RARG and RXRB

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RARG	RXRB
Gene Name		retinoic acid receptor, gamma	retinoid X receptor, beta
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Integral Component Of Membrane	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Retinoic Acid Receptor Activity Protein Binding Zinc Ion Binding Retinoid X Receptor Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity 9-cis Retinoic Acid Receptor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Tube Closure Glandular Epithelial Cell Development Retinal Pigment Epithelium Development Growth Plate Cartilage Chondrocyte Growth Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Size Anterior/posterior Pattern Specification Gene Expression Embryonic Camera-type Eye Development Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Retinoic Acid Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Transmembrane Transport Canonical Wnt Signaling Pathway Face Development Trachea Cartilage Development Prostate Gland Epithelium Morphogenesis Harderian Gland Development Cellular Response To Retinoic Acid	In Utero Embryonic Development Maternal Placenta Development Transcription Initiation From RNA Polymerase II Promoter Gene Expression Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Retinoic Acid Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Transmembrane Transport Cardiac Muscle Cell Proliferation Cellular Response To Retinoic Acid
Pathways		Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters	Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters
Drugs		Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate SR11254 4-[3-Oxo-3-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-Naphthalen-2-Yl)-Propenyl]-Benzoic Acid CD564 Dodecyl-Alpha-D-Maltoside BMS184394 R-3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID 3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID	Adapalene Bexarotene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE N-(TERT-BUTYL)-3,5-DIMETHYL-N\'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
Diseases
GWAS			Wegener's granulomatosis ( 23740775)
Protein-Protein Interactions		29 interactors: ACY3 EIF3I HMGA1 IL24 ITGB1BP2 LSR MAP6 MRPL12 MTMR6 NCOA1 NCOA3 NCOR1 NCOR2 NKX3-1 NR0B2 NR2F6 OIP5 PNRC1 PNRC2 RHPN2 RXRA RXRB RXRG SMAD3 SPHK1 SRC SRF TNIP1 ZNF576	32 interactors: AKAP13 CACNA1B GRIP1 GTF2H1 MAP4 MED1 NCOA1 NCOA3 NR0B2 NR1H2 NR1H3 NR1I2 NR2C2 NR2E3 NR3C1 NR4A2 NRIP1 PPARD PPARG PTMS RARA RARB RARG SPOP SRA1 SRC TACC2 TAF11 THRA THRB VDR ZDHHC12
Entrez ID		5916	6257
HPRD ID		01573	01578
Ensembl ID		ENSG00000172819	ENSG00000204231
Uniprot IDs		A8K3H3 B7Z4B4 F1D8P1 P13631	E9PK95 P28702 Q5STP9
PDB IDs		1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD	1H9U 1UHL
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Transcription, DNA-templated Response To Steroid Hormone Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process DNA-templated Transcription, Initiation Response To Hormone Gene Expression Cellular Response To Organic Substance Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Response To Lipid Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Steroid Hormone Mediated Signaling Pathway Regulation Of RNA Biosynthetic Process Response To Organic Cyclic Compound Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Hormone-mediated Signaling Pathway RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Cyclic Compound Cellular Response To Hormone Stimulus Cellular Response To Lipid Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gland Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Organ Development System Development Intracellular Steroid Hormone Receptor Signaling Pathway In Utero Embryonic Development Heart Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Chordate Embryonic Development Nucleobase-containing Compound Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Transcription, DNA-templated Cellular Response To Stimulus Negative Regulation Of Nucleic Acid-templated Transcription	Intracellular Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus DNA-templated Transcription, Initiation Cellular Response To Hormone Stimulus Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Response To Hormone Positive Regulation Of Cellular Biosynthetic Process Response To Lipid Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Response To Organic Substance Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death
Tagcloud ?		activating backcross chromosomes contain cosegregated enhancers fragment homology interspecific loci mapped mchr mediate none rara rarb reports responsive restriction retinoic retinoid rflvs rxr subclass syntenic terms trans variants	2riibp aa acceptor bands cdnas coding cpg deduced designated exons extra finger heterodimers intron island isoforms midst mrxr northern phylogenic spleen spliced splicing superfamily transactivation transcribed twofold zinc
Tagcloud (Difference) ?		activating backcross chromosomes contain cosegregated enhancers fragment homology interspecific loci mapped mchr mediate none rara rarb reports responsive restriction retinoic retinoid rflvs subclass syntenic terms trans variants	2riibp aa acceptor bands cdnas coding cpg deduced designated exons extra finger heterodimers intron island isoforms midst mrxr northern phylogenic spleen spliced splicing superfamily transactivation transcribed twofold zinc
Tagcloud (Intersection) ?		rxr