RPS3A and SOD2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RPS3A	SOD2
Gene Name		ribosomal protein S3A	superoxide dismutase 2, mitochondrial
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Focal Adhesion Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Nucleoid Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding	DNA Binding Superoxide Dismutase Activity Oxygen Binding Manganese Ion Binding Identical Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cell Differentiation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process	Response To Reactive Oxygen Species Response To Superoxide Age-dependent Response To Reactive Oxygen Species Response To Hypoxia Release Of Cytochrome C From Mitochondria Liver Development Detection Of Oxygen Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Transcription From RNA Polymerase II Promoter Glutathione Metabolic Process Superoxide Metabolic Process Heart Development Locomotory Behavior Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Cold Post-embryonic Development Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Response To Gamma Radiation Response To Activity Removal Of Superoxide Radicals Respiratory Electron Transport Chain Hemopoiesis Oxygen Homeostasis Response To Lipopolysaccharide Response To L-ascorbic Acid Response To Silicon Dioxide Response To Isolation Stress Response To Immobilization Stress Response To Drug Response To Hydrogen Peroxide Superoxide Anion Generation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Response To Cadmium Ion Negative Regulation Of Fibroblast Proliferation Neuron Development Response To Axon Injury Erythrophore Differentiation Hydrogen Peroxide Biosynthetic Process Regulation Of Catalytic Activity Protein Homotetramerization Response To Electrical Stimulus Regulation Of Mitochondrial Membrane Potential Iron Ion Homeostasis Response To Hyperoxia Response To Magnetism Cellular Response To Ethanol Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS		HDL cholesterol ( 20686565)	Age-related macular degeneration (GA) ( 22705344)
Protein-Protein Interactions		15 interactors: ATF7IP C11orf49 CCDC50 CHN1 DDIT3 EDEM2 FANCC HGS HSP90AA1 NEDD4 PARP1 SAP18 SOD2 TOE1 VDAC2	8 interactors: APP CYP4F12 GET4 HDHD2 KIAA1549 NOL12 RAB4A RPS3A
Entrez ID		6189	6648
HPRD ID		01606	00938
Ensembl ID		ENSG00000145425	ENSG00000112096
Uniprot IDs		B7Z3M5 P61247	P04179
PDB IDs		3J3A	1AP5 1AP6 1EM1 1JA8 1LUV 1LUW 1MSD 1N0J 1N0N 1PL4 1PM9 1QNM 1SZX 1VAR 1XDC 1XIL 1ZSP 1ZTE 1ZUQ 2ADP 2ADQ 2GDS 2P4K 2QKA 2QKC 3C3S 3C3T
Enriched GO Terms of Interacting Partners?		Cellular Response To Superoxide Response To Superoxide Response To Oxygen Radical Cellular Response To Reactive Oxygen Species Protein Targeting To Lysosome Reactive Oxygen Species Metabolic Process Protein Localization To Lysosome Removal Of Superoxide Radicals Response To Unfolded Protein Cellular Response To Stress Positive Regulation Of Metabolic Process Protein Targeting To Vacuole Response To Inorganic Substance Establishment Of Protein Localization To Vacuole Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Negative Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Signal Transduction Negative Regulation Of RNA Biosynthetic Process Superoxide Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Lysosomal Transport Regulation Of Signaling Negative Regulation Of Gene Expression Cytoplasmic Transport Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Stress Negative Regulation Of Determination Of Dorsal Identity Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure Erythrophore Differentiation Age-dependent Response To Reactive Oxygen Species Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Response To DNA Damage Stimulus Establishment Of Protein Localization To Organelle Vacuolar Transport Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Neuron Development	Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Pressure Natriuresis Vitamin K Biosynthetic Process Membrane Organization Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Cellular Localization Establishment Of Protein Localization To Membrane Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Vitamin K Metabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Long-chain Fatty Acid Catabolic Process Protein Insertion Into ER Membrane Neuron Remodeling Cellular Protein Localization Protein Localization To Membrane
Tagcloud ?			arbitrary biogenesis catalase centrally damages dihydroethidium dw femoral hypoperfusion iliac ligatures methoxyisobutylisonitrile mibi mimicking minute mmol muscles myopathic paramagnetic pgc proliferator respiration rounded scintigraphic scintigraphies submitted swiss vmax wider
Tagcloud (Difference) ?			arbitrary biogenesis catalase centrally damages dihydroethidium dw femoral hypoperfusion iliac ligatures methoxyisobutylisonitrile mibi mimicking minute mmol muscles myopathic paramagnetic pgc proliferator respiration rounded scintigraphic scintigraphies submitted swiss vmax wider
Tagcloud (Intersection) ?