SENP2 and NUP153

Number of citations of the paper that reports this interaction (PMID 12192048)
82

Data Source:
HPRD (in vivo)

		SENP2	NUP153
Gene Name		SUMO1/sentrin/SMT3 specific peptidase 2	nucleoporin 153kDa
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Gene Ontology Annotations	Cellular Component	Nuclear Pore Nucleoplasm PML Body Cytoplasmic Vesicle Nuclear Membrane	Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Nuclear Pore Nuclear Basket
	Molecular Function	Protein Binding SUMO-specific Protease Activity Protein Domain Specific Binding	DNA Binding Transporter Activity Nucleocytoplasmic Transporter Activity Protein Binding Zinc Ion Binding Structural Constituent Of Nuclear Pore Identical Protein Binding Protein Anchor
	Biological Process	Positive Regulation Of Protein Phosphorylation Proteolysis Heart Development Dorsal/ventral Axis Specification Protein Transport Wnt Signaling Pathway Protein Sumoylation Protein Desumoylation Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Binding Regulation Of DNA Endoreduplication Negative Regulation Of Chromatin Binding Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter MRNA Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Development Spongiotrophoblast Layer Development Regulation Of G1/S Transition Of Mitotic Cell Cycle	Mitotic Cell Cycle Carbohydrate Metabolic Process Mitotic Nuclear Envelope Disassembly Hexose Transport Pathogenesis Gene Expression Regulation Of Glucose Transport Protein Transport Glucose Transport Viral Process Viral Life Cycle Viral Transcription Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process Viral Entry Into Host Cell Negative Regulation Of RNA Export From Nucleus MRNA Transport Nuclear Pore Complex Assembly Transmembrane Transport Viral Penetration Into Host Nucleus
Pathways		SUMO is proteolytically processed Post-translational protein modification SUMOylation Processing and activation of SUMO	Mitotic Prophase HIV Infection Nuclear import of Rev protein Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Nuclear Envelope Breakdown SLC-mediated transmembrane transport M Phase Influenza Life Cycle HIV Life Cycle Influenza Viral RNA Transcription and Replication Rev-mediated nuclear export of HIV RNA Myoclonic epilepsy of Lafora Glycogen storage diseases Transcriptional regulation by small RNAs Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism Interferon Signaling Host Interactions of HIV factors Nuclear Pore Complex (NPC) Disassembly Regulation of Glucokinase by Glucokinase Regulatory Protein Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Interactions of Rev with host cellular proteins Influenza Infection Hexose transport Cell Cycle, Mitotic Late Phase of HIV Life Cycle Antiviral mechanism by IFN-stimulated genes Viral Messenger RNA Synthesis Metabolism of carbohydrates Glucose transport
Drugs
Diseases
GWAS			Height ( 18391951) Obesity-related traits ( 23251661)
Protein-Protein Interactions		21 interactors: AGTRAP APP ARL6IP1 AXIN1 CCDC155 CDCA5 CDK5RAP2 DAXX FUNDC1 IKBKG NEDD4L NUP153 PML RANGAP1 SUMO1 SUMO2 SUMO3 SYNE4 TMEM239 TPD52 TRIM63	24 interactors: APC BRCA1 IPO5 KPNA2 KPNB1 MAPK1 MAPK14 MAPK3 NFX1 NUP62 NUTF2 NXF1 NXF2 RAN SENP2 SMAD2 SMAD3 TNPO1 TPR TRN-GTT2-1 XPO1 XPO5 XPO7 XPOT
Entrez ID		59343	9972
HPRD ID		07002	04899
Ensembl ID			ENSG00000124789
Uniprot IDs		Q9HC62	B4DIK2 F6QR24 P49790 Q4LE47 Q7Z743
PDB IDs		1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3	2EBQ 2EBR 2EBV 2GQE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Cellular Localization Positive Regulation Of Protein Catabolic Process Protein Sumoylation Positive Regulation Of Cellular Protein Metabolic Process PML Body Organization Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Establishment Of Localization In Cell Intracellular Receptor Signaling Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Metabolic Process Mitotic Cell Cycle Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Stress Regulation Of Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process JNK Cascade Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Viral Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Stress-activated MAPK Cascade Establishment Of Organelle Localization Stress-activated Protein Kinase Signaling Cascade Nucleus Organization Cell Cycle Process Regulation Of Cellular Localization Cellular Response To Stress Mitotic Cell Cycle Process Response To Abiotic Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Activation Of MAPK Activity Organelle Localization Protein Localization To Nucleus Regulation Of Protein Localization Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Intracellular Transport Cell Surface Receptor Signaling Pathway Organelle Organization Activation Of JUN Kinase Activity Cellular Response To Stimulus Cellular Response To DNA Damage Stimulus Establishment Of Chromosome Localization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway	Nucleocytoplasmic Transport Nuclear Transport Cytoplasmic Transport Viral Process Nuclear Export Protein Transport Establishment Of Protein Localization Intracellular Transport RNA Transport Establishment Of Localization In Cell RNA Localization Protein Localization To Nucleus Intracellular Protein Transport Protein Localization Protein Import Into Nucleus Nuclear Import MRNA Transport Cellular Localization Protein Import Protein Export From Nucleus Transport Cellular Protein Localization Protein Localization To Organelle Establishment Of Protein Localization To Organelle Cellular Response To Organic Substance Protein Targeting Regulation Of Intracellular Transport Cell Cycle NLS-bearing Protein Import Into Nucleus Regulation Of Cytoskeleton Organization Gene Expression RNA Export From Nucleus Response To DsRNA Response To Organic Substance Cellular Response To Cytokine Stimulus MAPK Import Into Nucleus Viral Life Cycle Response To Growth Factor Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Transcription, DNA-templated Intracellular Transport Of Virus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Ribosomal Small Subunit Export From Nucleus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Localization Response To Epidermal Growth Factor Response To Cytokine Regulation Of Intracellular Protein Transport
Tagcloud ?		adequate aerobic atp consistently displaying exhibit glucose glycolysis glycolytic hif1alpha knockout lactate ly294002 mcf7 mef mefs metabolism protease proteases represses rescued respiration reveals senps shifts subcellular sumo sumoylate supply	acted bona breakpoints chimeras deregulate fg fide functioned gly heterodimerization hox hoxa9 nih nucleoporin nucleoporins nup214 nup98 oncogenesis oncoproteins pbx phe physically recruit repeat repeats segments transactivation transactivators vp16
Tagcloud (Difference) ?		adequate aerobic atp consistently displaying exhibit glucose glycolysis glycolytic hif1alpha knockout lactate ly294002 mcf7 mef mefs metabolism protease proteases represses rescued respiration reveals senps shifts subcellular sumo sumoylate supply	acted bona breakpoints chimeras deregulate fg fide functioned gly heterodimerization hox hoxa9 nih nucleoporin nucleoporins nup214 nup98 oncogenesis oncoproteins pbx phe physically recruit repeat repeats segments transactivation transactivators vp16
Tagcloud (Intersection) ?