ITSN1 and SYNJ1

Number of citations of the paper that reports this interaction (PMID 10373452)
37

Data Source:
HPRD (in vitro)

		ITSN1	SYNJ1
Gene Name		intersectin 1 (SH3 domain protein)	synaptojanin 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Coated Pit Lamellipodium Cell Junction Endocytic Vesicle Neuron Projection Synapse	Cytosol Membrane Coat
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Kinase Activator Activity Protein Complex Scaffold Proline-rich Region Binding	Nucleotide Binding RNA Binding Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity
	Biological Process	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Neurotransmitter Transport Synaptic Vesicle Priming Synaptic Vesicle Uncoating Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Regulation Of Synaptic Vesicle Membrane Organization Positive Regulation Of Synaptic Vesicle Uncoating
Pathways		Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHB-mediated forward signaling GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Synthesis of IP2, IP, and Ins in the cytosol Metabolism of lipids and lipoproteins Phospholipid metabolism Inositol phosphate metabolism PI Metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		82 interactors: AGFG1 AGFG2 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHSD2 FNBP1 FNBP4 GAREML GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 RAB11FIP2 RAB5A RABEP1 RAI14 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SH3GL2 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 WASL WBP11 ZAK ZFPM2	23 interactors: AMPH AP2A1 AP2M1 BIN1 CDK5 CLTA CLTC EPHB2 EPS15 FNBP4 GRB2 ITSN1 PACSIN1 PACSIN2 PACSIN3 PPP3CA SH3BP1 SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SH3KBP1 SORBS2
Entrez ID		6453	8867
HPRD ID		03898	09182
Ensembl ID		ENSG00000205726	ENSG00000159082
Uniprot IDs		A7XZY7 F8W7U0 Q15811 Q6PD56	B9EGN3 C9JFZ1 J3KPK1 J3KQV8 O43426 Q05CZ1
PDB IDs		1KI1 2KGR 2KHN 3FIA 3QBV 4IIM	1W80 2DNR 2VJ0
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Endocytosis Vesicle Organization Cellular Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Signaling Synaptic Transmission Regulation Of Cellular Component Organization Establishment Of Organelle Localization Cell Communication Regulation Of Signaling Organelle Organization Protein Localization Cell Differentiation Synaptic Vesicle Transport Cell-cell Signaling Membrane Budding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Localization Regulation Of ERBB Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Establishment Of Vesicle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vesicle Localization Transport Cell Morphogenesis Involved In Neuron Differentiation Axon Guidance Generation Of Neurons Cell Morphogenesis Involved In Differentiation Membrane Organization Cell Projection Morphogenesis Cell Part Morphogenesis Establishment Of Protein Localization Cell Projection Organization Synaptic Vesicle Recycling Axonogenesis Cellular Protein Complex Assembly Neurogenesis Regulation Of Catalytic Activity Regulation Of Signal Transduction Intracellular Transport Cell Morphogenesis	Endocytosis Vesicle-mediated Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Transport Neuron Projection Morphogenesis Cell-cell Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Axonogenesis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Neuron Projection Development Regulation Of Cellular Component Organization Axon Development Cell Projection Organization Membrane Organization Synaptic Transmission Cell Morphogenesis Involved In Neuron Differentiation Neurotrophin TRK Receptor Signaling Pathway Chemotaxis Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Synaptic Vesicle Transport Locomotion Neuron Development Membrane Tubulation Cell Morphogenesis Involved In Differentiation Nervous System Development Cellular Localization Movement Of Cell Or Subcellular Component Neuron Differentiation Establishment Of Localization In Cell Generation Of Neurons Regulation Of Endocytosis Neurogenesis Regulation Of Vesicle-mediated Transport Establishment Of Vesicle Localization Vesicle Localization
Tagcloud ?		cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3	aberrations abundance amplified block copy druggable encodes endocytic gain gains inositol invadopodia knocking lamellipodia libraries member microrna migration neural phosphatase promoted recycling search shorter similarly synaptojanin synj2 targetable xenografts
Tagcloud (Difference) ?		cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3	aberrations abundance amplified block copy druggable encodes endocytic gain gains inositol invadopodia knocking lamellipodia libraries member microrna migration neural phosphatase promoted recycling search shorter similarly synaptojanin synj2 targetable xenografts
Tagcloud (Intersection) ?