TERF2IP and PAFAH1B3

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		TERF2IP	PAFAH1B3
Gene Name		telomeric repeat binding factor 2, interacting protein	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mre11 Complex	Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Telomeric DNA Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Binding Protein Heterodimerization Activity Platelet-activating Factor Acetyltransferase Activity
	Biological Process	Telomere Maintenance Transcription, DNA-templated Regulation Of Transcription, DNA-templated Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Protection From Non-homologous End Joining At Telomere Negative Regulation Of Telomere Maintenance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region	Lipid Metabolic Process Spermatogenesis Nervous System Development Brain Development Lipid Catabolic Process
Pathways		Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS
Protein-Protein Interactions		125 interactors: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 C9orf78 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DHX38 DNMT3A DPP3 ENAH EPAS1 EPS8L1 FABP2 FAM122A GAGE5 GAMT GNMT GPKOW HAAO HAGH HDGFRP3 HIST1H1A HIST1H2AL HIST1H4B HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NUDT14 NUDT18 NUMA1 NXNL1 OCM2 OGFR PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PML PNMT POLD1 PPM1G PPP1R2 PPP6R3 PRDX6 PRX PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SMARCC2 SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 XRCC6 ZNF146 ZNF414	33 interactors: BRD7 C14orf1 CCDC90B CHMP7 COPS6 CRMP1 DDX24 ECH1 EEF1A1 GAPDH GBP2 GDF9 HSPH1 IGSF21 LNX1 LRIF1 MED31 PAFAH1B1 PAFAH1B2 PLEKHM1 RBM48 SDCBP2 SETDB1 SUMO4 TERF1 TERF2IP TLE1 TP53 TUBB2A UNC119 XRCC6 ZBTB16 ZHX1
Entrez ID		54386	5050
HPRD ID		05452	04354
Ensembl ID		ENSG00000166848	ENSG00000079462
Uniprot IDs		Q9NYB0	Q15102
PDB IDs		1FEX 3K6G
Enriched GO Terms of Interacting Partners?		Chromosome Organization Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Organelle Organization Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process DNA Conformation Change Chromatin Modification Cell Cycle Cellular Response To Stress DNA Metabolic Process Cellular Response To DNA Damage Stimulus Sequestering Of Actin Monomers DNA Recombination Telomere Maintenance Via Telomere Lengthening Catabolic Process DNA Duplex Unwinding Cellular Aldehyde Metabolic Process Cellular Hyperosmotic Salinity Response DNA Geometric Change DNA Replication Energy Reserve Metabolic Process Nucleosome Organization Organophosphate Catabolic Process Response To Stress Chromatin Assembly Or Disassembly Deoxyribose Phosphate Catabolic Process Cellular Localization Cellular Metabolic Process Protein Localization To Nucleus Glycogen Metabolic Process Nucleocytoplasmic Transport Chromatin Remodeling Base-excision Repair Cellular Response To X-ray Nuclear Transport Aromatic Compound Catabolic Process Nucleosome Assembly Deoxyribonucleotide Catabolic Process DNA Strand Elongation Involved In DNA Replication Small Molecule Metabolic Process DNA Strand Elongation Biosynthetic Process Chromatin Assembly Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Transport Energy Derivation By Oxidation Of Organic Compounds	Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance RNA Biosynthetic Process Regulation Of Chromosome Organization Telomere Maintenance Negative Regulation Of Gene Expression Cell Division Negative Regulation Of DNA Metabolic Process RNA Metabolic Process Cell Separation After Cytokinesis Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Telomere Maintenance Negative Regulation Of Transcription, DNA-templated RNA-dependent DNA Replication Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Response To X-ray Cellular Macromolecule Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Mitotic Cell Cycle Phase Transition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Fibroblast Proliferation Biosynthetic Process Macromolecule Biosynthetic Process Response To Salt Stress Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Stem Cell Division Chromosome Organization Mitotic Cell Cycle Process Negative Regulation Of Clathrin-mediated Endocytosis Peptidyl-cysteine S-trans-nitrosylation Negative Regulation Of DNA Recombination At Telomere Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Gene Expression Mitotic Cell Cycle Neuron Apoptotic Process Cellular Response To Ionizing Radiation Negative Regulation Of Transcription From RNA Polymerase II Promoter 'de Novo' Posttranslational Protein Folding Metabolic Process
Tagcloud ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates	abpp acetylhydrolase acyl aided campaign carbamate carbamoylation cherry endeavored fluopol hits house hts hydrolase hydrolases medchem ml256 mudpit oxidatively phospholipids picked pla2g7 scaffold sid tunable
Tagcloud (Difference) ?		acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates	abpp acetylhydrolase acyl aided campaign carbamate carbamoylation cherry endeavored fluopol hits house hts hydrolase hydrolases medchem ml256 mudpit oxidatively phospholipids picked pla2g7 scaffold sid tunable
Tagcloud (Intersection) ?