CXCL12 and CD4

Number of citations of the paper that reports this interaction (PMID 10600606)
4

Data Source:
HPRD (in vitro)

		CXCL12	CD4
Gene Name		chemokine (C-X-C motif) ligand 12	CD4 molecule
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane Extracellular Vesicular Exosome	Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Membrane Raft
	Molecular Function	Receptor Binding Chemokine Activity Growth Factor Activity Chemokine Receptor Binding CXCR Chemokine Receptor Binding	Glycoprotein Binding Receptor Activity Transmembrane Signaling Receptor Activity Extracellular Matrix Structural Constituent Protein Binding Zinc Ion Binding Coreceptor Activity Enzyme Binding Protein Kinase Binding MHC Class II Protein Binding Protein Homodimerization Activity
	Biological Process	Patterning Of Blood Vessels Response To Hypoxia Ameboidal-type Cell Migration Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Cellular Calcium Ion Homeostasis Chemotaxis Immune Response Cell Adhesion Signal Transduction G-protein Coupled Receptor Signaling Pathway Germ Cell Development Blood Circulation Motor Neuron Axon Guidance Regulation Of Actin Polymerization Or Depolymerization Adult Locomotory Behavior Germ Cell Migration Response To Radiation Response To Heat Response To Mechanical Stimulus Response To Virus Telencephalon Cell Migration Organ Regeneration Positive Regulation Of Dopamine Secretion T Cell Proliferation Response To Peptide Hormone Positive Regulation Of Cell Adhesion Positive Regulation Of Axon Extension Involved In Axon Guidance Induction Of Positive Chemotaxis Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Calcium Ion Import Positive Regulation Of Myoblast Fusion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Leukocyte Tethering Or Rolling Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of T Cell Migration	Cytokine Production Induction By Virus Of Host Cell-cell Fusion Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Viral Process T Cell Differentiation Entry Into Host Cell T Cell Costimulation Maintenance Of Protein Location In Cell T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Protein Palmitoleylation Positive Regulation Of Protein Kinase Activity Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Regulation Of T Cell Activation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Signaling by ERBB4 GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Nuclear signaling by ERBB4 Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events	Vpu mediated degradation of CD4 Downstream TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Costimulation by the CD28 family Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Early Phase of HIV Life Cycle HIV Life Cycle TCR signaling Alpha-defensins PD-1 signaling Defensins Phosphorylation of CD3 and TCR zeta chains Nef Mediated CD4 Down-regulation Binding and entry of HIV virion Innate Immune System Adaptive Immune System
Drugs		Tinzaparin
Diseases
GWAS		Coronary heart disease ( 17634449 21378990) Myocardial infarction (early onset) ( 19198609) Schizophrenia ( 23212062)	Response to Vitamin E supplementation ( 22437554)
Protein-Protein Interactions		10 interactors: CD4 CTSG CXCR4 DAZAP2 DPP4 ELANE FN1 MMP2 PF4 VCAN	38 interactors: ABCB1 ADRB2 CCR5 CD2 CD28 CD38 CD44 CD5 CD53 CD82 CTSD CXCL12 CXCR4 DPP4 FCGR3A HLA-DPA1 HLA-DQA2 HLA-DQB1 IL16 IL2RA INPPL1 KCNAB2 LAT LCK LGALS1 MAPK14 MARCH4 PI4KA PIK3R1 PIP PTPRC SELL SIVA1 SPG21 TFRC TNFRSF10A UBL7 UNC119
Entrez ID		6387	920
HPRD ID		02904	01740
Ensembl ID		ENSG00000107562	ENSG00000010610
Uniprot IDs		H7BYN8 P48061	B0AZV7 B4DT49 P01730
PDB IDs		1A15 1QG7 1SDF 1VMC 2J7Z 2K01 2K03 2K04 2K05 2KEC 2KED 2KEE 2KOL 2NWG 2SDF 3GV3 3HP3 4LMQ	1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1OPN 1OPT 1OPW 1Q68 1RZJ 1RZK 1WBR 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2KLU 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 2NY5 2NY6 2QAD 3B71 3CD4 3JWD 3JWO 3LQA 3O2D 3S4S 3S5L 3T0E 4JM2
Enriched GO Terms of Interacting Partners?		Locomotion Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Movement Of Cell Or Subcellular Component Cell Migration Positive Regulation Of Immune System Process Cell Motility Leukocyte Migration Response To Stress Immune System Process Regulation Of Immune System Process Cell Activation Defense Response Response To Other Organism Killing By Host Of Symbiont Cells Response To Biotic Stimulus Inflammatory Response Response To External Stimulus Regulation Of Chemotaxis Response To Bacterium Neutrophil Mediated Immunity Cell Adhesion Killing Of Cells Of Other Organism Regulation Of Behavior Defense Response To Bacterium Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Positive Regulation Of Immune Response Interaction With Symbiont Leukocyte Mediated Cytotoxicity Endodermal Cell Differentiation Response To Fungus Entry Into Host Cell T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Positive Regulation Of Intracellular Signal Transduction Response To Hypoxia Response To Lipopolysaccharide Leukocyte Cell-cell Adhesion Endoderm Formation Regulation Of Immune Response Cardiovascular System Development Homotypic Cell-cell Adhesion Angiogenesis Response To Molecule Of Bacterial Origin Chemokine-mediated Signaling Pathway Collagen Catabolic Process	Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Regulation Of Immune System Process Regulation Of T Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Activation Positive Regulation Of Cell-cell Adhesion T Cell Costimulation Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Stimulus Immune Response-regulating Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune Response Signaling Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Lymphocyte Activation Leukocyte Aggregation Cellular Response To Stimulus Apoptotic Process Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Programmed Cell Death Response To Stress Leukocyte Migration Leukocyte Activation Cell Death Death Cell Activation Defense Response Homeostatic Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Locomotion Cell Migration Cell Motility Single Organismal Cell-cell Adhesion Cellular Chemical Homeostasis
Tagcloud ?		adam23 adenomatous apc bc bcs cumulative detecting disintegrin hypermethylation informative invasiveness lnms maintaining manifested metalloprotease methylated methylation methylations pl polyposis pts pyrosequencing quantification quantify rassf1a software spectrums spss utility	allergen asthmatics box caat cd18 chemotactic coactivator complexity concert consists dyad exons ga gabp gabpalpha harbor inducible introns lymphocytes mast motifs posttranslational pro processed remote share supplementing symmetry tata tightly
Tagcloud (Difference) ?		adam23 adenomatous apc bc bcs cumulative detecting disintegrin hypermethylation informative invasiveness lnms maintaining manifested metalloprotease methylated methylation methylations pl polyposis pts pyrosequencing quantification quantify rassf1a software spectrums spss utility	allergen asthmatics box caat cd18 chemotactic coactivator complexity concert consists dyad exons ga gabp gabpalpha harbor inducible introns lymphocytes mast motifs posttranslational pro processed remote share supplementing symmetry tata tightly
Tagcloud (Intersection) ?