SRSF2 and U2AF1

Number of citations of the paper that reports this interaction (PMID 8261509)
277

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (in vivo)

		SRSF2	U2AF1
Gene Name		serine/arginine-rich splicing factor 2	U2 small nuclear RNA auxiliary factor 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm PML Body Nuclear Speck Extracellular Vesicular Exosome	Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function	Nucleotide Binding Transcription Corepressor Activity Protein Binding Poly(A) RNA Binding	Nucleotide Binding Protein Binding Poly(A) RNA Binding Metal Ion Binding RS Domain Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Processing MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing Negative Regulation Of Nucleic Acid-templated Transcription	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Processing MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing	mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ADAP1 BARD1 CCNL1 CCNL2 CDK12 CDK6 CEP72 CIR1 CSNK2A1 FUS GEMIN2 GOLGA2 KRT31 KRT40 LIG4 LZTS2 NCF1 PRCC SCAF11 SNRNP70 SREK1 SRSF1 SRSF11 SRSF3 SRSF4 TCF4 TRA2B TRIM27 U2AF1 UBQLN4 YTHDC1 ZRANB2 ZRSR2	38 interactors: AP2B1 CHERP CIR1 CLK2 DHX38 EPB41 FRA10AC1 HINFP HNRNPK IL7R JMJD6 MAP1B MFAP1 NDN NKAP NXF1 PABPC1 PRPF19 PRPF38A PRPF4 PRPF40A RBM10 RNPS1 RP9 SF3A3 SF3B2 SNRPD1 SRPK1 SRPK2 SRSF1 SRSF2 SUV39H1 TOE1 U2AF2 VEGFA ZCCHC10 ZRANB2 ZRSR2
Entrez ID		6427	7307
HPRD ID		02888	01871
Ensembl ID		ENSG00000161547	ENSG00000160201
Uniprot IDs		Q01130 Q53FN0	Q01081 Q7Z780
PDB IDs		2KN4 2LEA 2LEB 2LEC	1JMT
Enriched GO Terms of Interacting Partners?		RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Termination Of RNA Polymerase II Transcription Nitrogen Compound Metabolic Process Nuclear Export Spliceosomal Complex Assembly MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus Nucleocytoplasmic Transport Nuclear Transport MRNA 3'-end Processing Regulation Of MRNA Processing RNA 3'-end Processing MRNA Transport RNA Transport Cellular Macromolecular Complex Assembly RNA Localization Regulation Of MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Assembly Cell Cycle Regulation Of RNA Splicing Regulation Of Cell Cycle Cytoplasmic Transport Cellular Metabolic Process Mitotic Cell Cycle Cell Cycle Process Ribonucleoprotein Complex Biogenesis Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Intracellular Transport RNA Biosynthetic Process Mitotic Cell Cycle Process Negative Regulation Of Cell Cycle Cellular Component Assembly Positive Regulation Of MRNA Splicing, Via Spliceosome DNA Strand Elongation Involved In DNA Replication Cellular Localization DNA Strand Elongation Regulation Of Protein Export From Nucleus	RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Splicing Cellular Nitrogen Compound Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nitrogen Compound Metabolic Process Spliceosomal Complex Assembly MRNA Export From Nucleus RNA Export From Nucleus MRNA 3'-end Processing Termination Of RNA Polymerase II Transcription RNA 3'-end Processing MRNA Transport Nuclear Export RNA Transport RNA Localization DNA-templated Transcription, Termination Ribonucleoprotein Complex Assembly Ribonucleoprotein Complex Biogenesis Nucleocytoplasmic Transport Nuclear Transport Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Process Regulation Of Gene Expression Cytoplasmic Transport Transcription, DNA-templated RNA Biosynthetic Process Viral Process Transcription From RNA Polymerase II Promoter Intracellular Transport Cellular Macromolecular Complex Assembly Negative Regulation Of MRNA Splicing, Via Spliceosome Establishment Of Localization In Cell Cellular Localization Negative Regulation Of RNA Splicing Negative Regulation Of Gene Expression Positive Regulation Of Viral Genome Replication Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		asxl1 biologic clonal cmml created cytopenias dependence discern dysplasia entity extramedullary extrapolation focuses granulocyte hematologic identifies landscape macrophage makes malignancy monocytosis myelomonocytic ontology propensity scientific speculative supporting tools troublesome	allelic arisen biallelic biallellic chimeric chimerism compromised developmentally es establishes fetal fetuses h19 igf2 igf2r imprinted interstitial mandible manipulation maternal maternally paternally persist persisted polyhydramnios preimplantation repression rs1 totipotency
Tagcloud (Difference) ?		asxl1 biologic clonal cmml created cytopenias dependence discern dysplasia entity extramedullary extrapolation focuses granulocyte hematologic identifies landscape macrophage makes malignancy monocytosis myelomonocytic ontology propensity scientific speculative supporting tools troublesome	allelic arisen biallelic biallellic chimeric chimerism compromised developmentally es establishes fetal fetuses h19 igf2 igf2r imprinted interstitial mandible manipulation maternal maternally paternally persist persisted polyhydramnios preimplantation repression rs1 totipotency
Tagcloud (Intersection) ?