PPM1A and CACNA1B

Number of citations of the paper that reports this interaction (PMID 15728831)
6

Data Source:
HPRD (in vitro, in vivo)

		PPM1A	CACNA1B
Gene Name		protein phosphatase, Mg2+/Mn2+ dependent, 1A	calcium channel, voltage-dependent, N type, alpha 1B subunit
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Voltage-gated Calcium Channel Complex Membrane Neuron Projection	Plasma Membrane Voltage-gated Calcium Channel Complex Dendrite Neuronal Cell Body
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Signal Transducer Activity Protein Binding Protein C-terminus Binding Manganese Ion Binding Calmodulin-dependent Protein Phosphatase Activity R-SMAD Binding	Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding Protein C-terminus Binding High Voltage-gated Calcium Channel Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Dephosphorylation N-terminal Protein Myristoylation Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Gene Expression Negative Regulation Of SMAD Protein Complex Assembly Wnt Signaling Pathway Dephosphorylation Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-threonine Dephosphorylation Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated	Transport Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Regulation Of Heart Contraction Regulation Of Blood Pressure Regulation Of Ion Transmembrane Transport Response To Pain Membrane Depolarization Regulation Of Calcium Ion Transport Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential
Pathways		Loss of Function of TGFBR2 in Cancer IRS-mediated signalling mTOR signalling SMAD2/3 MH2 Domain Mutants in Cancer mTOR signalling TGFBR1 LBD Mutants in Cancer IGF1R signaling cascade Downregulation of SMAD2/3:SMAD4 transcriptional activity Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRS-related events triggered by IGF1R Generic Transcription Pathway Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor TGFBR2 MSI Frameshift Mutants in Cancer Insulin receptor signalling cascade SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Regulation of AMPK activity via LKB1 TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer IRS-related events Loss of Function of TGFBR1 in Cancer IRS-mediated signalling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade SMAD4 MH2 Domain Mutants in Cancer	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Allergic rhinitis ( 22036096)
Protein-Protein Interactions		19 interactors: AKT1 CACNA1A CACNA1B CACNA1C CTNNB1 DVL1 DVL2 DVL3 EEF2 FGFR2 GRM3 HSPB1 MSN NR4A1 PIK3R1 PRKCD RPLP0 SMAD2 SMAD3	9 interactors: APBA1 CACNB3 GNAO1 GNB1 PDLIM5 PPM1A RGS12 RIMS1 RXRB
Entrez ID		5494	774
HPRD ID		16199	03005
Ensembl ID		ENSG00000100614	ENSG00000148408
Uniprot IDs		B2R8E4 P35813	B1AQK4 B1AQK7 Q00975
PDB IDs		1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO	2LCM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Canonical Wnt Signaling Pathway Embryonic Organ Development Intracellular Signal Transduction Positive Regulation Of Wnt Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Embryonic Organ Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cardiovascular System Development Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Death Posttranscriptional Regulation Of Gene Expression Signaling Negative Regulation Of Signal Transduction Cell Communication Heart Development Negative Regulation Of Cellular Metabolic Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Planar Cell Polarity Pathway Involved In Neural Tube Closure Neural Plate Development Digestive Tract Morphogenesis Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Embryonic Foregut Morphogenesis Positive Regulation Of Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Foregut Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell-cell Signaling Regulation Of Organ Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Organ Development Response To Fibroblast Growth Factor Embryonic Morphogenesis Regulation Of Catalytic Activity	Glutamate Secretion Synaptic Transmission Dopamine Receptor Signaling Pathway Signaling Cell Communication Acid Secretion Cell-cell Signaling Dicarboxylic Acid Transport Membrane Depolarization Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Hormone Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Gamma-aminobutyric Acid Secretion System Development Amino Acid Transport Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of SMAD Protein Complex Assembly Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Cellular Response To Acid Chemical Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Calcium Ion Transport Cardiac Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Response To Organonitrogen Compound Multicellular Organismal Development DNA-templated Transcription, Initiation Calcium Ion-dependent Exocytosis Of Neurotransmitter N-terminal Protein Myristoylation Locomotory Behavior Gamma-aminobutyric Acid Transport Protein Myristoylation Anatomical Structure Development Response To Organic Cyclic Compound Response To Hormone Regulation Of Membrane Potential Positive Regulation Of Metabolic Process Peptidyl-threonine Dephosphorylation Signal Transduction Cellular Response To Prostaglandin E Stimulus Regulation Of Inhibitory Postsynaptic Membrane Potential G-protein Coupled Acetylcholine Receptor Signaling Pathway Carboxylic Acid Transport Organic Acid Transport Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Developmental Process Negative Regulation Of NF-kappaB Import Into Nucleus Nervous System Development Cellular Response To Prostaglandin Stimulus
Tagcloud ?		agt card4 casp1 csf2 csf3 curcuma f2r icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10	annealed arguably asd autism bd bipolar candidates chip cnvs disparate fgfr1 glycogen gsk3beta gwass incorporated investigators lithium microarrays nrng pathophysiology pcdh9 phosphoinositide revolving salts searches seemingly shortcomings snap29 sz
Tagcloud (Difference) ?		agt card4 casp1 csf2 csf3 curcuma f2r icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10	annealed arguably asd autism bd bipolar candidates chip cnvs disparate fgfr1 glycogen gsk3beta gwass incorporated investigators lithium microarrays nrng pathophysiology pcdh9 phosphoinositide revolving salts searches seemingly shortcomings snap29 sz
Tagcloud (Intersection) ?