USP28 and USP8

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		USP28	USP8
Gene Name		ubiquitin specific peptidase 28	ubiquitin specific peptidase 8
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Protein Complex	Acrosomal Vesicle Nucleoplasm Cytoplasm Early Endosome Golgi Apparatus Cytosol Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding SH3 Domain Binding
	Biological Process	DNA Damage Checkpoint DNA Repair Cellular Response To DNA Damage Stimulus Cell Proliferation Response To Ionizing Radiation Protein Deubiquitination Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process	Mitotic Cytokinesis Endosome Organization Ras Protein Signal Transduction Cell Proliferation Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways			Signaling by ERBB2 Downregulation of ERBB2:ERBB3 signaling misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ATXN3L BAP1 CLSPN ESPL1 JOSD1 KDM1A MDC1 NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A RFFL SENP8 STAM STAMBP TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8	30 interactors: BIRC6 CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 GRAP2 GRB2 KIF23 NBR1 PJA1 PLA2G2A RASGRF1 RNF41 SLBP SPP1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ
Entrez ID		57646	9101
HPRD ID		15632	04405
Ensembl ID		ENSG00000048028	ENSG00000138592
Uniprot IDs		B4E3L3 Q96RU2	P40818
PDB IDs		2LVA	1WHB 2A9U 2GFO 2GWF 3N3K
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Cellular Protein Modification Process Regulation Of Proteolysis Catabolic Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Protein K63-linked Deubiquitination Histone Deubiquitination Cellular Metabolic Process Monoubiquitinated Protein Deubiquitination Histone Modification DNA Repair Metabolic Process Mitotic Cell Cycle Regulation Of Metabolic Process Chromosome Organization Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To DNA Damage Stimulus Chromatin Modification Negative Regulation Of Protein Metabolic Process Cellular Response To Stress Mitotic Cell Cycle Process Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin Organization Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Cell Cycle Process DNA Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process	Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Mitotic Metaphase Plate Congression Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Establishment Of Chromosome Localization Vacuolar Transport Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cell Cycle Process Regulation Of Centrosome Duplication Cell Cycle Mitotic Nuclear Division Regulation Of Centrosome Cycle Mitotic Cell Cycle Process Endosomal Transport Regulation Of Organelle Organization Nucleus Organization Mitotic Cell Cycle Regulation Of Cell Division Regulation Of Microtubule Cytoskeleton Organization Cell Division Membrane Organization Regulation Of Microtubule-based Process Regulation Of Cell Cycle Process Intracellular Transport Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Chromosome Segregation Negative Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Nuclear Division Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Establishment Of Localization In Cell Regulation Of Cytoskeleton Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Organelle Localization Regulation Of ERBB Signaling Pathway Virion Assembly Viral Life Cycle Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Regulation Of Cellular Process Cellular Protein Catabolic Process Protein Transport
Tagcloud ?		acetylcysteine antioxidants brief cyld cylindromatosis deprivation diminished dram generating glutaredoxin glutathione glycolysis grx2a hepg2 homolog isoform mediation menadione modulator peptidase peroxide pten ros state steady superoxide tensin tigar transfectants	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Difference) ?		acetylcysteine antioxidants brief cyld cylindromatosis deprivation diminished dram generating glutaredoxin glutathione glycolysis grx2a hepg2 homolog isoform mediation menadione modulator peptidase peroxide pten ros state steady superoxide tensin tigar transfectants	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Intersection) ?