SRPK1 and HBS1L

Number of citations of the paper that reports this interaction (PMID 23602568)
8

Data Source:
BioGRID (enzymatic study)

		SRPK1	HBS1L
Gene Name		SRSF protein kinase 1	HBS1-like translational GTPase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Nuclear Matrix	Membrane Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding	Translation Elongation Factor Activity GTPase Activity GTP Binding
	Biological Process	MRNA Processing Protein Phosphorylation Chromosome Segregation RNA Splicing Viral Process Sperm Chromatin Condensation Intracellular Signal Transduction Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing	Translation Translational Elongation Signal Transduction
Pathways
Drugs
Diseases
GWAS			Beta thalassemia/hemoglobin E disease ( 20183929) HbA2 levels ( 23043469) Hematocrit ( 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863 19853236) Mean corpuscular hemoglobin ( 23263863 20139978 19862010) Mean corpuscular hemoglobin concentration ( 23263863 20139978) Mean corpuscular volume ( 23263863 20139978 19862010) Mean platelet volume ( 22423221) Other erythrocyte phenotypes ( 19862010) Platelet counts ( 22139419 20139978) Red blood cell count ( 20139978) Red blood cell traits ( 20927387 23222517) White blood cell count ( 20139978) White blood cell types ( 21738478)
Protein-Protein Interactions		174 interactors: ADPRH AHCYL1 ALKBH3 AMMECR1L APEX1 APP ARGLU1 ARHGAP12 ARHGAP26 ARL6IP4 ASAH1 ASXL1 AURKA AURKC C11orf52 C11orf63 C11orf87 C16orf78 C18orf25 C9orf72 CACNB1 CAMK2D CBX5 CDC42EP3 CDK7 CDKL3 CHEK2 CHERP CHUK CIAO1 CLIC5 CLK1 CLK4 CRHR1 CSAG1 DAW1 DDX47 DGCR8 DHX8 DHX9 DNAJC8 DUSP6 ECM1 EIF3M EPB41L4A EPHA3 ERBB2 ESRRG FAM124A FAM76B FERMT1 FGF12 FHL1 FKBP3 FLOT1 FLT1 GABARAP GABARAPL1 H2AFY HBS1L HIRIP3 HMGN3 HNRNPA1 IFIT5 IKBKG KCNAB1 KCNN2 KIAA1841 KPNA2 KPTN KRR1 LAMC1 LARP1 LBR LCE3D LIMK1 LINC00312 LUC7L LUC7L2 LUC7L3 MAGEB1 MAOB MAP1LC3A MAPK12 MAPK14 MAPKAPK5 MBNL3 MBP MRPL43 MRPS11 NCK2 NELFE NKAP NOL4L NOP16 NOVA1 NSMCE4A NSRP1 NUDT21 NXT2 OCEL1 ODF3L2 OR6B3 PAK4 PDGFRA PDPK1 PELI1 PELI2 PEX19 PFN1 PHF7 POLR2E PPIA PPIL1 PRM1 PRPF38A PTK2 RBM23 RBM39 RBM8A RBMS2 RIMS4 RNPS1 RPS6KB2 RSRC1 RSRC2 RSRP1 SAFB SCAF11 SEC23B SERPINB10 SETD3 SFMBT1 SLAIN2 SLC4A1AP SNRNP70 SPANXN4 SPATS2 SREK1 SRPK3 SRRM1 SRSF1 SRSF12 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 STAU1 STK26 SUDS3 TAF1B TFEB TNFRSF10C TOP2A TRA2B TRIM65 U2AF1 U2AF2 UBD UBE2E2 USP39 VANGL1 VDR WDR55 YPEL2 YTHDC1 YWHAG ZMYND11 ZNF444 ZNF514 ZRANB2 ZRSR2	5 interactors: APP PELO SRPK1 SRPK2 UBE2G2
Entrez ID		6732	10767
HPRD ID		15992	06582
Ensembl ID		ENSG00000096063	ENSG00000112339
Uniprot IDs		B4DS61 Q96SB4	D9YZV0 Q9Y450
PDB IDs		1WAK 1WBP 3BEG
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Processing RNA Splicing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process DNA-templated Transcription, Termination Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Termination Of RNA Polymerase II Transcription Heterocycle Metabolic Process Cellular Metabolic Process MRNA 3'-end Processing Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Nitrogen Compound Metabolic Process RNA 3'-end Processing Spliceosomal Complex Assembly RNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Export From Nucleus RNA Localization Nuclear Export MRNA Transport RNA Transport Nucleocytoplasmic Transport Nuclear Transport MRNA Splice Site Selection Ribonucleoprotein Complex Biogenesis Cellular Process Ribonucleoprotein Complex Assembly Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Gene Expression Protein Autophosphorylation Cytoplasmic Transport Regulation Of Alternative MRNA Splicing, Via Spliceosome Posttranscriptional Regulation Of Gene Expression Cellular Component Assembly Transcription, DNA-templated Metabolic Process Cellular Macromolecular Complex Assembly Regulation Of Metabolic Process RNA Biosynthetic Process Protein Phosphorylation Positive Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process	MRNA Metabolic Process Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Negative Regulation Of Viral Process Regulation Of MRNA Processing RNA Processing Regulation Of RNA Splicing Nuclear-transcribed MRNA Catabolic Process, Non-stop Decay Nuclear Speck Organization Nucleus Organization Innate Immune Response Synaptic Growth At Neuromuscular Junction Regulation Of Viral Process Collateral Sprouting In Absence Of Injury Nuclear-transcribed MRNA Catabolic Process, No-go Decay Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Positive Regulation Of Cell Cycle Immune Response RNA Metabolic Process Cellular Protein Modification Process Protein Phosphorylation Defense Response RNA Surveillance Neuron Remodeling Sperm Chromatin Condensation RNA Splicing Cellular Copper Ion Homeostasis Phosphorylation Copper Ion Homeostasis Suckling Behavior Cellular Protein Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Spermatid Nucleus Differentiation Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Immune System Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation
Tagcloud ?		70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk2 stringent sty u1 uniquely ww	10p14 2p16 3p24 6q23 8q24 eomes eomesodermin european gwas gwass haematopoiesis hl hla hodgkin identifies inherited insight intergenic localizes loci mapping maps meta myb perform rs3806624 rs7745098 susceptibility totalling
Tagcloud (Difference) ?		70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk2 stringent sty u1 uniquely ww	10p14 2p16 3p24 6q23 8q24 eomes eomesodermin european gwas gwass haematopoiesis hl hla hodgkin identifies inherited insight intergenic localizes loci mapping maps meta myb perform rs3806624 rs7745098 susceptibility totalling
Tagcloud (Intersection) ?