
24

Data Source:
BioGRID (unspecified method)

		BRCA2	DMC1
Gene Name		breast cancer 2, early onset	DNA meiotic recombinase 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Secretory Granule BRCA2-MAGE-D1 Complex Protein Complex	Chromosome, Telomeric Region Condensed Nuclear Chromosome Nucleus Chromosome
	Molecular Function	Protease Binding Single-stranded DNA Binding Histone Acetyltransferase Activity Protein Binding H3 Histone Acetyltransferase Activity H4 Histone Acetyltransferase Activity Gamma-tubulin Binding	DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Cytokinesis Oocyte Maturation Inner Cell Mass Cell Proliferation DNA Repair Nucleotide-excision Repair Double-strand Break Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Male Meiosis I Spermatogenesis Brain Development Cell Aging Female Gonad Development Response To X-ray Response To UV-C Response To Gamma Radiation Hemopoiesis Regulation Of Cytokinesis Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Replication Fork Protection Centrosome Duplication	Ovarian Follicle Development Oocyte Maturation Meiotic Nuclear Division Synapsis Reciprocal Meiotic Recombination Male Meiosis I Spermatogenesis Spermatid Development Female Gamete Generation
Pathways		Homologous DNA pairing and strand exchange Meiotic recombination Fanconi Anemia pathway Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Presynaptic phase of homologous DNA pairing and strand exchange	Meiotic recombination
Drugs
Diseases
GWAS		Breast cancer ( 23535729 23535733)
Protein-Protein Interactions		34 interactors: ATM ATR BCCIP BRCA1 BUB1B C11orf30 CCNA2 CCNE1 CDK1 CDK2 CFAP52 CHEK2 DMC1 FANCD2 FANCE FANCG FLNA H2AFX HMG20B HNRNPC KAT2B MAGED1 NEDD4 PALB2 PLK1 RAD51 RPA1 SERPINH1 SHFM1 SMAD3 STAT5A TP53 UQCC1 USP11	10 interactors: BRCA2 GORASP2 KCTD17 NIF3L1 PSMA3 RAD51 RAD54B RPA1 SDCBP TRIM23
Entrez ID		675	11144
HPRD ID		02554	04099
Ensembl ID		ENSG00000139618	ENSG00000100206
Uniprot IDs		P51587	B4DMW6 Q14565
PDB IDs		1N0W 3EU7	1V5W 2ZJB 4HYY
Enriched GO Terms of Interacting Partners?		Cell Cycle Cellular Response To DNA Damage Stimulus Cell Cycle Process DNA Repair DNA Metabolic Process Cell Cycle Checkpoint Cellular Response To Stress Regulation Of Protein Metabolic Process DNA Damage Checkpoint Double-strand Break Repair Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle DNA Recombination Chromosome Organization Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Response To Stimulus Meiotic Cell Cycle Replicative Senescence Mitotic Cell Cycle Process G2 DNA Damage Checkpoint Cellular Response To Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Meiotic Nuclear Division Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Response To Gamma Radiation Response To Abiotic Stimulus Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Cell Aging Reproduction DNA Replication Cellular Metabolic Process	Double-strand Break Repair Via Homologous Recombination Recombinational Repair Mitotic Recombination Double-strand Break Repair Meiotic Nuclear Division Meiotic Cell Cycle DNA Recombinase Assembly DNA Recombination Cell Cycle Meiosis I DNA-dependent DNA Replication Cellular Response To DNA Damage Stimulus Cell Cycle Process DNA Repair Reciprocal Meiotic Recombination DNA Replication Cellular Response To Stress DNA Duplex Unwinding DNA Geometric Change DNA Damage Response, Signal Transduction By P53 Class Mediator Chromosome Organization Reproduction DNA Metabolic Process Signal Transduction In Response To DNA Damage Nucleotide-excision Repair Organelle Organization 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Signal Transduction By P53 Class Mediator Positive Regulation Of Metabolic Process Positive Regulation Of DNA Ligation Dihydrobiopterin Metabolic Process Cellular Response To Camptothecin Response To Ionizing Radiation Response To Camptothecin Positive Regulation Of Extracellular Vesicular Exosome Assembly G1/S Transition Of Mitotic Cell Cycle Protein-DNA Complex Assembly Positive Regulation Of Cellular Metabolic Process Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Mitotic Cell Cycle Replication Fork Protection Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Homooligomerization Response To UV-C Substrate-dependent Cell Migration, Cell Extension Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Intracellular Signal Transduction
Tagcloud ?		185delag 5677insa adriamycin brca1 breaks camptothecin cip1 clones confer doubling du germ insbrca1 mdm obvious parental probands prostate slightly stably strand susceptibility taxol transfected transgenes vector virtue waf1 wtbrca1	abs beams bragg btg2 ccnb2 cdc25a cdc25c exo1 fen1 gadd45a gtse1 gy hle ifnb1 instantaneous karyotyping mdm4 mm2 passively prc1 protons pttg1 rpa1 siah1 tdr voxel xrcc2 xrcc3 xrcc6bp1
Tagcloud (Difference) ?		185delag 5677insa adriamycin brca1 breaks camptothecin cip1 clones confer doubling du germ insbrca1 mdm obvious parental probands prostate slightly stably strand susceptibility taxol transfected transgenes vector virtue waf1 wtbrca1	abs beams bragg btg2 ccnb2 cdc25a cdc25c exo1 fen1 gadd45a gtse1 gy hle ifnb1 instantaneous karyotyping mdm4 mm2 passively prc1 protons pttg1 rpa1 siah1 tdr voxel xrcc2 xrcc3 xrcc6bp1
Tagcloud (Intersection) ?