EIF2AK2 and MOV10

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		EIF2AK2	MOV10
Gene Name		eukaryotic translation initiation factor 2-alpha kinase 2	Mov10 RISC complex RNA helicase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm	Cytoplasmic MRNA Processing Body Extracellular Space Cytosol
	Molecular Function	Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Type 2A Regulator Activity Poly(A) RNA Binding	Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Activation Of MAPKK Activity Positive Regulation Of Cytokine Production Transcription, DNA-templated Translation Protein Phosphorylation Negative Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Translation Peptidyl-tyrosine Phosphorylation Modulation By Virus Of Host Morphology Or Physiology Modulation By Virus Of Host Process Viral Life Cycle Evasion Or Tolerance By Virus Of Host Immune Response Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Response To Interferon-alpha Negative Regulation Of Apoptotic Process Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway MRNA Cleavage Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling
Pathways		ISG15 antiviral mechanism Interferon Signaling Inhibition of PKR Cytokine Signaling in Immune system Host Interactions with Influenza Factors Influenza Infection NS1 Mediated Effects on Host Pathways Antiviral mechanism by IFN-stimulated genes	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Cellular Senescence Signaling by Wnt Signaling by EGFRvIII in Cancer Oncogene Induced Senescence Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR beta-catenin independent WNT signaling Signaling by ERBB2 Signaling by EGFR Ca2+ pathway Oxidative Stress Induced Senescence Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS			Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Hypertension ( 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		48 interactors: CASP3 CASP7 CASP8 CDC42 CHUK DHX30 DHX58 DHX9 DICER1 DNAJC3 EDC4 EIF2S1 EIF6 ELF2 FTSJ3 HIST2H2AC HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 MAP3K5 MAP3K7 METAP2 MOV10 NFKBIA NPM1 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PRKRIR PTGES3 RAC1 STAT1 STAT3 STRBP TAB2 TARBP2 TIRAP TOLLIP TP53 TYK2 ZNF346	1 interactors: EIF2AK2
Entrez ID		5610	4343
HPRD ID		01468	14732
Ensembl ID		ENSG00000055332	ENSG00000155363
Uniprot IDs		B7ZKK7 P19525 Q8IW76	Q5JR04 Q9H8T8 Q9HCE1
PDB IDs		1QU6 2A19 2A1A 3UIU
Enriched GO Terms of Interacting Partners?		Immune Response Defense Response Immune System Process Innate Immune Response Response To Stress Response To Organic Substance Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Response To Stimulus Regulation Of Cell Death Response To External Stimulus Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Stimulus Regulation Of Apoptotic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Fc Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Signal Transduction Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Posttranscriptional Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Response To Biotic Stimulus Response To Abiotic Stimulus Signaling Response To Growth Factor Response To Virus Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Metabolic Process Response To DsRNA Positive Regulation Of Intracellular Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway	Evasion Or Tolerance By Virus Of Host Immune Response Regulation Of Hematopoietic Stem Cell Differentiation Evasion Or Tolerance Of Host Defenses By Virus Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Regulation Of Hematopoietic Stem Cell Proliferation Response To Host Immune Response Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Osteoblast Proliferation Modulation By Virus Of Host Process Regulation Of Translation In Response To Stress Response To Interferon-alpha Modulation By Virus Of Host Morphology Or Physiology Regulation Of Osteoblast Proliferation Regulation Of Defense Response To Virus By Virus Negative Regulation Of Defense Response To Virus Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Chemokine Production Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Viral Genome Replication Regulation Of Chemokine Production Activation Of MAPKK Activity Regulation Of Viral Genome Replication Regulation Of Translational Initiation Negative Regulation Of Viral Process Regulation Of Defense Response To Virus Negative Regulation Of Translation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Interaction With Host ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Regulation Of Stem Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Unfolded Protein Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Viral Process Defense Response To Virus Response To Endoplasmic Reticulum Stress Regulation Of Stress-activated MAPK Cascade Viral Life Cycle Protein Autophosphorylation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Virus Activation Of Protein Kinase Activity Regulation Of Translation Peptidyl-tyrosine Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x	accompanied associates dissociation h3k27me3 hairpin helicase ink4a interacts locus lys27 mostly noncoding pcg polycomb prc1 precise prompting purifies putative reassessment repression repressive rna settings shrna silencing transcriptional trimethylation upregulation
Tagcloud (Difference) ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x	accompanied associates dissociation h3k27me3 hairpin helicase ink4a interacts locus lys27 mostly noncoding pcg polycomb prc1 precise prompting purifies putative reassessment repression repressive rna settings shrna silencing transcriptional trimethylation upregulation
Tagcloud (Intersection) ?