SREBF2 and OS9

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		SREBF2	OS9
Gene Name		sterol regulatory element binding transcription factor 2	osteosarcoma amplified 9, endoplasmic reticulum lectin
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane SREBP-SCAP-Insig Complex	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Lumen Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	C-8 Sterol Isomerase Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Protein Binding Protein C-terminus Binding Protein Dimerization Activity E-box Binding	Glycoprotein Binding Protease Binding Protein Binding Carbohydrate Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Lipid Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Cholesterol Storage Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Low-density Lipoprotein Particle Cellular Response To Laminar Fluid Shear Stress Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cholesterol Efflux Regulation Of Cholesterol Homeostasis	Protein Targeting Protein Retention In ER Lumen Protein Ubiquitination ER-associated Ubiquitin-dependent Protein Catabolic Process Response To Endoplasmic Reticulum Stress Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL3 GOLGB1 HDAC3 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LZTR1 MAPK1 MAPK3 MRPS6 NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SREBF1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX	16 interactors: ACVR1B CPNE6 CREB3 DCSTAMP EGLN1 EGLN3 EIF6 FOXM1 HIF1A MEP1B RBX1 SMAD2 SNRPD2 SREBF2 TRPV4 ZNF512B
Entrez ID		6721	10956
HPRD ID		02726	17804
Ensembl ID		ENSG00000198911	ENSG00000135506
Uniprot IDs		Q12772	B4E321 Q13438
PDB IDs		1UKL	3AIH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Signaling Viral Process RNA Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Protein Sumoylation Cell Communication Negative Regulation Of Biosynthetic Process Response To Organic Substance Regulation Of Metabolic Process Biosynthetic Process Cellular Response To Organic Substance Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Cellular Response To Stress Cell Surface Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Rhythmic Process Nitrogen Compound Metabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Protein Metabolic Process	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Oxygen Levels Cellular Response To Stress Oxygen Homeostasis Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Myeloid Cell Differentiation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Regulation Of Growth Nodal Signaling Pathway Regulation Of Cell Growth Positive Regulation Of Erythrocyte Differentiation 4-hydroxyproline Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Activin Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Peptidyl-proline Hydroxylation Protein Hydroxylation Activin Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Regulation Of Myeloid Cell Differentiation Heterocycle Metabolic Process Regulation Of Erythrocyte Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus In Utero Embryonic Development Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Growth Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Cellular Macromolecular Complex Assembly Cellular Response To Stimulus Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Cortical Microtubule Organization Osmosensory Signaling Pathway Neural Fold Elevation Formation Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		33a adipogenesis adipose beef bovine british cattle clustered conservation conserved continental coordinated coordinately crossbred determinant ebpalpha ep300 exonic intergenic intronic location micrornas mirna mirnas mirtron profiled qrt steers subcutaneous	branch c57y calnexin calreticulin cnx constrained erad folded folding futile glc1man7glcnac2 glycan glycans glycoproteins harbours improperly interconnected kifunensine lectins mannosidases mns4 mns5 oligosaccharide sel1l sort stabilized strubbelig subex thaliana
Tagcloud (Difference) ?		33a adipogenesis adipose beef bovine british cattle clustered conservation conserved continental coordinated coordinately crossbred determinant ebpalpha ep300 exonic intergenic intronic location micrornas mirna mirnas mirtron profiled qrt steers subcutaneous	branch c57y calnexin calreticulin cnx constrained erad folded folding futile glc1man7glcnac2 glycan glycans glycoproteins harbours improperly interconnected kifunensine lectins mannosidases mns4 mns5 oligosaccharide sel1l sort stabilized strubbelig subex thaliana
Tagcloud (Intersection) ?