RAP1GAP and RALGDS

Number of citations of the paper that reports this interaction (PMID 12464615)
5

Data Source:
HPRD (in vitro)

		RAP1GAP	RALGDS
Gene Name		RAP1 GTPase activating protein	ral guanine nucleotide dissociation stimulator
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytosol Membrane	Nucleus Cytosol Brush Border
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding Ras GTPase Binding Protein Homodimerization Activity Rap GTPase Activator Activity	Small GTPase Regulator Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Signal Transduction Metabolic Process Regulation Of Ras GTPase Activity Positive Regulation Of Rap GTPase Activity Negative Regulation Of Microvillus Assembly	Ras Protein Signal Transduction Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Rap1 signalling Adaptive Immune System	Signalling to ERKs Signalling by NGF Signalling to RAS p38MAPK events NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS		Liver enzyme levels ( 18940312)
Protein-Protein Interactions		15 interactors: BRAF CDK1 CSNK1G2 DYNC1I1 GNAZ MAP1LC3B MAPK6 MEX3B MLLT4 PFN2 PLK1 PRKACA RALGDS RAP1A ZBTB12	23 interactors: ARRB1 ARRB2 CD68 CNKSR1 HRAS KRAS LRPAP1 MAPK3 MLLT4 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2
Entrez ID		5909	5900
HPRD ID		02609	03371
Ensembl ID		ENSG00000076864	ENSG00000160271
Uniprot IDs		P47736	B7Z753 E7ER93 E7ERZ0 Q12967 Q6PCE1 Q6ZSD5 Q8N4Y1
PDB IDs		1SRQ 3BRW	1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Catalytic Activity Mitotic Nuclear Envelope Disassembly Regulation Of Synaptic Vesicle Transport Nuclear Envelope Disassembly Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Neurotransmitter Secretion Activation Of MAPKK Activity Nuclear Envelope Organization Positive Regulation Of Protein Modification Process Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Activation Of Protein Kinase Activity Response To Growth Factor Regulation Of Protein Phosphorylation Regulation Of Synaptic Transmission Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Synaptic Vesicle Exocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Rap GTPase Activity Positive Regulation Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Nucleus Organization Positive Regulation Of Protein Metabolic Process Phosphorylation Regulation Of Protein Kinase Activity Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neurotransmitter Secretion Regulation Of Rap GTPase Activity Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Neurotransmitter Transport Regulation Of Rap Protein Signal Transduction Regulation Of Exocytosis Positive Regulation Of MAPK Cascade Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Endothelial Barrier Protein Localization To Chromosome Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Kinase Activity	Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Rap Protein Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Rap GTPase Activity Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Intracellular Signal Transduction Regulation Of Rap GTPase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Rap Protein Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Positive Regulation Of Phosphorylation Blood Coagulation Regulation Of Phosphorus Metabolic Process Hemostasis Positive Regulation Of Protein Modification Process Signaling Cellular Response To Stimulus Cell Communication Platelet Activation Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Catalytic Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Synaptic Transmission Response To Wounding Regulation Of Protein Kinase Activity Establishment Of Endothelial Barrier Response To Stimulus Regulation Of GTPase Activity Regulation Of Kinase Activity Positive Regulation Of Metabolic Process Epithelial Cell Development Regulation Of Cell Migration Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		autophosphorylated burst c3g crk detrimental fascin filamentous forced gradual gtpase guanine holds hyperactivation imperative irrespective labile microspikes motile n17rap1 presumed protrusions recruits releasing reverses sh3 unidentified v12rap1	abi1 atlas bitbucket ccnd3 ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Difference) ?		autophosphorylated burst c3g crk detrimental fascin filamentous forced gradual gtpase guanine holds hyperactivation imperative irrespective labile microspikes motile n17rap1 presumed protrusions recruits releasing reverses sh3 unidentified v12rap1	abi1 atlas bitbucket ccnd3 ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Intersection) ?