KIAA1377 and LPL

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KIAA1377	LPL
Gene Name		KIAA1377	lipoprotein lipase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome Midbody Ciliary Base	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Extracellular Matrix Anchored Component Of Membrane Very-low-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Lipoprotein Lipase Activity Phospholipase Activity Triglyceride Lipase Activity Receptor Binding Protein Binding Heparin Binding Triglyceride Binding Apolipoprotein Binding
	Biological Process	Mitotic Spindle Organization Cytoplasmic Microtubule Organization Cilium Assembly	Retinoid Metabolic Process Fatty Acid Biosynthetic Process Triglyceride Metabolic Process Phospholipid Metabolic Process Phototransduction, Visible Light Response To Cold Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Positive Regulation Of Sequestering Of Triglyceride Triglyceride Biosynthetic Process Triglyceride Catabolic Process Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Response To Drug Small Molecule Metabolic Process Triglyceride Homeostasis
Pathways			Lipoprotein metabolism Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Transcriptional regulation of white adipocyte differentiation Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport
Drugs			Tyloxapol
Diseases
GWAS			Cardiovascular disease risk factors ( 21943158) HDL cholesterol ( 23726366 20031538 21909109 18193043 18193044 20864672 19060906 19060911 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) Hematological and biochemical traits ( 20139978) Hyperactive-impulsive symptoms ( 18821565) Hypertriglyceridemia ( 23505323 20657596) Lipid metabolism phenotypes ( 22286219 19936222) Metabolic syndrome ( 22399527 21386085 20694148) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Triglycerides ( 23726366 21909109 18193043 18193044 18193046 20864672 19060906 19060911 22171074 20139978 17463246 20686565) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Waist circumference and related phenotypes ( 18454146)
Protein-Protein Interactions		86 interactors: AIMP2 AKTIP ARIH2 ATP6V1F ATRX BMI1 BRD1 C11orf58 CDKN2B CRCT1 CSTF2 DGCR6 DISC1 DLEU1 DNM1 DUSP12 DUSP23 EIF2S2 EIF6 EPN1 FAM118B FAM134A FEZ1 FGFR3 FXR1 GEMIN7 GET4 GIT1 GOLGB1 GPRASP2 GSTO1 HMOX2 HTT ING5 KAT5 KAT7 KIF15 KLHL20 LAMTOR5 LPL LRRC1 LUC7L2 MAD2L1BP MAPK9 MRPS6 NAP1L5 NAT9 NPM3 NSF NUDT21 ODF2L OFD1 PBK PDCD5 PFDN1 PIK3R3 PMF1 POLD1 POLR2M PPP1CA PPP1CC PRKRA PTPRS RAB27A RAN RBM23 RGS2 RIF1 ROGDI RPA2 RUVBL1 SAT1 SNRPG SPDL1 STAU2 TFG TNFRSF14 TNFSF11 TOMM20 TTR TXNDC9 VIM YAE1D1 YWHAZ ZBED8 ZNF24	16 interactors: APOC2 APP ASCC2 CALR CCND1 CETP COPS6 EMD KIAA1377 LRP1 LRP2 LUC7L2 PTPN4 RPL18A UBE2Z VLDLR
Entrez ID		57562	4023
HPRD ID		17212	01999
Ensembl ID		ENSG00000110318	ENSG00000175445
Uniprot IDs		Q9P2H0	P06858
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Cell Cycle Mitotic Cell Cycle Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Metabolic Process Mitotic Cell Cycle Process Cellular Process Response To Light Stimulus Response To Radiation Triglyceride Catabolic Process Gene Expression Positive Regulation Of Apoptotic Signaling Pathway Organelle Localization Acylglycerol Catabolic Process Endomembrane System Organization Establishment Of Organelle Localization Cell Cycle Process Positive Regulation Of Signal Transduction Peptidyl-lysine Modification Endosome Organization Protein Localization To Organelle Positive Regulation Of Metabolic Process Anatomical Structure Development System Development Regulation Of Signal Transduction Termination Of RNA Polymerase II Transcription Cytoplasmic Transport Programmed Cell Death Chromosome Organization Cell Division Ribosomal Subunit Export From Nucleus Cell Death Regulation Of Signaling Cellular Response To Stimulus Death Histone H3 Acetylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Ubiquitination Mitotic Nuclear Division Ribonucleoprotein Complex Biogenesis Response To Abiotic Stimulus Positive Regulation Of Striated Muscle Contraction Cellular Response To Organic Substance RNA Metabolic Process Organ Development Neurotransmitter Uptake	Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Response To Light Stimulus Regulation Of Cholesterol Transport Alcohol Metabolic Process Receptor-mediated Endocytosis Endocytosis Response To Radiation Regulation Of Plasma Lipoprotein Particle Levels Very-low-density Lipoprotein Particle Remodeling Phototransduction, Visible Light Retinoid Metabolic Process Triglyceride-rich Lipoprotein Particle Remodeling Diterpenoid Metabolic Process Detection Of Visible Light Regulation Of Lipid Transport Phototransduction Detection Of Light Stimulus Reverse Cholesterol Transport Isoprenoid Metabolic Process Regulation Of Cholesterol Efflux Lipid Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Metabolic Process Plasma Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Vesicle-mediated Transport Triglyceride Homeostasis Plasma Lipoprotein Particle Clearance Acylglycerol Homeostasis Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Response To Abiotic Stimulus Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Peptide Antigen Assembly With MHC Class I Protein Complex Beta-amyloid Clearance Positive Regulation Of Cell Cycle Cholesterol Transport Sterol Transport Lipid Transport Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Lipid Localization Cholesterol Homeostasis Sterol Homeostasis Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling
Tagcloud ?			8p21 apolipoprotein assigned atherosclerosis c5 c9 characterizing cli clones clusterin complement consider cosmid cytolytic determining glycoprotein isolating kb lipase lipoprotein nicked overlapping secreted seminal sertoli spans subchromosomal symbol translationally
Tagcloud (Difference) ?			8p21 apolipoprotein assigned atherosclerosis c5 c9 characterizing cli clones clusterin complement consider cosmid cytolytic determining glycoprotein isolating kb lipase lipoprotein nicked overlapping secreted seminal sertoli spans subchromosomal symbol translationally
Tagcloud (Intersection) ?