PSEN1 and TCF7L2

Number of citations of the paper that reports this interaction (PMID 11504726)
7

Data Source:
HPRD (in vivo, in vitro)

		PSEN1	TCF7L2
Gene Name		presenilin 1	transcription factor 7-like 2 (T-cell specific, HMG-box)
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Kinetochore Nuclear Outer Membrane Mitochondrion Mitochondrial Inner Membrane Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Centrosome Integral Component Of Plasma Membrane Cell Cortex Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Z Disc Axon Growth Cone Cytoplasmic Vesicle Neuromuscular Junction Nuclear Membrane Ciliary Rootlet Neuronal Cell Body Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Gamma-secretase Complex	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm PML Body Protein-DNA Complex Beta-catenin-TCF7L2 Complex
	Molecular Function	Endopeptidase Activity Aspartic-type Endopeptidase Activity Calcium Channel Activity Protein Binding Beta-catenin Binding PDZ Domain Binding Cadherin Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding Nuclear Hormone Receptor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Gamma-catenin Binding Armadillo Repeat Domain Binding
	Biological Process	Autophagic Vacuole Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPKK Activity Blood Vessel Development Cell Fate Specification Somitogenesis Neuron Migration Positive Regulation Of Receptor Recycling Heart Looping Hematopoietic Progenitor Cell Differentiation T Cell Activation Involved In Immune Response Protein Glycosylation Membrane Protein Ectodomain Proteolysis Mitochondrial Transport Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Notch Signaling Pathway Notch Receptor Processing Memory Post-embryonic Development Protein Transport L-glutamate Transport Choline Transport Synaptic Vesicle Targeting Single Organismal Cell-cell Adhesion Protein Processing Cerebral Cortex Cell Migration Cajal-Retzius Cell Differentiation Dorsal/ventral Neural Tube Patterning Extracellular Matrix Disassembly Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Calcium Ion Homeostasis Beta-amyloid Formation Intracellular Signal Transduction Regulation Of Phosphorylation Amyloid Precursor Protein Catabolic Process Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Regulation Of Protein Binding Positive Regulation Of MAP Kinase Activity Negative Regulation Of Neuron Apoptotic Process Skin Morphogenesis Regulation Of Synaptic Plasticity Thymus Development Neuron Development Skeletal System Morphogenesis Brain Morphogenesis Beta-amyloid Metabolic Process Epithelial Cell Proliferation Negative Regulation Of Axonogenesis Positive Regulation Of Coagulation T Cell Receptor Signaling Pathway Neuron Apoptotic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Regulation Of Resting Membrane Potential Calcium Ion Transmembrane Transport Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Glycogen Metabolic Process Glucose Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Arrest Brain Development Cell Proliferation Cellular Response To Starvation Response To Glucose Post-embryonic Development Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Oligodendrocyte Development Neural Tube Development Pituitary Gland Development Bone Mineralization Negative Regulation Of BMP Signaling Pathway Embryonic Genitalia Morphogenesis Pancreas Development Regulation Of Myelination Positive Regulation Of Insulin Secretion Positive Regulation Of Protein Binding Secretory Granule Localization Regulation Of Hormone Metabolic Process Somatic Stem Cell Maintenance Multicellular Organism Growth Catenin Import Into Nucleus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Maintenance Of DNA Repeat Elements Skin Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Organ Growth Positive Regulation Of Protein Export From Nucleus Embryonic Digestive Tract Morphogenesis Embryonic Hindgut Morphogenesis Myoblast Fate Commitment Regulation Of Skeletal Muscle Tissue Development Regulation Of Smooth Muscle Cell Proliferation Generation Of Neurons Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Face Morphogenesis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Insulin Metabolic Process Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Degradation of the extracellular matrix	APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt binding of TCF/LEF:CTNNB1 to target gene promoters deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Peptide hormone metabolism Degradation of beta-catenin by the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Incretin synthesis, secretion, and inactivation truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes beta-catenin independent WNT signaling deletions in the AMER1 gene destabilize the destruction complex Ca2+ pathway AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Drugs
