MAPK1 and MITF

Number of citations of the paper that reports this interaction (PMID 9440696)
91

Data Source:
HPRD (in vitro, in vivo)

		MAPK1	MITF
Gene Name		mitogen-activated protein kinase 1	microphthalmia-associated transcription factor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Early Endosome Late Endosome Golgi Apparatus Microtubule Organizing Center Cytosol Cytoskeleton Caveola Focal Adhesion Microtubule Cytoskeleton Axon Pseudopodium Dendrite Cytoplasm Perikaryon Protein Complex Extracellular Vesicular Exosome Mitotic Spindle	Nucleus Protein Complex
	Molecular Function	Phosphotyrosine Binding DNA Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Transcription Factor Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity Phosphatase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Dimerization Activity
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity MAPK Import Into Nucleus Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Apoptotic Process Chemotaxis Response To Stress Cellular Response To DNA Damage Stimulus Cell Cycle Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Synaptic Transmission Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Toxic Substance Organ Morphogenesis Positive Regulation Of Peptidyl-threonine Phosphorylation Viral Process Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sensory Perception Of Pain Cytosine Metabolic Process Platelet Activation Positive Regulation Of Cell Migration Regulation Of Protein Stability Lipopolysaccharide-mediated Signaling Pathway Regulation Of Stress-activated MAPK Cascade Mammary Gland Epithelial Cell Proliferation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Heat TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway ERBB Signaling Pathway Response To Exogenous DsRNA Response To Estrogen Innate Immune Response Negative Regulation Of Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Regulation Of Cytoskeleton Organization JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Labyrinthine Layer Blood Vessel Development ERK1 And ERK2 Cascade Response To Epidermal Growth Factor Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Regulation Of Cellular Response To Heat Regulation Of Early Endosome To Late Endosome Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Complex Assembly Osteoclast Differentiation Melanocyte Differentiation Regulation Of Cell Proliferation Camera-type Eye Development Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cell Fate Commitment Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Bone Remodeling
Pathways		phospho-PLA2 pathway Ca-dependent events Signaling by FGFR in disease Cellular Senescence ERKs are inactivated CREB phosphorylation through the activation of Ras Signaling by EGFRvIII in Cancer Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Fcgamma receptor (FCGR) dependent phagocytosis SHC-mediated signalling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Regulation of actin dynamics for phagocytic cup formation TRIF-mediated TLR3/TLR4 signaling Senescence-Associated Secretory Phenotype (SASP) Signaling by VEGF Signalling to RAS Downstream signal transduction Toll Like Receptor 3 (TLR3) Cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Frs2-mediated activation Transmission across Chemical Synapses Axon guidance IRS-mediated signalling L1CAM interactions Oncogene Induced Senescence VEGFA-VEGFR2 Pathway Activated TLR4 signalling VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling RSK activation Activation of NMDA receptor upon glutamate binding and postsynaptic events TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane NCAM signaling for neurite out-growth Signalling to p38 via RIT and RIN RAF/MAP kinase cascade Innate Immune System Signaling by Insulin receptor ERKs are inactivated Signal transduction by L1 Insulin receptor signalling cascade PLC beta mediated events IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events G-protein mediated events Signaling by FGFR Thrombin signalling through proteinase activated receptors (PARs) ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Signaling by GPCR Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization FCERI mediated MAPK activation Signaling by SCF-KIT SHC1 events in ERBB2 signaling DAP12 signaling Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions Opioid Signalling SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Signaling by Leptin Growth hormone receptor signaling Signalling to ERKs Prolonged ERK activation events ERK activation Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Recycling pathway of L1 M Phase Toll Like Receptor TLR6:TLR2 Cascade IRS-related events triggered by IGF1R Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Advanced glycosylation endproduct receptor signaling Post NMDA receptor activation events Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system Cellular response to heat stress Regulation of HSF1-mediated heat shock response NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer Cell Cycle, Mitotic ERK2 activation SHC1 events in EGFR signaling FRS2-mediated cascade IRS-mediated signalling Oxidative Stress Induced Senescence ERK2 activation Nuclear Events (kinase and transcription factor activation)
