RAD9A and FEM1B

Number of citations of the paper that reports this interaction (PMID 19330022)
1

Data Source:
BioGRID (pull down)

		RAD9A	FEM1B
Gene Name		RAD9 homolog A (S. pombe)	fem-1 homolog b (C. elegans)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Checkpoint Clamp Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding	Ubiquitin-protein Transferase Activity Death Receptor Binding Protein Binding
	Biological Process	DNA Replication Checkpoint DNA Damage Checkpoint DNA Catabolic Process, Exonucleolytic DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Intra-S DNA Damage Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Apoptotic Process Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of DNA Damage Checkpoint
Pathways		G2/M Checkpoints Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS			Major depressive disorder ( 23377640)
Protein-Protein Interactions		27 interactors: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CHEK2 CLSPN COPS5 DNAJC7 FEM1B HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 PCNA RAD17 RAD9B RPA1 RPA2 SF3B3 TOPBP1	8 interactors: APAF1 FAS GLI1 HIF1AN KIAA0319 NKX3-1 PPM1F RAD9A
Entrez ID		5883	10116
HPRD ID		04788	16889
Ensembl ID		ENSG00000172613
Uniprot IDs		Q99638	Q9UK73
PDB IDs		3A1J 3G65 3GGR
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair Cellular Response To Stress Mismatch Repair Cell Cycle Process DNA Metabolic Process Cell Cycle Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cell Cycle DNA Recombination Response To Stress Regulation Of Cell Cycle Mitotic Cell Cycle Checkpoint Negative Regulation Of DNA Metabolic Process Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cellular Aromatic Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Process Response To Ionizing Radiation Heterocycle Metabolic Process Double-strand Break Repair Cellular Nitrogen Compound Metabolic Process Meiotic Mismatch Repair Apoptotic Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of DNA Recombination Regulation Of DNA Recombination Cellular Response To Stimulus B Cell Activation Response To Radiation DNA Replication Positive Regulation Of Helicase Activity Meiotic Nuclear Division Somatic Recombination Of Immunoglobulin Gene Segments Apoptotic Process Somatic Diversification Of Immunoglobulins Programmed Cell Death Mitotic DNA Integrity Checkpoint Cell Death Meiotic Cell Cycle Death Meiosis I Response To Abiotic Stimulus B Cell Activation Involved In Immune Response Somatic Hypermutation Of Immunoglobulin Genes	Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Endopeptidase Activity Zymogen Activation Cellular Response To Oxygen Levels Regulation Of Peptidase Activity Positive Regulation Of Signal Transduction Regulation Of Proteolysis Regulation Of Apoptotic Process Protein Processing Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Drug Neuron Apoptotic Process Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Programmed Cell Death Neuron Death Positive Regulation Of Hydrolase Activity Positive Regulation Of Response To DNA Damage Stimulus Cell Death Death Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Tube Morphogenesis Peptidyl-histidine Hydroxylation Response To G1 DNA Damage Checkpoint Signaling Peptidyl-asparagine Hydroxylation Positive Regulation Of Protein Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Metabolic Process Peptidyl-aspartic Acid Hydroxylation Motor Neuron Apoptotic Process Positive Regulation Of Androgen Secretion Cellular Response To Stimulus Regulation Of Response To DNA Damage Stimulus
Tagcloud ?		11q13 250k 4ebp1 8p12 affymetrix amplicon amplicons amplification arrays coamplification coamplifications coexpression cores eif4ebp1 enabled encompassing fgf19 fgf3 fgf4 fgfr1 gab2 gistic nspi oncogenes pak1 ppapdc1b rps6kb2 s6k2 synergy
Tagcloud (Difference) ?		11q13 250k 4ebp1 8p12 affymetrix amplicon amplicons amplification arrays coamplification coamplifications coexpression cores eif4ebp1 enabled encompassing fgf19 fgf3 fgf4 fgfr1 gab2 gistic nspi oncogenes pak1 ppapdc1b rps6kb2 s6k2 synergy
Tagcloud (Intersection) ?