RAD51 and RAD51C

Number of citations of the paper that reports this interaction (PMID 16395335)
58

Data Source:
BioGRID (imaging technique)
HPRD (in vivo)

		RAD51	RAD51C
Gene Name		RAD51 recombinase	RAD51 paralog C
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Microtubule Organizing Center PML Body Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Replication Fork Cytoplasm Mitochondrion Rad51B-Rad51C-Rad51D-XRCC2 Complex Rad51C-XRCC3 Complex Perinuclear Region Of Cytoplasm Holliday Junction Resolvase Complex
	Molecular Function	Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding Identical Protein Binding Single-stranded DNA-dependent ATPase Activity DNA Polymerase Binding	Four-way Junction DNA Binding DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Crossover Junction Endodeoxyribonuclease Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Unwinding Involved In DNA Replication DNA Repair Double-strand Break Repair DNA Recombination Mitotic Recombination Cellular Response To DNA Damage Stimulus Meiotic Nuclear Division Reciprocal Meiotic Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Ligation Protein Homooligomerization Cellular Response To Ionizing Radiation Cellular Response To Camptothecin	Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair DNA Recombination Sister Chromatid Cohesion Female Meiosis Sister Chromatid Cohesion Reciprocal Meiotic Recombination Male Meiosis I Spermatogenesis Blood Coagulation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Pathways		Assembly of the RAD51-ssDNA nucleoprotein complex Homologous DNA pairing and strand exchange Meiotic recombination Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Presynaptic phase of homologous DNA pairing and strand exchange	Meiotic recombination Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Primary tooth development (time to first tooth eruption) ( 23704328) Testicular germ cell tumor ( 23666239 23666240)
Protein-Protein Interactions		42 interactors: ABL1 ATM ATRX BCCIP BLM BRCA1 BRCA2 CASP3 CASP7 CHD3 CHEK1 DMC1 DNAJA3 ERCC2 FANCD2 FBXO18 HID1 HNRNPC IRS1 MDC1 NXF1 PFN1 RAD18 RAD51AP1 RAD51AP2 RAD51C RAD52 RAD54B RAD54L RPA1 RPA3 SFR1 SUMO1 SWI5 SWSAP1 TP53 UBE2I UGDH UHRF2 VIM WRN ZDHHC17	6 interactors: APP RAD51 RAD51B RAD51D SWSAP1 XRCC3
Entrez ID		5888	5889
HPRD ID		01557	04143
Ensembl ID		ENSG00000051180	ENSG00000108384
Uniprot IDs		Q06609	O43502
PDB IDs		1B22 1N0W
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair Via Homologous Recombination Recombinational Repair Double-strand Break Repair DNA Recombination Cellular Response To Stress Response To Stress Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Radiation Cellular Nitrogen Compound Metabolic Process Chromosome Organization Response To Ionizing Radiation Organelle Organization Cell Cycle Nitrogen Compound Metabolic Process Cellular Response To Stimulus DNA Duplex Unwinding DNA Geometric Change Response To Abiotic Stimulus Regulation Of Cell Cycle Response To Stimulus Cell Cycle Process DNA-dependent DNA Replication DNA Replication Signal Transduction In Response To DNA Damage Meiotic Nuclear Division Cellular Response To Ionizing Radiation DNA Conformation Change Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Cell Aging Response To UV Meiotic Cell Cycle Cellular Response To Radiation DNA Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Process Cellular Metabolic Process Replication Fork Processing Cellular Response To Hydroxyurea Intrinsic Apoptotic Signaling Pathway Meiosis I Response To Gamma Radiation Signal Transduction By P53 Class Mediator DNA Recombinase Assembly Regulation Of Response To DNA Damage Stimulus	Double-strand Break Repair Via Homologous Recombination Recombinational Repair Double-strand Break Repair DNA Recombination DNA Repair Reciprocal Meiotic Recombination Cellular Response To DNA Damage Stimulus DNA Metabolic Process Meiosis I Positive Regulation Of Mitotic Cell Cycle Cellular Response To Stress Meiotic Nuclear Division Response To Stress Meiotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Mitotic Recombination Positive Regulation Of Cell Cycle Reproduction Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Cellular Nitrogen Compound Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process Cellular Response To Stimulus Synaptic Growth At Neuromuscular Junction Resolution Of Mitotic Recombination Intermediates Resolution Of Recombination Intermediates Strand Invasion Collateral Sprouting In Absence Of Injury Positive Regulation Of DNA Ligation Cellular Response To Camptothecin Response To Camptothecin Regulation Of Cell Cycle Collateral Sprouting Axon Midline Choice Point Recognition DNA Recombinase Assembly Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cell Cycle Process Positive Regulation Of Spindle Checkpoint Axon Choice Point Recognition
Tagcloud ?		boundary box cerevisiae consisting damaging declined delta dosage dsc1 elements enhances fluctuate fluctuation frequency mbf1 mbp1 mcb meiosis meiotic mitotic mlu rad54 recombination saccharomyces spore sporulation swi6 transcript viability	alu bisulfite chorionic collaborating conceived departments developmentally epimutation epimutations imprinted infrequent interspersed ivm lep line1 lit1 meg mest nanog nespas newborns nr3c1 oct4 peg3 pluripotency pyrosequencing reproduction snrpn villus
Tagcloud (Difference) ?		boundary box cerevisiae consisting damaging declined delta dosage dsc1 elements enhances fluctuate fluctuation frequency mbf1 mbp1 mcb meiosis meiotic mitotic mlu rad54 recombination saccharomyces spore sporulation swi6 transcript viability	alu bisulfite chorionic collaborating conceived departments developmentally epimutation epimutations imprinted infrequent interspersed ivm lep line1 lit1 meg mest nanog nespas newborns nr3c1 oct4 peg3 pluripotency pyrosequencing reproduction snrpn villus
Tagcloud (Intersection) ?