PPARA and AKAP13

Number of citations of the paper that reports this interaction (PMID 9627117)
24

Data Source:
HPRD (in vivo, in vitro)

		PPARA	AKAP13
Gene Name		peroxisome proliferator-activated receptor alpha	A kinase (PRKA) anchor protein 13
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Drug Binding Zinc Ion Binding Lipid Binding Phosphatase Binding Protein Domain Specific Binding Ubiquitin Conjugating Enzyme Binding Protein Complex Binding Sequence-specific DNA Binding NFAT Protein Binding MDM2/MDM4 Family Protein Binding	CAMP-dependent Protein Kinase Activity Signal Transducer Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Rho GTPase Binding Protein Complex Scaffold Metal Ion Binding Protein Kinase A Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Fatty Acid Metabolic Process Heart Development Circadian Rhythm Epidermis Development Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Cholesterol Storage Negative Regulation Of Sequestering Of Triglyceride Fatty Acid Transport Intracellular Receptor Signaling Pathway Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Protein Binding Negative Regulation Of Appetite Response To Insulin Circadian Regulation Of Gene Expression Behavioral Response To Nicotine Wound Healing Lipoprotein Metabolic Process Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fatty Acid Oxidation Enamel Mineralization Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Neuron Death Negative Regulation Of Transcription Regulatory Region DNA Binding	Protein Phosphorylation Small GTPase Mediated Signal Transduction Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Nuclear Export Apoptotic Signaling Pathway Regulation Of Glucocorticoid Mediated Signaling Pathway
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Nuclear Receptor transcription pathway REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters	Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs		Clofibrate Fenofibrate Gemfibrozil Bezafibrate Deoxy-Bigchap 2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid ALEGLITAZAR
Diseases
GWAS			Central corneal thickness ( 20719862) Corneal structure ( 23291589)
Protein-Protein Interactions		44 interactors: AIP AKAP13 CDK3 CEP350 CHD9 DAP3 DUT EP300 FABP1 FOXA3 GADD45A GADD45B GADD45G HELZ2 HSP90AA1 MAPK1 MAPK3 MECR MED1 MED24 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR1H3 NRBF2 NRIP1 POU1F1 PPARGC1A PPARGC1B PRKCA PRKCD PRMT1 PRMT8 RELA RXRA RXRG SIRT1 SRC STAC3 SUMO1 TNP1 UBE2I	20 interactors: CTNNAL1 DYT10 ESR1 ESR2 GNA12 GNAQ MAP1LC3A PPARA PRKACA PRKAR2A PRKD1 RANBP2 RHOA RTKN RXRB THRA YWHAB YWHAE YWHAG YWHAZ
Entrez ID		5465	11214
HPRD ID		01369	05253
Ensembl ID		ENSG00000186951	ENSG00000170776
Uniprot IDs		F1D8S4 Q07869	B0AZU4 Q12802
PDB IDs		1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR	2DRN 2LG1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Transcription, DNA-templated Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Response To Hormone DNA-templated Transcription, Initiation Organelle Organization Regulation Of Gene Expression Cellular Response To Organic Substance Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Chromatin Modification Negative Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Response To Organic Substance Peptidyl-amino Acid Modification Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Androgen Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Regulation Of Signaling Signal Transduction Response To Steroid Hormone Negative Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Cell Communication Nucleobase-containing Compound Metabolic Process	Cell Communication Signal Transduction Cellular Response To Stimulus Cellular Response To Organic Substance Signaling Cellular Response To Hormone Stimulus Regulation Of Intracellular Transport Regulation Of Establishment Of Protein Localization Response To Stimulus Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Protein Localization Response To Organic Substance Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Steroid Hormone Mediated Signaling Pathway Response To Hormone Positive Regulation Of Intracellular Transport Intracellular Signal Transduction Regulation Of Cellular Localization Hormone-mediated Signaling Pathway Positive Regulation Of Phospholipase C Activity Rho Protein Signal Transduction Positive Regulation Of Mitochondrion Organization Transcription Initiation From RNA Polymerase II Promoter Apoptotic Signaling Pathway Cellular Response To Steroid Hormone Stimulus Wound Healing Intrinsic Apoptotic Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Platelet Activation Apoptotic Process Cellular Response To Organic Cyclic Compound Regulation Of Signaling Programmed Cell Death Positive Regulation Of Organelle Organization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Phospholipase Activity Response To Wounding Positive Regulation Of Lipase Activity Ras Protein Signal Transduction Blood Coagulation Cell Death Death Neurotrophin Signaling Pathway Hemostasis DNA-templated Transcription, Initiation Regulation Of Mitochondrion Organization Negative Regulation Of Kinase Activity
Tagcloud ?		abca1 alfalfa aragonesa breed concentrate contrary dams finishing grazed grazing indoors lambs lengths lpl lt pparg rasa scarb1 sf slaughtering srebp1 subcutaneous supplemented thoracis tocopherol tocopheryl ve10d ve20d ve30d	anchoring assume bifunctional bundle causation chair crisis dbl deregulated dh dynamical explains gdp gef gtpase guanine helical hyperactive lbc linker mediation onco pleckstrin possessing rhoa rigid scattering seat solitary
Tagcloud (Difference) ?		abca1 alfalfa aragonesa breed concentrate contrary dams finishing grazed grazing indoors lambs lengths lpl lt pparg rasa scarb1 sf slaughtering srebp1 subcutaneous supplemented thoracis tocopherol tocopheryl ve10d ve20d ve30d	anchoring assume bifunctional bundle causation chair crisis dbl deregulated dh dynamical explains gdp gef gtpase guanine helical hyperactive lbc linker mediation onco pleckstrin possessing rhoa rigid scattering seat solitary
Tagcloud (Intersection) ?