KLHDC4 and SUV39H2

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		KLHDC4	SUV39H2
Gene Name		kelch domain containing 4	suppressor of variegation 3-9 homolog 2 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Chromosome, Centromeric Region Chromatin Nucleoplasm Nuclear Heterochromatin
	Molecular Function	Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K9 Specific)
	Biological Process		Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Assembly Or Disassembly Chromatin Remodeling Transcription, DNA-templated Male Meiosis Cell Differentiation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia
Pathways			Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CEP76 KDM1A SUV39H1 SUV39H2 TERF1	39 interactors: AKAP9 APPL2 BLZF1 C8orf74 CBX5 CBX7 CCDC151 CCDC37 CDCA4 CEP70 CGGBP1 EWSR1 FAM20C GSTCD ID2 KCTD17 KLF3 KLHDC4 LCA5L LNX1 LRIF1 MCM3AP MRFAP1 MTF2 MYL12A NME4 PHF19 PNMA1 POLR3F RAB3IP RASSF1 SHC1 SMAD5 SNF8 UBE2V2 WIZ ZNF212 ZNF557 ZNF57
Entrez ID		54758	79723
HPRD ID		11180	07580
Ensembl ID		ENSG00000104731	ENSG00000152455
Uniprot IDs		Q8TBB5	Q9H5I1
PDB IDs			2R3A
Enriched GO Terms of Interacting Partners?		Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Peptidyl-lysine Dimethylation Chromatin Modification Chromatin Organization Negative Regulation Of Circadian Rhythm Histone H3-K9 Methylation Peptidyl-lysine Trimethylation Chromosome Organization Histone H3-K9 Modification Histone Modification Organelle Organization Negative Regulation Of Biosynthetic Process Cell Cycle Negative Regulation Of Chromosome Organization Histone Lysine Methylation Regulation Of Circadian Rhythm Peptidyl-lysine Methylation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Primitive Erythrocyte Differentiation Cellular Response To Oxygen Levels G2/M Transition Of Mitotic Cell Cycle Histone Methylation Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Microtubule-based Process Regulation Of Organelle Organization Protein Methylation Telomeric Loop Formation Age-dependent Telomere Shortening Regulation Of Chromosome Organization Telomere Maintenance Via Telomere Shortening Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Peptidyl-lysine Modification Negative Regulation Of Telomere Maintenance Via Telomerase Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Response To Hypoxia Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Negative Regulation Of Gene Expression Rhythmic Process Replicative Cell Aging Positive Regulation Of Megakaryocyte Differentiation	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Cellular Process Positive Regulation Of Histone H3-K27 Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Histone H3-K27 Methylation Regulation Of RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Osteoblast Differentiation Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Golgi To Plasma Membrane Transport Positive Regulation Of Histone Methylation Nitrogen Compound Metabolic Process Positive Regulation Of DNA Metabolic Process Osteoclast Maturation Regulation Of Histone Methylation Regulation Of Ossification Protein Targeting Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process Establishment Of Protein Localization To Membrane Positive Regulation Of DNA Replication Positive Regulation Of Histone Modification Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Osteoblast Differentiation Myeloid Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Protein Localization To Plasma Membrane Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition
Tagcloud ?			a7 circular dichroism dim g12 g13 g9a h3k9 h3k9me0 h3k9me1 h3k9me2 h3k9me3 introduce introduces k14 labrador n324k pkmts prefers processive r8 readout recognizes renders retrievers s10 t11 t6
Tagcloud (Difference) ?			a7 circular dichroism dim g12 g13 g9a h3k9 h3k9me0 h3k9me1 h3k9me2 h3k9me3 introduce introduces k14 labrador n324k pkmts prefers processive r8 readout recognizes renders retrievers s10 t11 t6
Tagcloud (Intersection) ?