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BARD1 and AP1B1
Number of citations of the paper that reports this interaction (PMID
22990118
)
7
Data Source:
BioGRID
(two hybrid)
BARD1
AP1B1
Gene Name
BRCA1 associated RING domain 1
adaptor-related protein complex 1, beta 1 subunit
Image
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
BRCA1-BARD1 Complex
Intracellular Membrane-bounded Organelle
BRCA1-A Complex
Golgi Membrane
Lysosomal Membrane
Cytosol
Clathrin Adaptor Complex
Cytoplasmic Vesicle Membrane
Clathrin-coated Vesicle Membrane
Trans-Golgi Network Membrane
Molecular Function
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Kinase Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Transporter Activity
Protein Binding
Protein Transporter Activity
Protein Kinase Binding
Biological Process
Tissue Homeostasis
DNA Repair
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Protein Ubiquitination
Negative Regulation Of MRNA 3'-end Processing
Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Protein Export From Nucleus
Protein K6-linked Ubiquitination
Intracellular Protein Transport
Post-Golgi Vesicle-mediated Transport
Viral Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Regulation Of Defense Response To Virus By Virus
Membrane Organization
Pathways
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
HIV Infection
Host Interactions of HIV factors
Golgi Associated Vesicle Biogenesis
The role of Nef in HIV-1 replication and disease pathogenesis
Nef mediated downregulation of MHC class I complex cell surface expression
Clathrin derived vesicle budding
Lysosome Vesicle Biogenesis
MHC class II antigen presentation
trans-Golgi Network Vesicle Budding
Adaptive Immune System
Drugs
Diseases
GWAS
Neuroblastoma (
22941191
21124317
)
Neuroblastoma (high-risk) (
19412175
)
Carotid atherosclerosis in HIV infection (
20009918
)
Protein-Protein Interactions
107 interactors:
ACP1
AKIP1
AP1B1
ASH2L
ATP1B1
ATP1B3
BCCIP
BCL3
BRCA1
BRD7
BRIP1
CAP1
CASC1
CCDC136
CEP70
CHD3
CNTN4
COL1A1
COMMD1
CRIPAK
CSTF1
DCC
DDX39B
EWSR1
EXOC5
FAM9B
FEZ1
FKBP1A
FKBP2
FKBP3
FUCA1
GIT1
GOLGA2
GPRASP2
H2AFX
HAP1
HIST2H2AC
HNRNPC
HNRNPLL
HSPA14
IDI1
IKBKAP
ING5
KAT5
KAT7
KBTBD7
KRT40
LDOC1
LGALS3
LGALS8
LRIF1
MDC1
MRPS22
MSH2
MSH3
MSH6
MT2A
ND1
NFKBIA
NPC2
OLA1
PCBP2
PDXK
PDZD8
PIAS1
PIAS4
POLR2A
POLR2H
POMZP3
POU2F1
PSMA7
PTN
RBBP8
RBMY2BP
RPS20
SELENBP1
SETDB1
SMCHD1
SNRNP200
SNX3
SPAG5
SRSF2
TCERG1
TMEM248
TOP1
TP53
TRAF1
TRAPPC11
TRAPPC8
TULP2
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2N
UBE2U
UBE2W
UBE3A
UBR5
UBXN1
WDR61
XRCC6
ZFP64
ZHX1
ZNF121
22 interactors:
AMPH
AP1G1
AP1M1
AP1M2
ARF1
ARF5
ARF6
ARRB2
ATF7IP
ATM
ATR
BARD1
BUB1
BUB1B
CLTC
CREBBP
KIF13A
NTRK2
PIP5K1C
PRKDC
SHBG
SMAD2
Entrez ID
580
162
HPRD ID
03354
02541
Ensembl ID
ENSG00000138376
ENSG00000100280
Uniprot IDs
Q99728
Q10567
PDB IDs
1JM7
2NTE
2R1Z
3C5R
3FA2
4HMY
Enriched GO Terms of Interacting Partners
?
Cellular Response To DNA Damage Stimulus
DNA Repair
Protein Polyubiquitination
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Response To Stress
Nitrogen Compound Metabolic Process
Double-strand Break Repair
DNA Metabolic Process
Gene Expression
Chromosome Organization
Regulation Of Metabolic Process
Protein K48-linked Ubiquitination
Regulation Of Nitrogen Compound Metabolic Process
RNA Metabolic Process
Protein Modification By Small Protein Conjugation
RNA Biosynthetic Process
Transcription, DNA-templated
Regulation Of Protein Ubiquitination
Cellular Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Response To Stress
Cell Cycle Checkpoint
DNA Recombination
Negative Regulation Of Cellular Metabolic Process
Regulation Of RNA Biosynthetic Process
Macromolecule Biosynthetic Process
Protein Ubiquitination
Positive Regulation Of Cellular Metabolic Process
Meiotic Mismatch Repair
Cellular Macromolecule Biosynthetic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Nucleic Acid-templated Transcription
Modification-dependent Protein Catabolic Process
Chromatin Organization
DNA Damage Checkpoint
Cellular Macromolecule Catabolic Process
Immune System Process
Viral Process
Cell Cycle
Proteolysis Involved In Cellular Protein Catabolic Process
Organelle Organization
Cellular Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Transcription, DNA-templated
Post-Golgi Vesicle-mediated Transport
Regulation Of Defense Response To Virus By Virus
Vesicle-mediated Transport
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Protein Localization
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Organelle Organization
Golgi Vesicle Transport
Protein Transport
Establishment Of Protein Localization
Cellular Localization
Viral Process
Regulation Of Defense Response To Virus
Establishment Of Vesicle Localization
Melanosome Organization
Pigment Granule Organization
Vesicle Localization
Cell Cycle
Cell Cycle Checkpoint
Antigen Processing And Presentation Of Peptide Antigen
Cell Cycle Process
Regulation Of Cellular Response To Heat
Regulation Of Cellular Component Organization
Establishment Of Localization In Cell
Mitotic Spindle Assembly Checkpoint
Spindle Assembly Checkpoint
Mitotic Spindle Checkpoint
Antigen Processing And Presentation
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Chromosome Segregation
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Establishment Of Organelle Localization
Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Mitotic Nuclear Division
Spindle Checkpoint
Cell Differentiation
Regulation Of Mitotic Metaphase/anaphase Transition
Mitotic Cell Cycle Checkpoint
Negative Regulation Of Proteolysis
Cellular Protein Localization
Response To Gamma Radiation
Negative Regulation Of Protein Processing
Cellular Pigmentation
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Response To Temperature Stimulus
Endosome To Melanosome Transport
Pigment Granule Maturation
Regulation Of Protein Processing
Negative Regulation Of Proteasomal Protein Catabolic Process
Tagcloud
?
10ng
agreed
atr
belonged
biosynthetic
biphenyls
brca2
dioxin
fancd2
figf
hands
immunoblots
impulses
kcnma1
lactational
mycn
ndl
neurobiological
npy4r
ontology
operator6
pcbs
performances
projection
rad51
scn1a
summation
transcriptomic
validating
Tagcloud (Difference)
?
10ng
agreed
atr
belonged
biosynthetic
biphenyls
brca2
dioxin
fancd2
figf
hands
immunoblots
impulses
kcnma1
lactational
mycn
ndl
neurobiological
npy4r
ontology
operator6
pcbs
performances
projection
rad51
scn1a
summation
transcriptomic
validating
Tagcloud (Intersection)
?