BCL3 and N4BP2

Number of citations of the paper that reports this interaction (PMID 12730195)
14

Data Source:
HPRD (in vitro, in vivo)

		BCL3	N4BP2
Gene Name		B-cell CLL/lymphoma 3	NEDD4 binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Bcl3-Bcl10 Complex Bcl3/NF-kappaB2 Complex Protein Complex Intercellular Bridge Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Binding, Bridging	Endonuclease Activity Protein Binding ATP Binding ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity
	Biological Process	Protein Import Into Nucleus, Translocation Follicular Dendritic Cell Differentiation Marginal Zone B Cell Differentiation Humoral Immune Response Mediated By Circulating Immunoglobulin Germinal Center Formation Transcription, DNA-templated Cellular Response To DNA Damage Stimulus I-kappaB Kinase/NF-kappaB Signaling Response To Virus Response To UV-C Antimicrobial Humoral Response Extracellular Matrix Organization DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Interferon-gamma Production T-helper 1 Type Immune Response Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Defense Response To Bacterium Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Defense Response To Protozoan Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process T-helper 2 Cell Differentiation Positive Regulation Of Interleukin-10 Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Translation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Regulation Of DNA Binding Maintenance Of Protein Location In Nucleus	Phosphorylation Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 23565137)
Protein-Protein Interactions		31 interactors: BARD1 COPS5 CREBBP CTBP1 CTBP2 CTNNB1 EP300 FOS FYN GSK3A GSK3B GTF2A1 GTF2B HDAC1 HDAC3 HDAC6 JUN KAT5 MAPK3 MAPRE1 N4BP2 NCOA1 NCOA6 NFKB1 NFKB2 PIR RAB9A RUVBL2 RXRA SHC1 TBP	5 interactors: BCL3 CREBBP EP300 NEDD4 TOLLIP
Entrez ID		602	55728
HPRD ID		00179	11382
Ensembl ID		ENSG00000069399	ENSG00000078177
Uniprot IDs		P20749	Q86UW6
PDB IDs		1K1A 1K1B	2D9I 2VKC 3BHB 3FAU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Viral Process Response To Growth Factor Response To Organic Substance Cellular Response To Organic Substance Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Hormone Cellular Response To Hormone Stimulus Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway DNA-templated Transcription, Initiation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Histone Modification Cellular Response To Stress Fc Receptor Signaling Pathway Regulation Of Protein Metabolic Process	N-terminal Peptidyl-lysine Acetylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Immune Response N-terminal Protein Amino Acid Acetylation Immune System Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cytokine Production Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Gene Expression Defense Response Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Response To Stress Cellular Response To Heat Cellular Response To Stress Leukocyte Activation Protein Localization To Organelle Positive Regulation Of Type I Interferon Production Regulation Of Cytokine Production Viral Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Decreased Oxygen Levels Regulation Of Type I Interferon Production Histone H2B Acetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Response To Oxygen Levels Response To Heat Histone Acetylation Cell Activation Signal Transduction By P53 Class Mediator Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Cellular Metabolic Process Protein Acetylation Response To UV Negative Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	atta bcl blocks china e3l exons glu118lys gttg haplotype intron6 introns loc123 locus met171val nasopharyngeal nearby nedd4 npc oncoprotein overexpressed paired position rs17511668 rs794001 snp1 snp2 snps southern sporadic
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	atta bcl blocks china e3l exons glu118lys gttg haplotype intron6 introns loc123 locus met171val nasopharyngeal nearby nedd4 npc oncoprotein overexpressed paired position rs17511668 rs794001 snp1 snp2 snps southern sporadic
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