PRKCD and PTPN22

Number of citations of the paper that reports this interaction (PMID 18056643)
42

Data Source:
HPRD (in vitro, in vivo)

		PRKCD	PTPN22
Gene Name		protein kinase C, delta	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Cell-cell Junction Nuclear Matrix Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-independent Protein Kinase C Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Enzyme Binding Insulin Receptor Substrate Binding Metal Ion Binding	Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding Kinase Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Cycle Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Gene Expression Regulation Of Receptor Activity Immunoglobulin Mediated Immune Response Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Termination Of Signal Transduction Platelet Activation Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Binding Interleukin-10 Production Interleukin-12 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Protein Dephosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis B Cell Proliferation Neutrophil Activation Defense Response To Bacterium Negative Regulation Of MAP Kinase Activity Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of Peptidyl-tyrosine Phosphorylation Protein Stabilization Negative Regulation Of Filopodium Assembly Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Platelet Aggregation Cellular Senescence Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway	Protein Dephosphorylation T Cell Differentiation Regulation Of Natural Killer Cell Proliferation Peptidyl-tyrosine Dephosphorylation Phosphoanandamide Dephosphorylation Regulation Of Innate Immune Response Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation
Pathways		Ca-dependent events Signaling by GPCR CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Interferon gamma signaling DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (z) signalling events Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF Calmodulin induced events Regulation of mRNA stability by proteins that bind AU-rich elements Apoptotic cleavage of cellular proteins DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Signaling by VEGF Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer Platelet activation, signaling and aggregation G alpha (q) signalling events HuR stabilizes mRNA DAG and IP3 signaling VEGFA-VEGFR2 Pathway CaM pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Programmed Cell Death Innate Immune System Signalling by NGF PLC beta mediated events Interferon Signaling Apoptotic execution phase Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PLC-gamma1 signalling
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Ulcerative colitis ( 23128233) Ventricular conduction ( 21076409)	Breast cancer ( 23535729) Crohn's disease ( 18587394 21102463 23128233) Hypothyroidism ( 22493691) Myasthenia gravis ( 23055271) Obesity-related traits ( 23251661) Rheumatoid arthritis ( 17804836 18794853 17554300 20453842 19503088) Type 1 diabetes ( 17632545 19430480 17554260 17554300 18978792) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 20410501)
Protein-Protein Interactions		118 interactors: ACTA1 ACTA2 ACTB ADAM9 ADCY7 ADD1 ADD2 ADRA2A ADRB2 ADRBK1 AFAP1 AKT3 APP ART3 BDKRB2 C1QBP CD34 CDCP1 CHAT CNP CREBBP CYTH1 DAB2 DYNC1H1 EEF1A1 EGFR EIF2S1 ELAVL1 EP300 ESRRA FLI1 FSCN1 FYN GABRA1 GAP43 GNA12 GNA13 GNAZ GNB2L1 GRM5 GSK3A HABP4 HDAC5 HIST1H1A HIST1H1B HNRNPK HSP90AA1 HSPA4 IGF1R IKBKB IL6ST INSR IRS1 ITGA6 ITGB2 ITGB4 ITGB7 ITPR1 KCNJ1 KCNJ4 KLF5 LCK LMNB1 LMNB2 LYN MACF1 MAPK1 MAPK3 MAPT MBP MEP1B MS4A2 MUC1 NCF1 NCF4 NFE2L2 NUMB OPRD1 PAK1 PDP1 PDP2 PDPK1 PEBP1 PIK3CA PIK3CB PLCB1 PLD2 PLSCR1 PLSCR3 PPARA PPM1A PPP1CA PPP2CA PPP2R5C PRKCZ PRKDC PTK2B PTPN22 PTPN6 PTPRA RAC1 RAF1 RASGRP3 RIPK4 RUNX2 SDC4 SHC1 SRC STAT1 STAT3 TAGLN TIAM1 TNFRSF1A VCP VHL YWHAB YWHAG YWHAZ	9 interactors: CBL CD247 CD3E CSK GRB2 LCK PRKCD VAV1 ZAP70
Entrez ID		5580	26191
HPRD ID		01501	06100
Ensembl ID		ENSG00000163932	ENSG00000134242
Uniprot IDs		Q05655	B4DZW8 Q9Y2R2
PDB IDs		1YRK 2YUU	2P6X 2QCJ 2QCT 3BRH 3H2X 3OLR 3OMH 4J51
Enriched GO Terms of Interacting Partners?		Signaling Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Metabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Peptide Cellular Response To Stimulus Cellular Response To Peptide Hormone Stimulus Defense Response Response To Stress Cellular Response To Organonitrogen Compound Response To Stimulus Platelet Activation Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Immune System Process Positive Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Response To Peptide Response To Hormone Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Innate Immune Response Regulation Of Signaling Response To Peptide Hormone Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Growth Factor Wound Healing Cell Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Hemostasis Positive Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Protein Modification Process Anatomical Structure Development Positive Regulation Of Protein Phosphorylation Cellular Response To Insulin Stimulus Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Fc Receptor Signaling Pathway Immune Response Response To Insulin	Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell Adhesion Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process T Cell Receptor Signaling Pathway Cell Activation Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Innate Immune Response Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Immune System Process Immune Response Defense Response Lymphocyte Activation Blood Coagulation Hemostasis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Signal Transduction Peptidyl-tyrosine Autophosphorylation Leukocyte Activation Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Leukocyte Migration
Tagcloud ?		alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	aitd antigens autoimmunity breakdown cd28 cd40 ctla4 develops discrepancy fcrl3 happen hashimoto humoral hyperthyroidism hypothyroidism il2ra immunogenicity immunoregulatory infiltrating insults iodine multifactorial parity preponderance thymus thyroglobulin thyroid thyrotropin wrong
Tagcloud (Difference) ?		alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	aitd antigens autoimmunity breakdown cd28 cd40 ctla4 develops discrepancy fcrl3 happen hashimoto humoral hyperthyroidism hypothyroidism il2ra immunogenicity immunoregulatory infiltrating insults iodine multifactorial parity preponderance thymus thyroglobulin thyroid thyrotropin wrong
Tagcloud (Intersection) ?