RGS12 and PLCB3

Number of citations of the paper that reports this interaction (PMID 9651375)
33

Data Source:
HPRD (in vitro)

		RGS12	PLCB3
Gene Name		regulator of G-protein signaling 12	phospholipase C, beta 3 (phosphatidylinositol-specific)
Image
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleus Nucleolus Cytoplasm Plasma Membrane Nuclear Matrix	Nucleoplasm Cytosol Membrane Protein Complex
	Molecular Function	Receptor Signaling Protein Activity GTPase Activator Activity GTPase Regulator Activity	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Signal Transducer Activity Calcium Ion Binding Calmodulin Binding
	Biological Process	Transcription, DNA-templated Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of Catalytic Activity	Regulation Of Systemic Arterial Blood Pressure Synaptic Transmission Lipid Catabolic Process Intracellular Signal Transduction Inositol Phosphate Metabolic Process Small Molecule Metabolic Process
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events	G alpha (q) signalling events Signaling by GPCR Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Integration of energy metabolism G beta:gamma signalling through PLC beta Signaling by Wnt Synthesis of IP3 and IP4 in the cytosol Gastrin-CREB signalling pathway via PKC and MAPK Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell PLC beta mediated events G-protein beta:gamma signalling Opioid Signalling Regulation of insulin secretion G-protein mediated events Activation of Kainate Receptors upon glutamate binding Inositol phosphate metabolism beta-catenin independent WNT signaling Presynaptic function of Kainate receptors G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Ca2+ pathway Free fatty acids regulate insulin secretion Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ARAF CACNA1B CXCR2 EEF1A1 GNAI1 GNAI2 GNAI3 GRM2 GRM5 HRAS MAP2K2 NPY2R PLCB1 PLCB3 YWHAG	13 interactors: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 PARD3 PARD6A PRKG1 PRKG2 RGS12 SLC9A3R2 TRPC3 TRPM7
Entrez ID		6002	5331
HPRD ID		03943	02577
Ensembl ID		ENSG00000159788	ENSG00000149782
Uniprot IDs		O14924	Q01970
PDB IDs		2EBZ 2KV8	3OHM 4GNK
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Synaptic Transmission Signaling G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Communication Response To Stimulus G-protein Coupled Receptor Signaling Pathway Cellular Response To Stimulus Signal Transduction Regulation Of CAMP Biosynthetic Process Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of CAMP Metabolic Process Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Adenylate Cyclase Activity Regulation Of Phosphorylation Glutamate Receptor Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Synaptic Transmission, Glutamatergic Activation Of MAPKK Activity Regulation Of Cyclase Activity Activation Of Protein Kinase Activity Behavior Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Catalytic Activity Regulation Of Cellular Process G-protein Coupled Acetylcholine Receptor Signaling Pathway Regulation Of Locomotion Cell Activation G-protein Coupled Glutamate Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Cell Cycle Blood Coagulation	Regulation Of Calcium Ion Transport Protein Autophosphorylation Regulation Of Skeletal Muscle Adaptation Wound Healing Calcium Ion Transport Response To Wounding Signal Transduction Negative Regulation Of Peptidyl-threonine Phosphorylation Blood Coagulation Hemostasis Signaling Cell Communication Nitric Oxide Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cellular Response To Heat Reactive Nitrogen Species Metabolic Process Regulation Of Nitric-oxide Synthase Activity Regulation Of Body Fluid Levels Phosphorylation Regulation Of Ion Transport Tight Junction Assembly Cellular Response To Stimulus Protein Phosphorylation System Development Inhibitory G-protein Coupled Receptor Phosphorylation Cellular Response To Heat Response To Metal Ion Nervous System Development Apical Junction Assembly Regulation Of Oxidoreductase Activity Metal Ion Transport Regulation Of Calcium Ion Transport Into Cytosol Response To Stress Pharynx Development Activation Of Meiosis Involved In Egg Activation Positive Regulation Of Calcium Ion Transport Multicellular Organismal Development Phototransduction Response To Organic Substance Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Anatomical Structure Development Detection Of Light Stimulus Response To Heat Reactive Oxygen Species Metabolic Process Regulation Of Cellular Process Response To Calcium Ion Peptidyl-serine Phosphorylation Cell-cell Junction Assembly Response To Inorganic Substance Interferon-gamma-mediated Signaling Pathway
Tagcloud ?		alveolar avenues bones combat craniofacial destruction forearm isoflavone menopausal microbe mkp multipotent nfatc1 oscillation oscillations osteoclast osteoclastogenesis periodontal periodontitis periosteum relate resorption rgs10 soy sscs supplementation supplements tolerability unsatisfactory	calpain candidate candidates capn1 chuk compelling consideration defect disorder distally encode fatal harlequin hi ichq ichthyosis ikka keratinocytes locus mapping mutational narrowed phospholipase r433p refined rela scaling similarities unrelated
Tagcloud (Difference) ?		alveolar avenues bones combat craniofacial destruction forearm isoflavone menopausal microbe mkp multipotent nfatc1 oscillation oscillations osteoclast osteoclastogenesis periodontal periodontitis periosteum relate resorption rgs10 soy sscs supplementation supplements tolerability unsatisfactory	calpain candidate candidates capn1 chuk compelling consideration defect disorder distally encode fatal harlequin hi ichq ichthyosis ikka keratinocytes locus mapping mutational narrowed phospholipase r433p refined rela scaling similarities unrelated
Tagcloud (Intersection) ?