NCF1 and NCF4

Number of citations of the paper that reports this interaction (PMID 9083043)
16

Data Source:
BioGRID (pull down, two hybrid)

		NCF1	NCF4
Gene Name		neutrophil cytosolic factor 1	neutrophil cytosolic factor 4, 40kDa
Image
Gene Ontology Annotations	Cellular Component	Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Extrinsic Component Of Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body	Cytosol Endosome Membrane Membrane Phagolysosome NADPH Oxidase Complex
	Molecular Function	Protein Binding Electron Carrier Activity Superoxide-generating NADPH Oxidase Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding	Protein Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Protein Dimerization Activity
	Biological Process	Response To Yeast Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Respiratory Burst Involved In Defense Response Protein Targeting To Membrane Leukotriene Metabolic Process Superoxide Metabolic Process Apoptotic Process Inflammatory Response Cellular Defense Response Cell Proliferation Superoxide Anion Generation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Respiratory Burst Negative Regulation Of Smooth Muscle Contraction Vascular Endothelial Growth Factor Receptor Signaling Pathway Hydrogen Peroxide Biosynthetic Process Interaction With Host Oxidation-reduction Process Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Phagosome Maturation	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Catalytic Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Interaction With Host Oxidation-reduction Process Phagosome Maturation
Pathways		Signaling by VEGF Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation VEGFA-VEGFR2 Pathway Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System	Signaling by VEGF Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation VEGFA-VEGFR2 Pathway Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS			Atopic dermatitis ( 22197932)
Protein-Protein Interactions		23 interactors: ACTB CSNK2B CYBA FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF4 NOXA1 PRKCA PRKCB PRKCD PRKCZ PRKDC SRSF2 SYTL1 TRAF4 TRIM9	10 interactors: CORO1A CYBA CYBB MSN NCF1 NCF2 PRKCD PRKDC TXN XRCC6
Entrez ID		653361	4689
HPRD ID			03289
Ensembl ID		ENSG00000158517	ENSG00000100365
Uniprot IDs		P14598	Q15080
PDB IDs		1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP	1H6H 1OEY 1W6X 1W70 1Z9Q 2DYB
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Histone H3-T6 Phosphorylation Platelet Activation Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Peptidyl-threonine Phosphorylation Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Immune Response Apoptotic Signaling Pathway Apoptotic Process Regulation Of Catalytic Activity Programmed Cell Death Cell Activation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Phospholipase Activity Cell Death Regulation Of Protein Phosphorylation Death Blood Coagulation Regulation Of Cellular Protein Metabolic Process Hemostasis Cell Surface Receptor Signaling Pathway Regulation Of Phospholipase Activity Cellular Response To Carbohydrate Stimulus Organelle Organization Mitotic Cell Cycle Positive Regulation Of Lipase Activity Response To Interleukin-1 Innate Immune Response Regulation Of Glucose Transport Regulation Of Platelet Aggregation Regulation Of Protein Metabolic Process Muscle System Process Negative Regulation Of Glucose Transport Signaling Regulation Of Phosphorylation Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Protein Phosphorylation Peptidyl-serine Phosphorylation	Innate Immune Response Phagosome Maturation Respiratory Burst Superoxide Anion Generation Immune Response Immune System Process Defense Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Superoxide Metabolic Process Hydrogen Peroxide Biosynthetic Process Interaction With Host Reactive Oxygen Species Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Response To Stress Hydrogen Peroxide Metabolic Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Antigen Processing And Presentation Enzyme Linked Receptor Protein Signaling Pathway Response To Radiation Response To Ionizing Radiation Response To External Stimulus Double-strand Break Repair Via Nonhomologous End Joining Response To Abiotic Stimulus Organelle Organization V(D)J Recombination Cellular Response To Stimulus Regulation Of Ion Transport Positive Regulation Of Blood Pressure Homeostatic Process Signal Transduction Response To Gamma Radiation Regulation Of Cell Death Cellular Defense Response Cellular Response To Ionizing Radiation Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Communication Positive Regulation Of Phospholipid Scramblase Activity Smooth Muscle Hypertrophy Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Negative Regulation Of Glomerular Filtration By Angiotensin Telomere Maintenance Regulation Of Calcium Ion Transport Into Cytosol Response To Stimulus Positive Regulation Of Type I Interferon Production Cellular Response To Organic Substance
Tagcloud ?		anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vav3 vinorelbine	anion besides biopsies chl copy cyba cybb deleterious deletions downregulation exert hodgkin hybridisation lines lymphoma nadph ncf1 ncf2 oxidase phagocytic profiling progenitors proved quantify recurrent reed sternberg subsets superoxide
Tagcloud (Difference) ?		anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vav3 vinorelbine	anion besides biopsies chl copy cyba cybb deleterious deletions downregulation exert hodgkin hybridisation lines lymphoma nadph ncf2 oxidase phagocytic profiling progenitors proved quantify recurrent reed sternberg subsets superoxide
Tagcloud (Intersection) ?		ncf1