BMPR2 and BMP6

Number of citations of the paper that reports this interaction (PMID 11401330)
4

Data Source:
HPRD (in vivo)

		BMPR2	BMP6
Gene Name		bone morphogenetic protein receptor, type II (serine/threonine kinase)	bone morphogenetic protein 6
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Basal Plasma Membrane Cell Surface Apical Plasma Membrane Dendrite Neuronal Cell Body Spanning Component Of Plasma Membrane	Extracellular Space Cytoplasm Membrane-bounded Vesicle
	Molecular Function	Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Metal Ion Binding	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity Protein Heterodimerization Activity BMP Receptor Binding
	Biological Process	Mesoderm Formation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Transcription From RNA Polymerase II Promoter Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Brain Development Cellular Response To Starvation Anterior/posterior Pattern Specification Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Lung Blood Pressure Signal Transduction By Phosphorylation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Vasoconstriction Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Positive Regulation Of Axon Extension Involved In Axon Guidance Limb Development Endochondral Bone Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of DNA Biosynthetic Process	Skeletal System Development Osteoblast Differentiation Eye Development Kidney Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Type B Pancreatic Cell Development Cellular Iron Ion Homeostasis Inflammatory Response Immune Response Response To Iron Ion Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Activity Positive Regulation Of Bone Mineralization BMP Signaling Pathway Male Genitalia Development Response To Magnesium Ion Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Aldosterone Biosynthetic Process Response To Retinoic Acid Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Cartilage Development Response To Glucocorticoid SMAD Protein Signal Transduction Cellular Response To Mechanical Stimulus Positive Regulation Of DNA-dependent DNA Replication Positive Regulation Of Aldosterone Secretion
Pathways		Signaling by BMP
Drugs
Diseases
GWAS		Urate levels ( 23263486)	Height ( 20881960 23563607 18391951) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666)
Protein-Protein Interactions		49 interactors: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1	9 interactors: ACVR2A BMPER BMPR1A BMPR1B BMPR2 CHRDL2 NCOA3 SMAD5 SOSTDC1
Entrez ID		659	654
HPRD ID		02880	00211
Ensembl ID		ENSG00000204217	ENSG00000153162
Uniprot IDs		Q13873	B4DUF7 P22004 Q4VBA3
PDB IDs		2HLQ 3G2F	2QCW 2R52 2R53
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Ossification Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Cell Development Regulation Of Bone Mineralization Regulation Of MAPK Cascade Regulation Of Osteoblast Differentiation Regulation Of Phosphorylation Regulation Of Cell Differentiation Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorus Metabolic Process Growth Signal Transduction By Phosphorylation Regulation Of Signal Transduction Cartilage Development Regulation Of Ossification Positive Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Cartilage Development Regulation Of Growth Cell Surface Receptor Signaling Pathway Connective Tissue Development Positive Regulation Of Cartilage Development Phosphate-containing Compound Metabolic Process Peptidyl-threonine Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Response To Stimulus	Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Regulation Of BMP Signaling Pathway Tissue Development Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cartilage Development Regulation Of Ossification Pattern Specification Process Organ Development Regulation Of Bone Mineralization Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Skeletal System Development Sex Differentiation Tube Development Anatomical Structure Morphogenesis Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Cell Differentiation System Development Regulation Of Cell Differentiation Regulation Of Signal Transduction Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Multicellular Organismal Development Epithelium Development Regulation Of Signaling Anatomical Structure Development Mullerian Duct Regression Developmental Process Signal Transduction By Phosphorylation Developmental Process Involved In Reproduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Organ Morphogenesis Anatomical Structure Regression Mesoderm Development Embryo Development Cellular Response To BMP Stimulus Single Organism Reproductive Process Male Sex Differentiation Gastrulation Positive Regulation Of Signal Transduction Limb Development Reproductive Process Protein Phosphorylation
Tagcloud ?		apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap	anpep bmp2 bsp col il10 il6 itga6 ligament mcam mineralized mitf mmp2 msc mscs ocn orthodontic pdl predictability predictable premolar premolars prom1 regenerative rpl13a runt runx2 sialoprotein sox9 stemness
Tagcloud (Difference) ?		apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap	anpep bmp2 bsp col il10 il6 itga6 ligament mcam mineralized mitf mmp2 msc mscs ocn orthodontic pdl predictability predictable premolar premolars prom1 regenerative rpl13a runt runx2 sialoprotein sox9 stemness
Tagcloud (Intersection) ?