RFXAP and SMARCA4

Number of citations of the paper that reports this interaction (PMID 15781111)
10

Data Source:
HPRD (in vivo, in vitro)

		RFXAP	SMARCA4
Gene Name		regulatory factor X-associated protein	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Nuclear Chromatin Heterochromatin Extracellular Space Nucleus Nucleoplasm Nuclear Euchromatin Perichromatin Fibrils Nucleolus Membrane SWI/SNF Complex Protein Complex NpBAF Complex NBAF Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Coactivator Activity P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Tat Protein Binding Nucleosomal DNA Binding Protein N-terminus Binding Androgen Receptor Binding DNA Polymerase Binding Lysine-acetylated Histone Binding
	Biological Process	Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Vasculogenesis Blastocyst Growth Blastocyst Hatching Liver Development Neural Retina Development Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Methylation-dependent Chromatin Silencing Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Glial Cell Fate Determination DNA Methylation On Cytosine Within A CG Sequence Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Keratinocyte Differentiation Negative Regulation Of Cell Growth Forebrain Development Hindbrain Development Embryonic Hindlimb Morphogenesis Aortic Smooth Muscle Cell Differentiation ATP-dependent Chromatin Remodeling Positive Regulation Of DNA Binding Positive Regulation By Host Of Viral Transcription Histone H3 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Morphogenesis Epidermis Morphogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Definitive Erythrocyte Differentiation Heart Trabecula Formation Negative Regulation Of Androgen Receptor Signaling Pathway Lens Fiber Cell Development Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Chromatin modifying enzymes Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer RMTs methylate histone arginines
Drugs
Diseases
GWAS			Coronary heart disease ( 21347282)
Protein-Protein Interactions		4 interactors: EPS8 RFX5 RFXANK SMARCA4	73 interactors: ACTB ACTL6A AHR AR ARID1A ARID1B ARID2 BRCA1 BRWD1 CARM1 CBX5 CCNE1 CDK19 CDK8 CDKN2A CDX2 CEBPA CEBPB CHD4 CHMP5 CIITA CREB1 CTNNB1 DPF3 ESR1 ETS2 FANCA GATA1 GMNN H2AFX H3F3A HIST1H3A HIST1H4F HIST2H2BE HIST2H3C HSF1 HSF4 IKZF1 KLF1 MBD3 MDM2 MED17 MED6 MKL1 MPHOSPH6 MPP6 MYC MYOCD NR3C1 NR4A2 PABPN1 PAX6 PBRM1 PHB RAP1A RB1 RBL1 RBL2 RELB RFXAP SIN3A SIN3B SMARCB1 SMARCC1 SMARCE1 SS18 SS18L1 STAT2 STAT3 STK11 TMF1 TP53 ZMYND11
Entrez ID		5994	6597
HPRD ID		03515	04459
Ensembl ID		ENSG00000133111	ENSG00000127616
Uniprot IDs		O00287	A7E2E1 B3KNW7 P51532 Q9HBD4
PDB IDs		2KW3	2GRC 2H60 3UVD
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Actin Polymerization-dependent Cell Motility Ras Protein Signal Transduction DNA Methylation On Cytosine Within A CG Sequence Definitive Erythrocyte Differentiation Aortic Smooth Muscle Cell Differentiation Exit From Mitosis Glial Cell Fate Determination Methylation-dependent Chromatin Silencing Behavioral Response To Ethanol Positive Regulation By Host Of Viral Transcription Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation On Cytosine Negative Regulation Of Androgen Receptor Signaling Pathway Nucleosome Disassembly Blastocyst Hatching Rac Protein Signal Transduction Heart Trabecula Formation Lens Fiber Cell Development Vascular Smooth Muscle Cell Differentiation Transcription, DNA-templated Regulation Of Androgen Receptor Signaling Pathway Barbed-end Actin Filament Capping Actin Crosslink Formation Dendritic Cell Migration Glial Cell Fate Commitment RNA Biosynthetic Process Small GTPase Mediated Signal Transduction Definitive Hemopoiesis Heart Trabecula Morphogenesis Blastocyst Growth Interaction With Symbiont Chromatin Silencing Lens Fiber Cell Differentiation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of DNA Binding Epidermis Morphogenesis Histone H3 Acetylation Positive Regulation Of Viral Transcription Actin Filament Capping Trabecula Morphogenesis Embryonic Hindlimb Morphogenesis Cell Fate Determination Skin Morphogenesis RNA Metabolic Process Neural Retina Development Smooth Muscle Cell Differentiation Negative Regulation Of Actin Filament Depolymerization Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Organelle Organization Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Chromatin Remodeling Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cellular Process Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Anatomical Structure Development Developmental Process Chromatin Assembly Or Disassembly System Development Multicellular Organismal Development ATP-dependent Chromatin Remodeling
Tagcloud ?		ankyrin assembles associate associates atf1 class coactivators coimmunoprecipitation compose cooperate enhanceosome leucine mhc module nlr nlrc5 nonderepressible nucleoprotein participates promoters repeats rfx5 rfxank tight transactivates w x1 x2	abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Difference) ?		ankyrin assembles associate associates atf1 class coactivators coimmunoprecipitation compose cooperate enhanceosome leucine mhc module nlr nlrc5 nonderepressible nucleoprotein participates promoters repeats rfx5 rfxank tight transactivates w x1 x2	abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Intersection) ?