SLC6A4 and STX1A

Number of citations of the paper that reports this interaction (PMID 12175857)
12

Data Source:
HPRD (in vivo)

		SLC6A4	STX1A
Gene Name		solute carrier family 6 (neurotransmitter transporter), member 4	syntaxin 1A (brain)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Endomembrane System Neuron Projection Membrane Raft	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane SNARE Complex Actomyosin Neuron Projection Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex
	Molecular Function	Serotonin:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Serotonin Transmembrane Transporter Activity Myosin Binding Syntaxin-1 Binding Rab GTPase Binding Cocaine Binding Protein Homodimerization Activity Nitric-oxide Synthase Binding Actin Filament Binding	SNARE Binding Glycoprotein Binding SNAP Receptor Activity Protein Binding Myosin Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Protein Binding, Bridging Myosin Head/neck Binding ATP-dependent Protein Binding Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding
	Biological Process	Response To Hypoxia Serotonin Transport Response To Nutrient Memory Circadian Rhythm Response To Toxic Substance Positive Regulation Of Gene Expression Monoamine Transport Thalamus Development Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Estradiol Social Behavior Vasoconstriction Response To Drug Sperm Ejaculation Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Organ Growth Brain Morphogenesis Protein Oligomerization Protein Homooligomerization Serotonin Uptake Transmembrane Transport Cellular Response To Retinoic Acid Cellular Response To CGMP	Positive Regulation Of Neurotransmitter Secretion Energy Reserve Metabolic Process Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Pathogenesis Response To Gravity Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Calcium Ion-dependent Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Secretion By Cell Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Exocytosis Vesicle Docking Regulation Of Insulin Secretion Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways			Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Peptide hormone metabolism Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Insulin processing Serotonin Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Transmission across Chemical Synapses
Drugs		Fluvoxamine Phentermine Tramadol Citalopram Venlafaxine Atomoxetine Amitriptyline Protriptyline Methylphenidate Imipramine Fluoxetine Duloxetine Dextromethorphan Nortriptyline Amoxapine Fenfluramine Mazindol Trazodone Verapamil Paroxetine Trimipramine Minaprine Pseudoephedrine Cocaine Sertraline Sibutramine Chlorpheniramine Doxepin Nefazodone Desipramine Escitalopram Dexfenfluramine Clomipramine Ephedra MMDA 3,4-Methylenedioxymethamphetamine 4-Methoxyamphetamine Methamphetamine Zimelidine Amineptine Milnacipran Mianserin Tapentadol Desvenlafaxine Dexmethylphenidate Levomilnacipran
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CALR CANX STX1A YBX1	58 interactors: ABCC9 APBA1 ATP4B ATP6V1B1 CACNA1D CCSER2 CDK5 CFTR CPLX1 CSNK2A1 CSNK2A2 DAPK1 KCNB1 NAPA NAPB NSF PSMA3 RAB27A RIMS1 SCNN1A SCNN1B SCNN1G SDCBP SEPT2 SEPT5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SNAP23 SNAP25 SNAP29 SNPH STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TRDMT1 TXLNA TXLNB UNC13B VAMP1 VAMP2 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS18
Entrez ID		6532	6804
HPRD ID		01640	01721
Ensembl ID		ENSG00000108576	ENSG00000106089
Uniprot IDs		B2R7Y7 P31645	A8MZ54 Q16623 Q75ME0
PDB IDs
Enriched GO Terms of Interacting Partners?		Chaperone-mediated Protein Folding Protein N-linked Glycosylation Via Asparagine Synaptic Vesicle Transport Protein N-linked Glycosylation Peptide Antigen Assembly With MHC Class I Protein Complex Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Establishment Of Vesicle Localization Post-translational Protein Modification Vesicle Localization Antigen Processing And Presentation Of Peptide Antigen Sequestering Of Calcium Ion Regulation Of Cell Division CRD-mediated MRNA Stabilization Protein Transport Protein Folding Vesicle-mediated Transport Antigen Processing And Presentation Establishment Of Protein Localization Aging Positive Regulation Of Dendritic Cell Chemotaxis Establishment Of Organelle Localization Protein Glycosylation Macromolecule Glycosylation Glycosylation Receptor-mediated Endocytosis Glucocorticoid Receptor Signaling Pathway Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Regulation Of Vesicle-mediated Transport Glycoprotein Biosynthetic Process Sequestering Of Metal Ion Organelle Localization Synaptic Vesicle Fusion To Presynaptic Membrane Protein Maturation By Protein Folding Protein Localization Glycoprotein Metabolic Process Posttranscriptional Regulation Of Gene Expression Establishment Of Localization In Cell Response To Gravity Positive Regulation Of Neurotransmitter Secretion Secretion By Cell Cellular Response To Lithium Ion Negative Regulation Of Striated Muscle Cell Differentiation Synaptic Transmission Cellular Localization Glutamate Secretion Secretion Cortical Actin Cytoskeleton Organization Endocytosis MRNA Stabilization	Exocytosis Secretion By Cell Neurotransmitter Transport Secretion Regulation Of Exocytosis Regulation Of Neurotransmitter Levels Transport Vesicle-mediated Transport Regulation Of Secretion Neurotransmitter Secretion Synaptic Transmission Cell-cell Signaling Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Synaptic Vesicle Transport Synaptic Vesicle Exocytosis Cellular Localization Positive Regulation Of Exocytosis Regulation Of Cellular Localization Membrane Fusion Glutamate Secretion Establishment Of Vesicle Localization Vesicle Localization Ion Transport Vesicle Fusion Protein Transport Establishment Of Protein Localization Amino Acid Transport Vesicle Docking Organelle Fusion Membrane Docking Establishment Of Organelle Localization Membrane Organization Acid Secretion Vesicle Organization Positive Regulation Of Secretion Organelle Localization Protein Localization Monovalent Inorganic Cation Transport Anion Transport Dicarboxylic Acid Transport Regulated Secretory Pathway Metal Ion Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transport Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Sodium Ion Transport Organic Anion Transport
Tagcloud ?		adjective analyze anxiety authors bp check genotype genotypes homogeneous htt httlpr inventory list mao measuring menopausal mood nevertheless poland polymorphism possibility postmenopausal promoter prove region respondents slight trait vntr	colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Difference) ?		adjective analyze anxiety authors bp check genotype genotypes homogeneous htt httlpr inventory list mao measuring menopausal mood nevertheless poland polymorphism possibility postmenopausal promoter prove region respondents slight trait vntr	colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Intersection) ?