SMARCB1 and KLF1

Number of citations of the paper that reports this interaction (PMID 11259590)
52

Data Source:
HPRD (in vitro)

		SMARCB1	KLF1
Gene Name		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Kruppel-like factor 1 (erythroid)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin XY Body Nucleus Nucleoplasm Nucleolus SWI/SNF Complex Protein Complex NpBAF Complex NBAF Complex	Nuclear Chromatin Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding P53 Binding Transcription Coactivator Activity Protein Binding Tat Protein Binding Nucleosomal DNA Binding	Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Blastocyst Hatching DNA Repair Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Negative Regulation Of Cell Proliferation DNA Integration Cell Differentiation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate ATP-dependent Chromatin Remodeling Positive Regulation By Host Of Viral Transcription Mitotic Cell Cycle Phase Transition Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	In Utero Embryonic Development Liver Development Chromatin Remodeling Transcription, DNA-templated Erythrocyte Differentiation Embryonic Hemopoiesis Erythrocyte Maturation Positive Regulation Of Transcription, DNA-templated Cellular Response To Peptide
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS		IgG glycosylation ( 23382691)
Protein-Protein Interactions		40 interactors: AKT1 APP BCL2L11 CALR CDX2 CEBPB DPF2 DPF3 GADD45G GATA1 KLF1 KMT2B KMT2C MAP1LC3B MAPK8IP2 MCPH1 MECP2 MYC NONO NR0B2 NR3C1 PDPK1 PPP1CC PPP1R15A PRMT5 RAN RB1 RELB RPS6KA5 SIN3B SMARCA4 SRC TACC2 TAF1D TP53 UBQLN4 XPO1 YEATS4 ZAK ZDHHC17	14 interactors: ARID1A CREBBP CSNK2A1 CSNK2A2 EP300 FLI1 HDAC1 PRKACA SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1
Entrez ID		6598	10661
HPRD ID		03364	07197
Ensembl ID		ENSG00000099956	ENSG00000105610
Uniprot IDs		G5E975 Q12824 Q9H836	Q13351
PDB IDs			2L2I
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Chromatin Organization Positive Regulation Of Metabolic Process Organelle Organization Transcription, DNA-templated Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Chromatin Modification Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Chromosome Organization Regulation Of Cellular Process RNA Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation System Development Regulation Of Signaling Developmental Process Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Negative Regulation Of Signal Transduction Regulation Of Phosphorylation Anatomical Structure Development Regulation Of Organelle Organization Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Phosphorus Metabolic Process	Nucleosome Disassembly Chromatin Modification ATP-dependent Chromatin Remodeling Chromatin Organization Chromatin Remodeling Chromosome Organization Nucleosome Organization Chromatin Assembly Or Disassembly Protein Complex Disassembly Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Positive Regulation Of Transcription, DNA-templated Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Developmental Process System Development Nervous System Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Interaction With Symbiont RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation By Host Of Viral Transcription Negative Regulation Of Cellular Metabolic Process Organelle Organization Regulation Of Viral Transcription RNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of Metabolic Process Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Regulation Of Viral Process
Tagcloud ?		abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating	acetylation active binds chromatin compromising contributing disappearance erythroid explore expressions facilitating forming gata generation globin interestingly k562 knockdown locus looping near occupancy stabilizing stably structure tal1 though transcribing unclear
Tagcloud (Difference) ?		abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating	acetylation active binds chromatin compromising contributing disappearance erythroid explore expressions facilitating forming gata generation globin interestingly k562 knockdown locus looping near occupancy stabilizing stably structure tal1 though transcribing unclear
Tagcloud (Intersection) ?