POLA1 and SMC1A

Number of citations of the paper that reports this interaction (PMID 16438930)
5

Data Source:
HPRD (in vivo)

		POLA1	SMC1A
Gene Name		polymerase (DNA directed), alpha 1, catalytic subunit	structural maintenance of chromosomes 1A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytoplasm Nuclear Matrix	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Cohesin Core Heterodimer Meiotic Cohesin Complex
	Molecular Function	Nucleotide Binding Nucleoside Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity DNA Primase Activity Protein Binding Protein Kinase Binding Metal Ion Binding Protein Heterodimerization Activity 4 Iron, 4 Sulfur Cluster Binding	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Poly(A) RNA Binding Protein Heterodimerization Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Proliferation Viral Process Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle MRNA Splicing, Via Spliceosome DNA Repair Mitotic Spindle Organization Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Mitotic Cell Cycle Checkpoint Meiotic Nuclear Division RNA Splicing Response To Radiation Gene Expression Stem Cell Maintenance Negative Regulation Of DNA Endoreduplication Signal Transduction In Response To DNA Damage Cell Division
Pathways		Activation of the pre-replicative complex Extension of Telomeres Activation of the pre-replicative complex Leading Strand Synthesis DNA strand elongation Polymerase switching DNA replication initiation Telomere Maintenance G1/S Transition G1/S-Specific Transcription Mitotic G1-G1/S phases E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Chromosome Maintenance Telomere C-strand synthesis initiation Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the lagging strand DNA Replication Pre-Initiation M/G1 Transition Telomere C-strand (Lagging Strand) Synthesis S Phase Cell Cycle, Mitotic Removal of the Flap Intermediate Inhibition of replication initiation of damaged DNA by RB1/E2F1	Establishment of Sister Chromatid Cohesion Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Mitotic Prometaphase Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Meiotic synapsis Cohesin Loading onto Chromatin mRNA Splicing - Major Pathway Mitotic Anaphase S Phase M Phase Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase
Drugs		Cladribine Clofarabine Fludarabine Nelarabine
Diseases
GWAS
Protein-Protein Interactions		17 interactors: CCNA2 CCNB1 CDC45 CDK1 CDK2 CDK2AP1 GINS4 HELB PARP1 POLA2 POLE RB1 RBMS1 SERPINA3 SMC1A TP53 XRCC5	16 interactors: ATM BLM BRCA1 MCM6 MCM7 MDC1 MET MSH2 MSH6 NDC80 NUMA1 POLA1 RAD21 RFC1 RPGR SMC3
Entrez ID		5422	8243
HPRD ID		02416	02077
Ensembl ID		ENSG00000101868	ENSG00000072501
Uniprot IDs		A6NMQ1 P09884	Q14683 Q68EN4
PDB IDs		1K0P 1K18 1N5G
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Replication Chromosome Organization Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle DNA-dependent DNA Replication Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Checkpoint Cellular Response To DNA Damage Stimulus Nucleobase-containing Compound Metabolic Process DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Negative Regulation Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process DNA Conformation Change Positive Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Mitotic Nuclear Division Regulation Of Cell Cycle Telomere Maintenance Cell Division Regulation Of Mitotic Cell Cycle Phase Transition Ras Protein Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Nuclear DNA Replication Mitotic DNA Integrity Checkpoint Biosynthetic Process DNA Strand Elongation Involved In DNA Replication Positive Regulation Of Mitotic Cell Cycle DNA Strand Elongation G2/M Transition Of Mitotic Cell Cycle DNA Replication Initiation Regulation Of DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition	Cell Cycle Process Cell Cycle Mitotic Cell Cycle DNA Recombination Mitotic Cell Cycle Process DNA Metabolic Process Cellular Response To DNA Damage Stimulus DNA Repair Double-strand Break Repair Organelle Organization Cellular Response To Stress Meiotic Cell Cycle DNA Strand Elongation Involved In DNA Replication Chromosome Organization DNA Strand Elongation DNA-dependent DNA Replication DNA Replication DNA Damage Checkpoint Meiotic Nuclear Division Telomere Maintenance Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle Checkpoint Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Mitotic DNA Damage Checkpoint Cellular Nitrogen Compound Metabolic Process Mitotic DNA Integrity Checkpoint Meiosis I DNA Replication Initiation Response To Stress Meiotic Mismatch Repair Nitrogen Compound Metabolic Process G2 DNA Damage Checkpoint Response To Ionizing Radiation Reciprocal Meiotic Recombination Mitotic Cell Cycle Checkpoint Positive Regulation Of Helicase Activity Intrinsic Apoptotic Signaling Pathway Response To Radiation Regulation Of DNA Recombination Negative Regulation Of Mitotic Cell Cycle Chromosome Segregation DNA Duplex Unwinding DNA Geometric Change
Tagcloud ?			12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc3 undetected
Tagcloud (Difference) ?			12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc3 undetected
Tagcloud (Intersection) ?