PPARD and PEBP1

Number of citations of the paper that reports this interaction (PMID 15001550)
7

Data Source:
HPRD (in vitro)

		PPARD	PEBP1
Gene Name		peroxisome proliferator-activated receptor delta	phosphatidylethanolamine binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Drug Binding Zinc Ion Binding Lipid Binding Sequence-specific DNA Binding NF-kappaB Binding Linoleic Acid Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Phosphatidylethanolamine Binding Enzyme Binding Protein Kinase Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Glucose Metabolic Process Proteoglycan Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Fatty Acid Beta-oxidation Vitamin A Metabolic Process Heart Development Embryo Implantation Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cell Proliferation Axon Ensheathment Phospholipid Biosynthetic Process Fatty Acid Catabolic Process MRNA Transcription Response To Glucose Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Negative Regulation Of Smooth Muscle Cell Migration Glucose Transport Fatty Acid Transport Cell Differentiation Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Cell-substrate Adhesion Positive Regulation Of Insulin Secretion Negative Regulation Of Collagen Biosynthetic Process Response To Vitamin A Wound Healing Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Keratinocyte Proliferation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Epidermis Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Decidualization Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Keratinocyte Migration Adipose Tissue Development Cellular Response To Hypoxia Apoptotic Signaling Pathway	Negative Regulation Of Endopeptidase Activity
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Signaling by Retinoic Acid Import of palmitoyl-CoA into the mitochondrial matrix Pyruvate metabolism and Citric Acid (TCA) cycle Nuclear Receptor transcription pathway The citric acid (TCA) cycle and respiratory electron transport
Drugs		Icosapent Treprostinil Sulindac Bezafibrate Heptyl-Beta-D-Glucopyranoside (11E)-OCTADEC-11-ENOIC ACID (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid
Diseases
GWAS		Cataracts in type 2 diabetes ( 23137000) Height ( 21998595) Pulmonary function (interaction) ( 23284291) Response to antipsychotic treatment ( 20195266)
Protein-Protein Interactions		39 interactors: BCL6 CEP350 DUT EIF3I EP300 GADD45B GADD45G GLUL HDAC1 HDAC2 HDAC3 HDAC4 HDAC7 HSP90AA1 ITGB5 KDM1A KRTAP10-3 KRTAP10-7 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR0B2 NRIP1 PEBP1 PPARGC1A PRDX6 PRMT3 PROX1 RANBP9 RXRA RXRB RXRG SHMT2 SMAD9 SPEN SRC TNP1	20 interactors: ADRBK1 CACHD1 CHUK GSDMB IKBKB MAP2K1 MAP3K14 MAP3K7 MAPK1 MED10 NKX3-1 NR2C2 PPARD PRKCA PRKCB PRKCD PRKCG PRKCZ RAF1 STC2
Entrez ID		5467	5037
HPRD ID		02679	06850
Ensembl ID		ENSG00000112033	ENSG00000089220
Uniprot IDs		F1D8S7 Q03181	B4DRT4 D9IAI1 P30086
PDB IDs		1GWX 1Y0S 2AWH 2B50 2BAW 2ENV 2GWX 2J14 2Q5G 2XYJ 2XYW 2XYX 2ZNP 2ZNQ 3D5F 3DY6 3ET2 3GWX 3GZ9 3OZ0 3PEQ 3SP9 3TKM	1BD9 1BEH 2L7W 2QYQ
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Rhythmic Process Chromatin Organization Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Modification Positive Regulation Of Metabolic Process Circadian Rhythm Response To Organic Substance Histone Modification Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Gene Expression Regulation Of Transcription, DNA-templated Histone H4 Deacetylation Multicellular Organismal Development Cellular Response To Organic Substance Organelle Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Developmental Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Histone H3 Deacetylation	Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Fibroblast Growth Factor Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Phosphorylation Intracellular Signal Transduction Platelet Activation Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-threonine Phosphorylation Positive Regulation Of Immune System Process Toll-like Receptor 5 Signaling Pathway Regulation Of Signal Transduction Response To Stress Immune Response Regulation Of Immune System Process Toll-like Receptor 10 Signaling Pathway Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Defense Response Phosphate-containing Compound Metabolic Process Toll-like Receptor 2 Signaling Pathway Fc Receptor Signaling Pathway Toll-like Receptor 9 Signaling Pathway Response To Wounding Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Protein Kinase Activity Activation Of MAPKK Activity MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Toll-like Receptor 3 Signaling Pathway Regulation Of Signaling
Tagcloud ?		almendro birc5 casein catenin cd44 deregulate distinguished dvl1 ffpe fzd7 gonen ly294002 martins mimicking mmp7 modulators notch1 pam50 park pten readout subpopulation sulfide sulindac tnbc wp xav939 zymograph	aspects bio blotting cytoskeleton differentially dimensional downregulated downregulation electrophoresis eleven elucidate expressions gastric gastritis gel matched mucosa neuropolypeptide oxidation phosphatidylethanolamine preliminarily rt ten thioredoxin txndc5 upregulated upregulation validated varioliform
Tagcloud (Difference) ?		almendro birc5 casein catenin cd44 deregulate distinguished dvl1 ffpe fzd7 gonen ly294002 martins mimicking mmp7 modulators notch1 pam50 park pten readout subpopulation sulfide sulindac tnbc wp xav939 zymograph	aspects bio blotting cytoskeleton differentially dimensional downregulated downregulation electrophoresis eleven elucidate expressions gastric gastritis gel matched mucosa neuropolypeptide oxidation phosphatidylethanolamine preliminarily rt ten thioredoxin txndc5 upregulated upregulation validated varioliform
Tagcloud (Intersection) ?