TRIM39 and PDLIM5

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TRIM39	PDLIM5
Gene Name		tripartite motif containing 39	PDZ and LIM domain 5
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol	Cytosol Postsynaptic Density Actin Cytoskeleton Membrane Z Disc Cell Junction Neuron Projection Postsynaptic Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Ligase Activity Identical Protein Binding	Actin Binding Protein Kinase C Binding Zinc Ion Binding Actinin Binding Protein N-terminus Binding
	Biological Process	Apoptotic Process Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Regulation Of Synapse Assembly Regulation Of Dendritic Spine Morphogenesis
Pathways
Drugs
Diseases
GWAS			Prostate cancer ( 19767753) Visceral fat ( 22589738)
Protein-Protein Interactions		52 interactors: APP CCNC DCUN1D1 DCX DIP2A EIF4A2 EPHB6 KDM1A LNX1 LXN MED18 MNAT1 OTUB2 OTUD6A PDLIM5 PLCD4 POLI PRPF3 PSMA6 PSMD9 RECK RNF166 SMCO3 TP53 TRIM17 TRIM21 TRIM8 TTC32 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBTD1 UBTD2 UBXN1 UBXN6 USP2 USP39 USP5 WDFY3 ZKSCAN4 ZNF26	13 interactors: ACTB ACTN1 CACNA1B CCDC136 COIL GFI1B KRT40 KRTAP10-7 PRKCB PRKCE PRKCG TRIM39 ZYX
Entrez ID		56658	10611
HPRD ID		09298	05799
Ensembl ID		ENSG00000204599	ENSG00000163110
Uniprot IDs		Q9HCM9	B7Z481 B7Z8X5 Q96HC4
PDB IDs		2DID 2DIF 2ECJ	2DAR 2UZC
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein Catabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Cellular Protein Metabolic Process Proteolysis Regulation Of Ubiquitin-protein Transferase Activity Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Metabolic Process Regulation Of Proteolysis Regulation Of Protein Ubiquitination Protein K63-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Toll-like Receptor 4 Signaling Pathway Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Toll-like Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cellular Response To Stress Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Activation Of Innate Immune Response	Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Pain Response To Morphine Immune Response-activating Cell Surface Receptor Signaling Pathway Activation Of Phospholipase C Activity Calcium Ion Transport Positive Regulation Of Phospholipase C Activity Cell-cell Signaling Actin Filament Bundle Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Phospholipase Activity Positive Regulation Of Cellular Glucuronidation Positive Regulation Of Mismatch Repair Regulation Of Phospholipase Activity Multicellular Organismal Response To Stress Adherens Junction Organization Positive Regulation Of Lipase Activity Response To Ammonium Ion Response To Stress Immune Response-regulating Signaling Pathway Immune System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Adhesion Negative Regulation Of Protein Ubiquitination Regulation Of Mismatch Repair TRAM-dependent Toll-like Receptor 4 Signaling Pathway Histone H3-T6 Phosphorylation Negative Regulation Of Protein Catabolic Process Cellular Response To Growth Factor Stimulus Synaptic Transmission Behavior Response To Growth Factor Chromatin Modification Response To Alkaloid Positive Regulation Of Immune Response Protein Localization To Tight Junction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway
Tagcloud ?		293t aeromonas aggregate b30 bloodthirsty btr18 btr20 btr21 btr22 danio deduced e3 gill hydrophila intestine ligase mentioned multigene nj rbcc remarkably rerio tripartite ubch6 ubiquitin ubiquitylated ubiquitylation zebrafish	14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pde6d ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2
Tagcloud (Difference) ?		293t aeromonas aggregate b30 bloodthirsty btr18 btr20 btr21 btr22 danio deduced e3 gill hydrophila intestine ligase mentioned multigene nj rbcc remarkably rerio tripartite ubch6 ubiquitin ubiquitylated ubiquitylation zebrafish	14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pde6d ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2
Tagcloud (Intersection) ?