AARS2 and MEGF10

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		AARS2	MEGF10
Gene Name		alanyl-tRNA synthetase 2, mitochondrial	multiple EGF-like-domains 10
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion	Phagocytic Cup Integral Component Of Membrane Basolateral Plasma Membrane Cell Projection
	Molecular Function	TRNA Binding Alanine-tRNA Ligase Activity ATP Binding Zinc Ion Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Gene Expression Mitochondrial Respiratory Chain Complex Assembly Mitochondrial Alanyl-tRNA Aminoacylation	Skeletal Muscle Satellite Cell Activation Skeletal Muscle Satellite Cell Differentiation Skeletal Muscle Satellite Cell Proliferation Homotypic Cell-cell Adhesion Recognition Of Apoptotic Cell Regulation Of Skeletal Muscle Tissue Development Regulation Of Muscle Cell Differentiation Muscle Cell Development
Pathways		tRNA Aminoacylation Mitochondrial tRNA aminoacylation
Drugs
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		2 interactors: MEGF10 YWHAQ	22 interactors: AARS2 ALMS1 AP2M1 ARHGAP32 BAHD1 CADPS2 CEP57 CUL7 DHX16 GRB10 HDAC4 ITSN2 KIAA1598 MCF2L2 RANBP10 SART3 SCAPER SNRNP200 TAOK2 TMEM132A VWA8 ZNFX1
Entrez ID		57505	84466
HPRD ID		12397	14384
Ensembl ID		ENSG00000124608	ENSG00000145794
Uniprot IDs		Q5JTZ9	Q96KG7
PDB IDs
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Satellite Cell Proliferation Skeletal Muscle Satellite Cell Activation Skeletal Muscle Cell Proliferation Skeletal Muscle Satellite Cell Differentiation Recognition Of Apoptotic Cell Phagocytosis, Recognition Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Cell Clearance Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Substantia Nigra Development Neural Nucleus Development Positive Regulation Of Mitochondrion Organization Skeletal Muscle Cell Differentiation Regulation Of Skeletal Muscle Tissue Development Midbrain Development Regulation Of Mitochondrion Organization	Organelle Organization Cellular Component Assembly Positive Regulation Of Metabolic Process MRNA Splicing, Via Spliceosome Positive Regulation Of Histone Deubiquitination Mitochondrial Alanyl-tRNA Aminoacylation RNA Splicing, Via Transesterification Reactions Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Cellular Macromolecular Complex Assembly Regulation Of Generation Of Precursor Metabolites And Energy Cis Assembly Of Pre-catalytic Spliceosome
Tagcloud ?			adhere adopt ap2 ap50 associating autoimmunity ced cerebellum clathrin clearing coated colocalized corpses deeper dishes elucidating engulfment flat immunoblot irregular mirrored mosaic nematode ortholog pits stellate ubiquitinated unusually vacuoles
Tagcloud (Difference) ?			adhere adopt ap2 ap50 associating autoimmunity ced cerebellum clathrin clearing coated colocalized corpses deeper dishes elucidating engulfment flat immunoblot irregular mirrored mosaic nematode ortholog pits stellate ubiquitinated unusually vacuoles
Tagcloud (Intersection) ?