Drugs		Isoproterenol Arsenic trioxide Olomoucine Phosphonothreonine Purvalanol SB220025 N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE (3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088)
Protein-Protein Interactions		213 interactors: AR ARRB1 ARRB2 ATF2 ATP1A1 BCL2 BCL6 BRAF C1QBP CACYBP CAD CALCOCO1 CAPN2 CASP8 CASP9 CAV1 CD19 CDC25C CDT1 CDX2 CEBPB CEP55 CMTM3 CREBBP CRP CTSD CUEDC2 DAPK1 DUSP1 DUSP16 DUSP2 DUSP3 DUSP4 DUSP5 DUSP6 DUSP7 DUSP9 DYRK1B EGFR EGLN3 EIF4EBP1 ELK1 ENAH EP300 EPOR ERF ESR1 ESR2 ETS1 FCGR2B FHL3 FOS FOXO3 FRS2 FRS3 GAB1 GAB2 GABRR1 GAPDH GATA1 GATA2 GATA4 GJA1 GMFB GNPTAB GORASP2 GRB10 GRB2 GSK3B HDAC4 HIF1A HNF4A HSF1 HSF4 HSP90AA1 ID2 IER3 IFI35 IFNAR1 IQGAP1 IRS1 ITGB6 JUN JUND KARS KHDRBS1 KLF11 KRT8 KSR1 KSR2 LAMTOR3 LCK LIFR LIPE LRPAP1 MAFA MAP2K1 MAP2K2 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K10 MAPK14 MAPK8 MAPKAPK2 MAPKAPK5 MBP MCL1 METAP2 MITF MKNK1 MKNK2 MTIF3 MTPN MYB MYC NCOA1 NCOA3 NDE1 NEFH NEK2 NGFR NKX2-1 NOXA1 NR3C1 NR4A1 NR5A1 NTRK3 NUP153 PAK1 PAK2 PDE4D PEA15 PEBP1 PLAT PLCB1 PLK3 PPARA PPARG PPP1CA PPP1R9B PPP2CA PPP2R5B PPP2R5C PRKCD PRKCE PRKCZ PRPSAP1 PTPN1 PTPN5 PTPN7 PTPRE PTPRH PTPRR PXN RAF1 RB1 RET RGS19 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KB1 RPTOR RXRA SCNN1G SH2D1A SH2D3C SHANK3 SHC1 SLC9A1 SMAD1 SMAD2 SMAD3 SMAD4 SNCA SNCG SORBS3 SOS1 SP1 SREBF1 SREBF2 STAT3 STAT5A STAT5B SUPT20H TCF3 TFCP2 TGIF1 TH TIAL1 TNFRSF1A TNFRSF25 TNFSF11 TNIP1 TNIP2 TNKS2 TOB1 TOP2A TP53 TPR TSC2 TTN UBR5 UBTF VAV1 VDR YBX1 YBX3 ZC3HC1 ZFP36	28 interactors: APP CTNNB1 EBP EP300 FOS GSK3B HINT1 HK3 LEF1 MAPK1 MAPK14 MARK3 OTX2 PATZ1 PAX3 PAX6 PIAS1 PIAS2 PIAS3 PSMD14 RPS6KA1 SPI1 STUB1 SUMO1 TFE3 TFEB TFEC UBE2I
Entrez ID		5594	4286
HPRD ID		01496	01138
Ensembl ID		ENSG00000100030	ENSG00000187098
Uniprot IDs		P28482 Q1HBJ4 Q499G7	B4DNC7 O75030 Q8WYR3
PDB IDs		1PME 1TVO 1WZY 2OJG 2OJI 2OJJ 2Y9Q 3D42 3D44 3I5Z 3I60 3SA0 3TEI 3W55 4FMQ 4FUX 4FUY 4FV0 4FV1 4FV2 4FV3 4FV4 4FV5 4FV6 4FV7 4FV8 4FV9 4G6N 4G6O 4H3P 4H3Q 4IZ5 4IZ7 4IZA
Enriched GO Terms of Interacting Partners?		Response To Organic Substance Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To Stimulus Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signaling Regulation Of Signaling Cell Communication Response To Stimulus Signal Transduction Response To Stress Regulation Of Protein Metabolic Process Intracellular Signal Transduction Regulation Of Metabolic Process Response To Growth Factor Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Gene Expression Regulation Of Immune System Process Positive Regulation Of Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Defense Response Developmental Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Anatomical Structure Development Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Response To Hormone MAPK Cascade Apoptotic Process Immune System Process Regulation Of Cell Death Response To Abiotic Stimulus Cell Death Programmed Cell Death Death Signal Transduction By Phosphorylation Regulation Of Phosphorus Metabolic Process Organ Development	Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Immune System Process RNA Metabolic Process Nitrogen Compound Metabolic Process Protein Sumoylation Regulation Of Metabolic Process Apoptotic Process Peptidyl-lysine Modification Programmed Cell Death Immune Response Regulation Of Cellular Protein Metabolic Process Cell Death Death Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Peptidyl-amino Acid Modification Cellular Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Cellular Protein Modification Process Negative Regulation Of Biosynthetic Process Innate Immune Response Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Myeloid Cell Differentiation Biosynthetic Process Regulation Of Immune System Process Organ Development Negative Regulation Of Transcription, DNA-templated
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