Diseases
GWAS			Breast cancer ( 23535729) Breast Cancer in BRCA1 mutation carriers ( 23544013) Coronary heart disease ( 21347282) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting insulin-related traits (interaction with BMI) ( 22581228) Glycated hemoglobin levels ( 20849430) Metabolic syndrome ( 20694148) Proinsulin levels ( 21873549) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 17668382 18372903 17293876 22693455 17554300 23300278 20581827 19401414 17463246 17463248 17463249 22101970 17460697 19056611 23209189) Type 2 diabetes and other traits ( 19734900)
Protein-Protein Interactions		91 interactors: ACTN1 AP1M2 APBA1 APH1A APH1B APOE APP BACE1 BCL2 BCL2L1 CASP1 CASP3 CASP4 CASP6 CASP7 CASP8 CDH1 CDK5 CFL1 CIB1 CTNNA1 CTNNB1 CTNND1 CTNND2 CYP2C18 CYP2C8 DLL1 DOCK3 DSP ECSIT EFHD1 EFNB2 ENSA EPB41L3 ERN1 ETFA FBXL12 FBXW7 FGF13 FLNA FLNB GAPDH GCDH GDI1 GFAP GSK3B HERPUD1 HMGB1 ICAM5 ITSN2 JUP KANK2 KCNIP3 KCNIP4 MAPT METTL2B MTCH1 NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OXCT1 PDCD4 PIK3R1 PKP4 PRAM1 PRDX2 PRKACA PRKCZ PSENEN PSMA5 PSMB1 RAB11A RAB3A RAD23A RHEB RMDN3 RNF32 SCAF11 SCN1A ST13 STAMBPL1 TCF4 TCF7L2 TDP2 TUBA1B UBQLN1 UMPS YME1L1	13 interactors: CSNK2A1 CSNK2A2 CTBP1 CTNNB1 CTNNBIP1 DAXX DAZAP2 EP300 FBLN1 JUP PSEN1 PSMA3 UBE2I
Entrez ID		5663	6934
HPRD ID		00087	03751
Ensembl ID		ENSG00000080815	ENSG00000148737
Uniprot IDs		P49768	B4DJZ2 B4DRJ8 B7Z9Z6 B9X074 C6ZRJ7 C6ZRJ8 C6ZRJ9 C6ZRK0 C6ZRK1 C6ZRK2 C6ZRK5 E2GH13 E2GH14 E2GH16 E2GH18 E2GH24 E2GH25 E2GH26 Q6FHW4 Q9NQB0
PDB IDs		2KR6	1JDH 1JPW 2GL7
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cell Death Regulation Of Apoptotic Process Cell Development Notch Receptor Processing Nervous System Development Generation Of Neurons Cell Differentiation Regulation Of Signaling Positive Regulation Of Cell Death Neurogenesis Positive Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death System Development Execution Phase Of Apoptosis Neuron Differentiation Anatomical Structure Development Multicellular Organismal Development Cellular Response To Stimulus Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Negative Regulation Of Cell Death Developmental Process Neuron Projection Development Negative Regulation Of Programmed Cell Death Neuron Development Signaling Response To Stimulus Regulation Of Signal Transduction Regulation Of Neurogenesis Regulation Of Cell Differentiation Cell Communication Regulation Of Protein Localization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Stress Regulation Of Establishment Of Protein Localization Notch Signaling Pathway Positive Regulation Of Proteolysis Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Development Cell Projection Organization Negative Regulation Of Cell Differentiation Positive Regulation Of Signal Transduction Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Localization	Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Viral Process Apoptotic Process Wnt Signaling Pathway Programmed Cell Death Cell Cycle Process Cell Death Death Regulation Of Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Process Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Mitotic Cell Cycle Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Cell Cycle Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process Cellular Response To Indole-3-methanol Regulation Of Chromosome Organization Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Anterior/posterior Pattern Specification Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Regulation Of Proteolysis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process
Tagcloud ?		1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy mapt neuropathological pd publically publication shifted tar variants	3a adenovirus bidirectional c57bl cat complexities consequence exploration foxo foxo1 gluconeogenesis gluconeogenic hepatic hepatocytes ltcfdn mechanistic opposing opposite pck1 picture preferential pyruvate redundant repressive suppressing views wnt
Tagcloud (Difference) ?		1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy mapt neuropathological pd publically publication shifted tar variants	3a adenovirus bidirectional c57bl cat complexities consequence exploration foxo foxo1 gluconeogenesis gluconeogenic hepatic hepatocytes ltcfdn mechanistic opposing opposite pck1 picture preferential pyruvate redundant repressive suppressing views wnt
Tagcloud (Intersection) ?