PTN and TAC3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PTN	TAC3
Gene Name		pleiotrophin	tachykinin 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum	Extracellular Region Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Protein Phosphatase Inhibitor Activity Growth Factor Activity Heparin Binding	Receptor Binding Protein Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Nervous System Development Learning Positive Regulation Of Cell Proliferation Bone Mineralization Negative Regulation Of Catalytic Activity Positive Regulation Of Cell Division	Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy
Pathways			G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Tachykinin receptors bind tachykinins Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		97 interactors: ACTB ALK APOBEC3G ARIH2 ARL15 ATP5C1 ATRX BAG6 BARD1 BCCIP BCL2L1 BLOC1S1 BMI1 BTBD2 C11orf58 C7orf25 CAAP1 CACNB4 CAPZB CCDC53 CDH10 CDK5RAP2 CGA CHD3 COX6C CRCT1 CRELD1 CSTA CYP2E1 DFNA5 DNAJB11 DUSP12 EIF3F EVA1A FEZ1 FTL GADD45A GADD45G GIPC2 GLYAT GNB2L1 GPD1 GPRASP2 GSK3B GSTP1 GTF2F1 HGH1 HSPBAP1 ITSN2 KPNB1 LAMA4 LUC7L2 MAD2L1BP MKKS MLLT3 MRPL44 MYCBP NAP1L5 NCAN NEK6 NUDT21 P4HB PFDN1 PIAS4 PLXNB2 PMF1 PPP2CA PSMB10 PSMD11 PSMD2 PTPRS PTPRZ1 RBM23 RIT1 RPLP1 SAT1 SDC1 SDC3 SGSM2 SGTA SLC25A36 SNCAIP SPIN1 SSR1 STC2 SUPT7L TAC3 TAF1D TBRG4 TOMM20 TP53BP2 TSC22D1 TXNDC9 UBQLN1 UBQLN4 UTP3 WFDC2	10 interactors: CCDC90B FEZ1 GPRASP1 IKBKAP PTN TACR1 TACR2 TACR3 UBC UBR1
Entrez ID		5764	6866
HPRD ID		01199	08877
Ensembl ID		ENSG00000105894	ENSG00000166863
Uniprot IDs		P21246	Q9UHF0
PDB IDs			1P9F
Enriched GO Terms of Interacting Partners?		Cell Cycle Nitrogen Compound Metabolic Process Apoptotic Process Central Nervous System Development Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Cell Death Regulation Of Cell Cycle Death Regulation Of Protein Catabolic Process Negative Regulation Of Transferase Activity Response To Endoplasmic Reticulum Stress Regulation Of Cell Death Regulation Of Cellular Process Signal Transduction By P53 Class Mediator Cell Cycle Process Negative Regulation Of Cell Cycle Positive Regulation Of Transferase Activity Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Brain Development Nervous System Development Regulation Of Intrinsic Apoptotic Signaling Pathway Signal Transduction In Response To DNA Damage Positive Regulation Of Protein Modification Process Viral Process Developmental Process Head Development Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Process Heterocycle Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Metabolic Process Anatomical Structure Development Regulation Of Signaling Cellular Response To Stress Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity	Tachykinin Receptor Signaling Pathway Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Operant Conditioning Neuropeptide Signaling Pathway Positive Regulation Of Vascular Permeability Learning Regulation Of Muscle Contraction Regulation Of Vascular Permeability Positive Regulation Of Blood Pressure Response To Morphine Learning Or Memory Response To Electrical Stimulus Excretion Cognition Blood Circulation Smooth Muscle Contraction Cellular Response To Stimulus Positive Regulation Of Acetylcholine Secretion, Neurotransmission Response To Abiotic Stimulus Single-organism Behavior Response To Ammonium Ion Negative Regulation Of Signaling Cellular Response To Leucine G-protein Coupled Receptor Catabolic Process Positive Regulation Of Synaptic Transmission Response To Estradiol Intestine Smooth Muscle Contraction Negative Regulation Of Luteinizing Hormone Secretion Angiotensin-mediated Drinking Behavior Smooth Muscle Contraction Involved In Micturition Synaptic Transmission Behavior Response To Organic Substance Response To Stimulus Response To Alkaloid Regulation Of Acetylcholine Secretion, Neurotransmission Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Saliva Secretion Regulation Of Blood Pressure Regulation Of Cellular Process Prolactin Secretion Negative Regulation Of Gonadotropin Secretion Regulation Of Synaptic Transmission, Cholinergic Response To Leucine Regulation Of Saliva Secretion Micturition Response To Ozone Endosomal Transport
Tagcloud ?		04fmolt4 04mg 09mg 28ng 32ng 37g 58vo2ml 64g 71ng 94ng 99mg backgrounds bat carioca chf corticosterone ctrl d2 depot endocrine epididymal freezing glycemia impair kg0 retroperitoneal t4 triglycerides weights	bioinformatics cichlids dispersed fsh fxglm gonadotropin holds isoleucine lh luc neurokinin nh2 nkb nkbs nkf piscine pituitary possess possessing reproduction sre tac3r tac3ra tac3rb tachikinin tilapia tinkb tinkf valine
Tagcloud (Difference) ?		04fmolt4 04mg 09mg 28ng 32ng 37g 58vo2ml 64g 71ng 94ng 99mg backgrounds bat carioca chf corticosterone ctrl d2 depot endocrine epididymal freezing glycemia impair kg0 retroperitoneal t4 triglycerides weights	bioinformatics cichlids dispersed fsh fxglm gonadotropin holds isoleucine lh luc neurokinin nh2 nkb nkbs nkf piscine pituitary possess possessing reproduction sre tac3r tac3ra tac3rb tachikinin tilapia tinkb tinkf valine
Tagcloud (Intersection) ?