PTPN2 and STAT5A

Number of citations of the paper that reports this interaction (PMID 15588985)
37

Data Source:
HPRD (in vitro, in vivo)

		PTPN2	STAT5A
Gene Name		protein tyrosine phosphatase, non-receptor type 2	signal transducer and activator of transcription 5A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane	Nucleoplasm Cytosol
	Molecular Function	Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding Protein Kinase Binding Syntaxin Binding Receptor Tyrosine Kinase Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding
	Biological Process	Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipid Storage Cytokine-mediated Signaling Pathway B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Glucose Homeostasis Negative Regulation Of Macrophage Differentiation Positive Regulation Of Gluconeogenesis Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Chemotaxis Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-2-mediated Signaling Pathway Negative Regulation Of Prolactin Signaling Pathway Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Allantoin Metabolic Process Luteinization Natural Killer Cell Differentiation Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process JAK-STAT Cascade Female Pregnancy Lactation Peptidyl-tyrosine Phosphorylation Regulation Of Steroid Metabolic Process Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Positive Regulation Of Natural Killer Cell Differentiation Negative Regulation Of Mast Cell Apoptotic Process T Cell Differentiation In Thymus Prolactin Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation T Cell Homeostasis Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Creatinine Metabolic Process Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Inflammatory Response Positive Regulation Of Mast Cell Differentiation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Prostate Gland Epithelium Morphogenesis Epithelial Cell Differentiation Involved In Prostate Gland Development Mammary Gland Epithelium Development Positive Regulation Of Mast Cell Proliferation Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Pathways			Signaling by PDGF Signaling by FGFR in disease Cytokine Signaling in Immune system Signaling by ERBB4 Signaling by SCF-KIT Signaling by Interleukins Nuclear signaling by ERBB4 Downstream signal transduction Signaling by FGFR1 mutants Interleukin-7 signaling Signaling by FGFR mutants Interleukin-2 signaling Prolactin receptor signaling Signaling by FGFR1 fusion mutants Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Growth hormone receptor signaling
Drugs
Diseases
GWAS		C-reactive protein ( 21300955) Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) Crohn's disease ( 18587394 17554261 17554300 21102463) Esophageal cancer (squamous cell) ( 22960999) Rheumatoid arthritis ( 22446963) Type 1 diabetes ( 19430480 17554260 18978792) Type 1 diabetes autoantibodies ( 21829393)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		18 interactors: CDK1 CDK2 CDK5 EGFR FKBP4 GHR INSR ITGA1 JAK1 JAK3 KPNB1 PDGFRB SHC1 SRC STAT1 STAT3 STAT5A STAT5B	72 interactors: AQP11 BMX BRCA1 BRCA2 BTK CBL CCR5 CD247 CEBPB CENPJ CRK CRKL CSNK2B CTLA4 CYP2C9 EGFR EP300 EPAS1 EPOR ERBB4 ESR1 ESR2 FN1 GHR GLUD1 GNB2 HELZ IL2RB IL2RG IL7R INSR JAK1 JAK2 JAK3 KIT LCK LEF1 MAGEA12 MAPK1 MAPK3 MRPS6 NARF NCOR2 NLK NMI NR3C1 PDGFRA PDGFRB POM121C POU2F1 PPIB PPP2CA PRMT1 PRTFDC1 PTPN1 PTPN11 PTPN2 RBMX SHC1 SRC STAP2 STAT1 STAT3 STAT5B SYK TCF12 TEK TSLP TXNDC11 UGT2B4 WASH2P ZNF596
Entrez ID		5771	6776
HPRD ID		06768	03301
Ensembl ID		ENSG00000175354	ENSG00000126561
Uniprot IDs		A8K3N4 K7ENG3 K7EQG9 P17706 Q59F91	A8K6I5 K7EK35 P42229 Q59GY7
PDB IDs		1L8K
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Cell Proliferation Response To Organonitrogen Compound Cellular Response To Hormone Stimulus Peptidyl-tyrosine Phosphorylation Response To Peptide Hormone Response To Hormone Response To Growth Hormone Peptidyl-amino Acid Modification Response To Peptide Intracellular Signal Transduction Cellular Response To Organic Substance JAK-STAT Cascade Positive Regulation Of MAP Kinase Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Signaling Positive Regulation Of DNA Metabolic Process Cell Communication Protein Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Regulation Of MAP Kinase Activity Phosphorylation Positive Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Proliferation Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Biosynthetic Process Signal Transduction Protein Autophosphorylation Positive Regulation Of Metabolic Process Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Response To Cytokine Activation Of Protein Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity	Cellular Response To Organic Substance Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Hormone Cell Surface Receptor Signaling Pathway Cellular Response To Hormone Stimulus Protein Autophosphorylation Cellular Response To Stimulus Immune Response Signal Transduction Immune System Process Cellular Response To Organonitrogen Compound Peptidyl-tyrosine Phosphorylation Signaling Cell Communication Cellular Response To Cytokine Stimulus Regulation Of Immune Response Defense Response Response To Cytokine Positive Regulation Of Cellular Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Peptidyl-amino Acid Modification Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cellular Response To Peptide Hormone Stimulus Response To Stimulus Cellular Response To Growth Hormone Stimulus Innate Immune Response Cellular Response To Peptide Response To Organonitrogen Compound Regulation Of Immune System Process Cellular Response To Growth Factor Stimulus Regulation Of Cell Proliferation Organ Development Response To Growth Factor Cytokine-mediated Signaling Pathway JAK-STAT Cascade Regulation Of MAPK Cascade Response To Peptide Hormone Neurotrophin TRK Receptor Signaling Pathway Response To Peptide Fc Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Kinase Activity Response To Growth Hormone Positive Regulation Of Metabolic Process Neurotrophin Signaling Pathway Anatomical Structure Development
Tagcloud ?		6alpha acidic astrocytes astroglial atf6alpha ciliary cntf deactivation dissect fibrillary gfap glia glial infarct lif master mcao neurotrophic peri phenylbutyrate protein78 scar stressors tc thapsigargin transducer tunicamycin unfolded	advantaged apor arose b8 ba character coincides committed derive die dn epo epor erythropoietin f3epor homeotic hox hypothesize naturally normally preexisting shortened subclones switch truncated unexplored uniquely
Tagcloud (Difference) ?		6alpha acidic astrocytes astroglial atf6alpha ciliary cntf deactivation dissect fibrillary gfap glia glial infarct lif master mcao neurotrophic peri phenylbutyrate protein78 scar stressors tc thapsigargin transducer tunicamycin unfolded	advantaged apor arose b8 ba character coincides committed derive die dn epo epor erythropoietin f3epor homeotic hox hypothesize naturally normally preexisting shortened subclones switch truncated unexplored uniquely
Tagcloud (Intersection) ?