SHBG and ACTG2

Number of citations of the paper that reports this interaction (PMID 15862967)
1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SHBG	ACTG2
Gene Name		sex hormone-binding globulin	actin, gamma 2, smooth muscle, enteric
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome	Extracellular Space Cytosol Cytoskeleton Extracellular Vesicular Exosome Cell Periphery Blood Microparticle
	Molecular Function	Androgen Binding	ATP Binding
	Biological Process	Primary Spermatocyte Growth	Muscle Contraction
Pathways			Smooth Muscle Contraction
Drugs
Diseases
GWAS		Androgen levels ( 22936694) Protein quantitative trait loci ( 18464913) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597)
Protein-Protein Interactions		62 interactors: A2M ACPP ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5A1 AZGP1 C9orf24 CD177 CECR5 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A	3 interactors: EMD MLH1 SHBG
Entrez ID		6462	72
HPRD ID		01646	00016
Ensembl ID		ENSG00000129214	ENSG00000163017
Uniprot IDs		B0FWH2 B4DYU0 I3L1J1 I3L2X4 P04278	P63267
PDB IDs		1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW
Enriched GO Terms of Interacting Partners?		Platelet Activation Extracellular Matrix Disassembly Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cellular Response To Zinc Ion Endocytosis Vesicle-mediated Transport Response To Wounding Transport Endosomal Transport Cell Activation Response To Zinc Ion Cell Projection Organization Immune System Process MRNA Transcription From RNA Polymerase II Promoter Glucose Metabolic Process MRNA Transcription Neuron Projection Development Movement Of Cell Or Subcellular Component Cellular Response To Cadmium Ion Regulation Of Water Loss Via Skin Formation Of Translation Preinitiation Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cell Morphogenesis Involved In Differentiation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Receptor-mediated Endocytosis Hexose Metabolic Process Neuron Development Extracellular Matrix Organization Viral Process Cytoplasmic Sequestering Of Protein Regulation Of Defense Response To Virus By Virus Extracellular Structure Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Axon Development Antigen Processing And Presentation Of Peptide Antigen Locomotion Negative Regulation Of Growth Monosaccharide Metabolic Process Sperm Entry Negative Regulation Of T Cell Migration Contractile Actin Filament Bundle Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Positive Regulation Of Late Endosome To Lysosome Transport Sorbitol Catabolic Process L-xylitol Metabolic Process L-xylitol Catabolic Process Fructose Biosynthetic Process	Meiotic Spindle Midzone Assembly Primary Spermatocyte Growth Meiotic Metaphase I Plate Congression Negative Regulation Of Mitotic Recombination Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Spindle Midzone Assembly Mitotic Nuclear Envelope Reassembly Negative Regulation Of Catenin Import Into Nucleus Spermatogenesis Male Gamete Generation Resolution Of Meiotic Recombination Intermediates Nuclear Envelope Reassembly Somatic Hypermutation Of Immunoglobulin Genes Positive Regulation Of Protein Export From Nucleus Somatic Diversification Of Immune Receptors Via Somatic Mutation Gamete Generation Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination Developmental Process Involved In Reproduction Regulation Of Catenin Import Into Nucleus Nuclear-transcribed MRNA Poly(A) Tail Shortening Cell Differentiation Isotype Switching Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Metaphase Plate Congression Regulation Of Protein Export From Nucleus Somatic Recombination Of Immunoglobulin Gene Segments Mitotic Nuclear Envelope Disassembly Negative Regulation Of Fibroblast Proliferation Somatic Diversification Of Immunoglobulins Nuclear Envelope Disassembly Establishment Of Chromosome Localization Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Reciprocal Meiotic Recombination Reproduction Cell Cycle Process B Cell Activation Involved In Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Synapsis Mismatch Repair Homologous Chromosome Segregation Single Organism Reproductive Process Male Meiosis Skeletal Muscle Cell Differentiation Immunoglobulin Production Regulation Of DNA Recombination
Tagcloud ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm grm1 grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shr symbol wtc zi	adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom ezr fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Difference) ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm grm1 grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shr symbol wtc zi	adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom ezr fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Intersection) ?