RAP1A and RASA3

Number of citations of the paper that reports this interaction (PMID 2158984)
25

Data Source:
HPRD (in vivo)

		RAP1A	RASA3
Gene Name		RAP1A, member of RAS oncogene family	RAS p21 protein activator 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Early Endosome Late Endosome Cytosol Plasma Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Cytoplasm Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Transporter Activity Ras GTPase Binding Rap Guanyl-nucleotide Exchange Factor Activity Protein Complex Binding	GTPase Activator Activity Ras GTPase Activator Activity Calcium-release Channel Activity Metal Ion Binding
	Biological Process	Activation Of MAPKK Activity Energy Reserve Metabolic Process Signal Transduction Blood Coagulation Positive Regulation Of Neuron Projection Development Protein Transport Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Nerve Growth Factor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis	Signal Transduction Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Calcium Ion Transmembrane Transport
Pathways		Signalling to ERKs Signalling by NGF Prolonged ERK activation events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling NGF signalling via TRKA from the plasma membrane GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) ARMS-mediated activation Rap1 signalling Platelet activation, signaling and aggregation Frs2-mediated activation Adaptive Immune System
Drugs
Diseases
GWAS		Osteoporosis ( 20548944)
Protein-Protein Interactions		41 interactors: APBB1IP ARHGEF1 BIN1 BMX BRAF FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A KRIT1 MLLT4 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALA RALGDS RAP1GAP RAP1GDS1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA4 TCEB3 TNFRSF10C	5 interactors: APP FES GNB2L1 HCK RAP1A
Entrez ID		5906	22821
HPRD ID		01545	05537
Ensembl ID		ENSG00000116473	ENSG00000185989
Uniprot IDs		A8KAH9 P62834	F8W6X8 Q14644
PDB IDs		1C1Y 1GUA 3KUC
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Rap GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Regulation Of Ras GTPase Activity Regulation Of Rap GTPase Activity Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Regulation Of Rap Protein Signal Transduction Signal Transduction Cell Communication Regulation Of Metabolic Process Cellular Response To Stimulus Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Ras Protein Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Apoptotic Process Regulation Of Cell Death Cell Activation Regulation Of Protein Kinase Activity Negative Regulation Of Signaling Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Platelet Activation Regulation Of Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Lyase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Differentiation	Regulation Of Vesicle-mediated Transport Positive Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Component Biogenesis Peptidyl-tyrosine Autophosphorylation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Protein Complex Assembly Cell Differentiation Regulation Of Protein Tyrosine Kinase Activity Regulation Of Phagocytosis Regulation Of Neuron Differentiation Respiratory Burst After Phagocytosis Regulation Of Cellular Component Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neurogenesis Positive Regulation Of Protein Polymerization Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of Peptidase Activity Anatomical Structure Development Leukocyte Migration Involved In Immune Response Synaptic Growth At Neuromuscular Junction Positive Regulation Of CAMP Catabolic Process Regulation Of Exocytosis Regulation Of Cell Development Regulation Of Cell Shape Enzyme Linked Receptor Protein Signaling Pathway Collateral Sprouting In Absence Of Injury Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Endocytosis Platelet Activation Developmental Process Positive Regulation Of Cytoskeleton Organization Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Hydrolase Activity Protein Autophosphorylation Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Neuron Projection Development Positive Regulation Of Cellular Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Respiratory Burst Involved In Defense Response Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Translation Positive Regulation Of Protein Metabolic Process Axon Choice Point Recognition Negative Regulation Of Oxidative Stress-induced Neuron Death
Tagcloud ?		bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa
Tagcloud (Difference) ?		bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa
Tagcloud (Intersection) ?