ATR and PTS

Number of citations of the paper that reports this interaction (PMID 10608806)
171

Data Source:
BioGRID (unspecified method)

		ATR	PTS
Gene Name		ATR serine/threonine kinase	6-pyruvoyltetrahydropterin synthase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	XY Body Nucleoplasm Chromosome Golgi Apparatus PML Body	Cytoplasm Mitochondrion Cytosol
	Molecular Function	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MutLalpha Complex Binding MutSalpha Complex Binding Protein Dimerization Activity	6-pyruvoyltetrahydropterin Synthase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Cell Cycle Multicellular Organismal Development Negative Regulation Of DNA Replication Peptidyl-serine Phosphorylation Cellular Response To Heat Cellular Response To UV Response To Drug Regulation Of Protein Binding Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Cellular Response To Gamma Radiation Replicative Senescence Regulation Of Cellular Response To Heat	Cellular Amino Acid Metabolic Process Tetrahydrobiopterin Biosynthetic Process Central Nervous System Development Small Molecule Metabolic Process Nitric Oxide Metabolic Process Regulation Of Nitric-oxide Synthase Activity
Pathways		Fanconi Anemia pathway G2/M DNA damage checkpoint G2/M Checkpoints Meiotic synapsis Regulation of HSF1-mediated heat shock response Cellular response to heat stress Regulation of the Fanconi anemia pathway Activation of ATR in response to replication stress Cell Cycle Checkpoints	Metabolism of nitric oxide eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: AATF ABL1 AP1B1 AP2A2 ARHGEF1 ATM ATRIP BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CLSPN CREB1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 FANCA FANCD2 FLT1 H2AFX KDR LIG4 MCM2 MRE11A MSH2 NBN PA2G4 PIK3CA POLD1 POLN PPP2R2A PTS RAD17 RHEB TP53 TREX1 UPF1 VPRBP XPA XRCC5	12 interactors: ATM ATR COIL FNDC5 FXR2 LNX1 PBRM1 PRKDC PRKG2 SDCBP THAP10 WDYHV1
Entrez ID		545	5805
HPRD ID		08369	11840
Ensembl ID		ENSG00000175054	ENSG00000150787
Uniprot IDs		Q13535	Q03393
PDB IDs			3I2B
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Cell Cycle Process Cell Cycle DNA Damage Checkpoint Double-strand Break Repair DNA Replication Cell Cycle Checkpoint DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Regulation Of Cell Cycle Response To Ionizing Radiation Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle G2 DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Stimulus Intrinsic Apoptotic Signaling Pathway Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Response To Abiotic Stimulus Apoptotic Signaling Pathway Double-strand Break Repair Via Homologous Recombination Recombinational Repair Organelle Organization Response To Stimulus Cell Cycle Arrest Negative Regulation Of DNA Metabolic Process Response To X-ray Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Checkpoint Signal Transduction By P53 Class Mediator Telomere Maintenance Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Replication B Cell Activation Signal Transduction In Response To DNA Damage Biosynthetic Process	Peptidyl-serine Phosphorylation Response To Gamma Radiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Replicative Senescence Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Signal Transduction By P53 Class Mediator Response To Ionizing Radiation DNA Damage Checkpoint Double-strand Break Repair Cellular Response To Gamma Radiation V(D)J Recombination Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cellular Response To Heat Protein Autophosphorylation Cell Cycle Checkpoint DNA Recombination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Cellular Protein Metabolic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Cellular Response To Ionizing Radiation Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To Heat Negative Regulation Of Protein Metabolic Process Positive Regulation Of Response To DNA Damage Stimulus Cell Aging Telomere Maintenance Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Peptidyl-amino Acid Modification Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Somitogenesis Cell Cycle Process Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Radiation Somite Development Mitotic DNA Damage Checkpoint Cellular Protein Modification Process Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle B Cell Differentiation Response To Heat Segmentation Heart Development Regulation Of Response To DNA Damage Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition
Tagcloud ?		activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp	achieve aida apl atra became chemotherapy consolidation converting courses cytogenetic fab gimema hematologic interpretation lap0493 m3 majority molecularly morphologic mths myelogenous persistence promyelocytic q12 q22 remission successive transcript validity
Tagcloud (Difference) ?		activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp	achieve aida apl atra became chemotherapy consolidation converting courses cytogenetic fab gimema hematologic interpretation lap0493 m3 majority molecularly morphologic mths myelogenous persistence promyelocytic q12 q22 remission successive transcript validity
Tagcloud (Intersection) ?