POLE2 and AGFG1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		POLE2	AGFG1
Gene Name		polymerase (DNA directed), epsilon 2, accessory subunit	ArfGAP with FG repeats 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Epsilon DNA Polymerase Complex Intracellular Membrane-bounded Organelle	Nuclear Pore Cytoplasmic Membrane-bounded Vesicle Cell Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity	DNA Binding RNA Binding Protein Binding ARF GTPase Activator Activity Zinc Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA-dependent DNA Replication DNA Replication Initiation DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Error-prone Translesion Synthesis	Acrosome Assembly MRNA Export From Nucleus Multicellular Organismal Development Spermatid Nucleus Differentiation Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Intermediate Filament Organization
Pathways		Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Telomere C-strand synthesis initiation Gap-filling DNA repair synthesis and ligation in TC-NER Activation of the pre-replicative complex DNA Replication Pre-Initiation Repair synthesis for gap-filling by DNA polymerase in TC-NER Extension of Telomeres M/G1 Transition Activation of the pre-replicative complex S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER DNA replication initiation Global Genomic NER (GG-NER) Telomere Maintenance G1/S Transition Transcription-coupled NER (TC-NER) Mitotic G1-G1/S phases
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: AGFG1 C14orf1 EEF1A1 KAT5 MAPRE1 PKM POLE POLE4 REL SAP18 TBX15 TLE1 TRIM27	11 interactors: APC APP EPS15 EPS15L1 ITSN1 NYAP2 PKIA POLE2 RNF216 VAMP7 XPO1
Entrez ID		5427	3267
HPRD ID		16007	02918
Ensembl ID		ENSG00000100479	ENSG00000173744
Uniprot IDs		P56282	P52594
PDB IDs		2V6Z	2D9L 2OLM 2VX8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Negative Regulation Of Interleukin-2 Production Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Organelle Organization RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Interleukin-2 Secretion Positive Regulation Of Microtubule Plus-end Binding DNA Biosynthetic Process Histone Acetylation Chromosome Organization Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cytokine Production Regulation Of Cytokine Production Negative Regulation Of Calcium Ion Import Regulation Of Transcription, DNA-templated Base-excision Repair, Gap-filling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Localization To Microtubule Regulation Of RNA Metabolic Process Interferon-gamma Secretion Negative Regulation Of Cytokine Production Regulation Of Gene Expression, Epigenetic Chromatin Organization Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Gene Expression	Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Endocytosis Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Signaling Regulation Of Cell Cycle Phase Transition Neuron Projection Morphogenesis Regulation Of Intracellular Protein Transport Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Regulation Of Protein Localization Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Protein Targeting To Vacuolar Membrane Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Regulation Of Signal Transduction Neuron Development Apoptotic Process Post-Golgi Vesicle-mediated Transport Regulation Of Mitotic Cell Cycle Programmed Cell Death Regulation Of Intracellular Transport Regulation Of Cellular Localization Synaptic Growth At Neuromuscular Junction Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Cell Death Death Cell Morphogenesis Negative Regulation Of Signal Transduction Establishment Of Localization In Cell Neuron Differentiation Cell Surface Receptor Signaling Pathway Cell Projection Organization Ribosomal Small Subunit Export From Nucleus Positive Regulation Of Histamine Secretion By Mast Cell Regulation Of Histamine Secretion By Mast Cell Eosinophil Degranulation Collateral Sprouting In Absence Of Injury Triglyceride Transport Negative Regulation Of Signaling Axonogenesis Regulation Of Microtubule Cytoskeleton Organization Response To Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity
Tagcloud ?		algorithms applicable build disparate embedded ffpe fixed formalin format fresh frozen guide individualized mantle mcl minimum nearly optimized paraffin pathogenetic prediction prove qrt ran slc29a2 stepwise superior tnfrsf10b validated
Tagcloud (Difference) ?		algorithms applicable build disparate embedded ffpe fixed formalin format fresh frozen guide individualized mantle mcl minimum nearly optimized paraffin pathogenetic prediction prove qrt ran slc29a2 stepwise superior tnfrsf10b validated
Tagcloud (Intersection) ?